PMID- 38324637
OWN - NLM
STAT- MEDLINE
DCOM- 20240209
LR  - 20240209
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Linking)
VI  - 16
IP  - 733
DP  - 2024 Feb 7
TI  - Type 2-polarized memory B cells hold allergen-specific IgE memory.
PG  - eadi0944
LID - 10.1126/scitranslmed.adi0944 [doi]
AB  - Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases 
      such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to 
      circulating IgE by regenerating IgE-producing plasma cells upon allergen 
      encounter. Here, we report a population of type 2-polarized MBCs defined as 
      CD23(hi), IL-4Ralpha(hi), and CD32(low) at both the transcriptional and surface 
      protein levels. These MBC2s are enriched in IgG1- and IgG4-expressing cells while 
      constitutively expressing germline transcripts for IgE. Allergen-specific B cells 
      from patients with allergic rhinitis and food allergy were enriched in MBC2s. 
      Furthermore, MBC2s generated allergen-specific IgE during sublingual 
      immunotherapy, thereby identifying these cells as a major reservoir for IgE. The 
      identification of MBC2s provides insights into the maintenance of IgE memory, 
      which is detrimental in allergic diseases but could be beneficial in protection 
      against venoms and helminths.
FAU - Koenig, Joshua F E
AU  - Koenig JFE
AUID- ORCID: 0000-0002-8909-5039
AD  - Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, 
      McMaster University, Hamilton, ON L8S 4L8, Canada.
FAU - Knudsen, Niels Peter H
AU  - Knudsen NPH
AUID- ORCID: 0000-0003-1400-5657
AD  - ALK-Abello A/S, 2970 Horsholm, Denmark.
FAU - Phelps, Allyssa
AU  - Phelps A
AUID- ORCID: 0000-0002-5025-7459
AD  - Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, 
      McMaster University, Hamilton, ON L8S 4L8, Canada.
FAU - Bruton, Kelly
AU  - Bruton K
AUID- ORCID: 0000-0003-0817-6134
AD  - Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, 
      McMaster University, Hamilton, ON L8S 4L8, Canada.
FAU - Hoof, Ilka
AU  - Hoof I
AD  - ALK-Abello A/S, 2970 Horsholm, Denmark.
FAU - Lund, Gitte
AU  - Lund G
AUID- ORCID: 0000-0003-2221-7465
AD  - ALK-Abello A/S, 2970 Horsholm, Denmark.
FAU - Libera, Danielle Della
AU  - Libera DD
AUID- ORCID: 0009-0000-3633-051X
AD  - Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, 
      McMaster University, Hamilton, ON L8S 4L8, Canada.
FAU - Lund, Anders
AU  - Lund A
AUID- ORCID: 0000-0003-0051-8400
AD  - ALK-Abello A/S, 2970 Horsholm, Denmark.
FAU - Christensen, Lars Harder
AU  - Christensen LH
AUID- ORCID: 0000-0003-4230-7820
AD  - ALK-Abello A/S, 2970 Horsholm, Denmark.
FAU - Glass, David R
AU  - Glass DR
AUID- ORCID: 0000-0001-9924-167X
AD  - Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, 
      WA 98109, USA.
FAU - Walker, Tina D
AU  - Walker TD
AD  - Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, 
      McMaster University, Hamilton, ON L8S 4L8, Canada.
FAU - Fang, Allison
AU  - Fang A
AUID- ORCID: 0000-0002-5865-8695
AD  - Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, 
      McMaster University, Hamilton, ON L8S 4L8, Canada.
FAU - Waserman, Susan
AU  - Waserman S
AUID- ORCID: 0000-0002-2136-5995
AD  - Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, 
      McMaster University, Hamilton, ON L8S 4L8, Canada.
FAU - Jordana, Manel
AU  - Jordana M
AUID- ORCID: 0000-0002-5861-5994
AD  - Schroeder Allergy and Immunology Research Institute, Faculty of Health Sciences, 
      McMaster University, Hamilton, ON L8S 4L8, Canada.
FAU - Andersen, Peter S
AU  - Andersen PS
AUID- ORCID: 0000-0001-7615-8224
AD  - ALK-Abello A/S, 2970 Horsholm, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20240207
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Humans
MH  - *Rhinitis, Allergic, Seasonal/metabolism
MH  - Memory B Cells
MH  - Allergens
MH  - Immunoglobulin E
MH  - *Rhinitis, Allergic
MH  - Immunoglobulin G
MH  - *Food Hypersensitivity
EDAT- 2024/02/07 18:42
MHDA- 2024/02/09 06:42
CRDT- 2024/02/07 14:04
PHST- 2024/02/09 06:42 [medline]
PHST- 2024/02/07 18:42 [pubmed]
PHST- 2024/02/07 14:04 [entrez]
AID - 10.1126/scitranslmed.adi0944 [doi]
PST - ppublish
SO  - Sci Transl Med. 2024 Feb 7;16(733):eadi0944. doi: 10.1126/scitranslmed.adi0944. 
      Epub 2024 Feb 7.