PMID- 38324025
OWN - NLM
STAT- MEDLINE
DCOM- 20240307
LR  - 20240404
IS  - 2731-7218 (Electronic)
IS  - 2731-720X (Linking)
VI  - 121
IP  - 3
DP  - 2024 Mar
TI  - [Allergen-specific immunotherapy : A brief overview in association with allergic 
      conjunctivitis].
PG  - 187-195
LID - 10.1007/s00347-024-01987-w [doi]
AB  - Allergen-specific immunotherapy (AIT) is the only causal and disease-modifying 
      treatment for immunoglobulin E (IgE)-mediated type I allergies. Regular exposure 
      to the causative allergen results in an immunomodulatory effect by which the 
      predominant T‑helper (Th) 2 lymphocyte response is shifted to a Th1 lymphocyte 
      response and more allergen-specific blocking immunoglobulins are produced. The 
      approval of substances for AIT is regulated by the Therapy Allergens Ordinance 
      (TAV). There are subcutaneous and/or sublingual AITs for the following 
      indications: allergic rhinitis, allergic conjunctivitis, allergic asthma and 
      insect venom allergy. In this article the indications for allergic conjunctivitis 
      are discussed in particular. Clinical symptoms and a relevant type 1 
      sensitization are the prerequisites for the indications for AIT. The assessment 
      of the indications and carrying out an AIT should only be carried out by 
      physicians who have been trained in allergology.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, 
      ein Teil von Springer Nature.
FAU - Lill, Diana
AU  - Lill D
AD  - Klinik und Poliklinik fur Dermatologie und Allergologie, LMU Klinikum, LMU 
      Munchen, Frauenlobstr. 9-11, 80337, Munchen, Deutschland. 
      diana.lill@med.uni-muenchen.de.
FAU - Bertlich, Mattis
AU  - Bertlich M
AD  - Klinik und Poliklinik fur Dermatologie und Allergologie, LMU Klinikum, LMU 
      Munchen, Frauenlobstr. 9-11, 80337, Munchen, Deutschland.
FAU - Oppel, Eva
AU  - Oppel E
AD  - Klinik und Poliklinik fur Dermatologie und Allergologie, LMU Klinikum, LMU 
      Munchen, Frauenlobstr. 9-11, 80337, Munchen, Deutschland.
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Allergenspezifische Immuntherapie : Ein kurzer Uberblick im Zusammenhang mit der 
      allergischen Konjunktivitis.
DEP - 20240207
PL  - Germany
TA  - Ophthalmologie
JT  - Die Ophthalmologie
JID - 9918402288106676
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - *Conjunctivitis, Allergic/therapy
MH  - Desensitization, Immunologic/methods
MH  - *Rhinitis, Allergic/therapy
MH  - Allergens/therapeutic use
MH  - Immunoglobulin E
OTO - NOTNLM
OT  - Allergic conjunctivitis
OT  - Immunoglobulins
OT  - Subcutaneous immunotherapy
OT  - Sublingual Immunotherapy
OT  - Therapy Allergens Ordinance
EDAT- 2024/02/07 12:44
MHDA- 2024/03/07 06:43
CRDT- 2024/02/07 11:04
PHST- 2024/01/09 00:00 [accepted]
PHST- 2024/03/07 06:43 [medline]
PHST- 2024/02/07 12:44 [pubmed]
PHST- 2024/02/07 11:04 [entrez]
AID - 10.1007/s00347-024-01987-w [pii]
AID - 10.1007/s00347-024-01987-w [doi]
PST - ppublish
SO  - Ophthalmologie. 2024 Mar;121(3):187-195. doi: 10.1007/s00347-024-01987-w. Epub 
      2024 Feb 7.