PMID- 38324641
OWN - NLM
STAT- MEDLINE
DCOM- 20240209
LR  - 20240425
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Print)
IS  - 1946-6234 (Linking)
VI  - 16
IP  - 733
DP  - 2024 Feb 7
TI  - CD23(+)IgG1(+) memory B cells are poised to switch to pathogenic IgE production 
      in food allergy.
PG  - eadi0673
LID - 10.1126/scitranslmed.adi0673 [doi]
AB  - Food allergy is caused by allergen-specific immunoglobulin E (IgE) antibodies, 
      but little is known about the B cell memory of persistent IgE responses. Here, we 
      describe, in human pediatric peanut allergy, a population of CD23(+)IgG1(+) 
      memory B cells arising in type 2 immune responses that contain high-affinity 
      peanut-specific clones and generate IgE-producing cells upon activation. The 
      frequency of CD23(+)IgG1(+) memory B cells correlated with circulating 
      concentrations of IgE in children with peanut allergy. A corresponding population 
      of "type 2-marked" IgG1(+) memory B cells was identified in single-cell RNA 
      sequencing experiments. These cells differentially expressed interleukin-4 
      (IL-4)- and IL-13-regulated genes, such as FCER2/CD23(+), IL4R, and germline 
      IGHE, and carried highly mutated B cell receptors (BCRs). In children with high 
      concentrations of serum peanut-specific IgE, high-affinity B cells that bind the 
      main peanut allergen Ara h 2 mapped to the population of "type 2-marked" IgG1(+) 
      memory B cells and included clones with convergent BCRs across different 
      individuals. Our findings indicate that CD23(+)IgG1(+) memory B cells 
      transcribing germline IGHE are a unique memory population containing precursors 
      of high-affinity pathogenic IgE-producing cells that are likely to be involved in 
      the long-term persistence of peanut allergy.
FAU - Ota, Miyo
AU  - Ota M
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
AD  - Department of Immunology and Immunotherapy, Precision Immunology Institute 
      (PrIISM), ISMMS, New York, NY 10029, USA.
FAU - Hoehn, Kenneth B
AU  - Hoehn KB
AD  - Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
FAU - Fernandes-Braga, Weslley
AU  - Fernandes-Braga W
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
AD  - Department of Immunology and Immunotherapy, Precision Immunology Institute 
      (PrIISM), ISMMS, New York, NY 10029, USA.
FAU - Ota, Takayuki
AU  - Ota T
AD  - Department of Dermatology, Janssen Research & Development LLC, San Diego, CA 
      92121, USA.
FAU - Aranda, Carlos J
AU  - Aranda CJ
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
AD  - Department of Immunology and Immunotherapy, Precision Immunology Institute 
      (PrIISM), ISMMS, New York, NY 10029, USA.
FAU - Friedman, Sara
AU  - Friedman S
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
AD  - Department of Immunology and Immunotherapy, Precision Immunology Institute 
      (PrIISM), ISMMS, New York, NY 10029, USA.
FAU - Miranda-Waldetario, Mariana G C
AU  - Miranda-Waldetario MGC
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
AD  - Department of Immunology and Immunotherapy, Precision Immunology Institute 
      (PrIISM), ISMMS, New York, NY 10029, USA.
FAU - Redes, Jamie
AU  - Redes J
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
AD  - Department of Immunology and Immunotherapy, Precision Immunology Institute 
      (PrIISM), ISMMS, New York, NY 10029, USA.
AD  - Graduate School of Biomedical Sciences, ISMMS, New York, NY 10029, USA.
FAU - Suprun, Maria
AU  - Suprun M
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
FAU - Grishina, Galina
AU  - Grishina G
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
FAU - Sampson, Hugh A
AU  - Sampson HA
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
FAU - Malbari, Alefiyah
AU  - Malbari A
AD  - Kravis Children's Hospital, Department of Pediatrics, ISMMS, New York, NY 10029, 
      USA.
FAU - Kleinstein, Steven H
AU  - Kleinstein SH
AD  - Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
AD  - Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
AD  - Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT 
      06511, USA.
FAU - Sicherer, Scott H
AU  - Sicherer SH
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
FAU - Curotto de Lafaille, Maria A
AU  - Curotto de Lafaille MA
AD  - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy 
      Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, 
      USA.
AD  - Department of Immunology and Immunotherapy, Precision Immunology Institute 
      (PrIISM), ISMMS, New York, NY 10029, USA.
LA  - eng
GR  - R01 AI153708/AI/NIAID NIH HHS/United States
GR  - R01 AI104739/AI/NIAID NIH HHS/United States
GR  - R01 AI151707/AI/NIAID NIH HHS/United States
GR  - K99 AI159302/AI/NIAID NIH HHS/United States
GR  - T32 AI078892/AI/NIAID NIH HHS/United States
GR  - F31 AI172404/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20240207
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
RN  - 0 (Immunoglobulin G)
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
UOF - bioRxiv. 2023 Jan 25;:. PMID: 36747707
MH  - Humans
MH  - Child
MH  - *Peanut Hypersensitivity
MH  - Memory B Cells
MH  - Immunoglobulin G
MH  - *Food Hypersensitivity
MH  - Allergens
MH  - Immunoglobulin E
PMC - PMC11008013
MID - NIHMS1975647
EDAT- 2024/02/07 18:41
MHDA- 2024/02/09 06:42
PMCR- 2024/04/11
CRDT- 2024/02/07 14:04
PHST- 2024/02/09 06:42 [medline]
PHST- 2024/02/07 18:41 [pubmed]
PHST- 2024/02/07 14:04 [entrez]
PHST- 2024/04/11 00:00 [pmc-release]
AID - 10.1126/scitranslmed.adi0673 [doi]
PST - ppublish
SO  - Sci Transl Med. 2024 Feb 7;16(733):eadi0673. doi: 10.1126/scitranslmed.adi0673. 
      Epub 2024 Feb 7.