PMID- 38324863
OWN - NLM
STAT- MEDLINE
DCOM- 20240209
LR  - 20240210
IS  - 1678-4464 (Electronic)
IS  - 0102-311X (Print)
IS  - 0102-311X (Linking)
VI  - 40
IP  - 1
DP  - 2024
TI  - Dynapenia and sarcopenia: association with the diagnosis, duration and 
      complication of type 2 diabetes mellitus in ELSA-Brasil.
PG  - e00081223
LID - S0102-311X2024000105009 [pii]
LID - 10.1590/0102-311XEN081223 [doi]
LID - e00081223
AB  - Sarcopenia (the loss of muscle mass, strength and skeletal muscle function) 
      increases mortality and the risk of hospitalization in the older population. 
      Although it is known that older adults with type 2 diabetes mellitus (T2DM) have 
      a higher risk of dynapenia and sarcopenia, few studies have investigated these 
      conditions in middle-aged populations. The objective of this study was to 
      investigate whether T2DM, its duration, the presence of albuminuria, and glycemic 
      control are associated with sarcopenia and its components in adults. The 
      cross-sectional analysis was based on data from visit 2 of the Brazilian 
      Longitudinal Study of Adult Health (2012-2014). The 2018 European Working Group 
      on Sarcopenia in Older People criteria were used to define dynapenia, low 
      appendicular muscle mass (LAMM), and sarcopenia (absent/probable/confirmed). The 
      explanatory variables were: T2DM; duration of T2DM; T2DM according to the 
      presence of albuminuria; and glycemic control (HbA1C < 7%) among people with 
      T2DM. A total of 12,132 participants (mean age = 55.5, SD: 8.9 years) were 
      included. The odds ratio for LAMM was greater among those with T2DM, T2DM 
      duration from 5 to 10 years, and T2DM without albuminuria. Chances of dynapenia 
      were higher among those with T2DM, T2DM duration > 10 years, and T2DM with and 
      without albuminuria. The variables T2DM, T2DM >/= 10 years, and T2DM with 
      albuminuria increased the odds of probable sarcopenia, and T2DM duration from 5 
      to 10 years increased the odds of confirmed sarcopenia. The results support the 
      importance of frequently monitoring the musculoskeletal mass and strength of 
      individuals with T2DM to prevent sarcopenia and related outcomes.
FAU - Santos, Debora Noara Duarte Dos
AU  - Santos DNDD
AUID- ORCID: 0000-0003-3079-6831
AD  - Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Brasil.
FAU - Coelho, Carolina Gomes
AU  - Coelho CG
AUID- ORCID: 0000-0002-7294-3724
AD  - Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Brasil.
AD  - Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, 
      Brasil.
FAU - Diniz, Maria de Fatima Haueisen Sander
AU  - Diniz MFHS
AUID- ORCID: 0000-0001-9146-5003
AD  - Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Brasil.
FAU - Duncan, Bruce Bartholow
AU  - Duncan BB
AUID- ORCID: 0000-0002-7491-2630
AD  - Programa de Pos-graduacao em Epidemiologia, Universidade Federal do Rio Grande do 
      Sul, Porto Alegre, Brasil.
AD  - Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 
      Porto Alegre, Brasil.
FAU - Schmidt, Maria Ines
AU  - Schmidt MI
AUID- ORCID: 0000-0002-3837-0731
AD  - Programa de Pos-graduacao em Epidemiologia, Universidade Federal do Rio Grande do 
      Sul, Porto Alegre, Brasil.
AD  - Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 
      Porto Alegre, Brasil.
FAU - Bensenor, Isabela Judith Martins
AU  - Bensenor IJM
AUID- ORCID: 0000-0002-6723-5678
AD  - Universidade de Sao Paulo, Sao Paulo, Brasil.
FAU - Szlejf, Claudia
AU  - Szlejf C
AUID- ORCID: 0000-0002-0569-1184
AD  - Hospital Universitario, Universidade de Sao Paulo, Sao Paulo, Brasil.
FAU - Telles, Rosa Weiss
AU  - Telles RW
AUID- ORCID: 0000-0003-4027-2943
AD  - Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Brasil.
AD  - Hospital das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, 
      Brasil.
FAU - Barreto, Sandhi Maria
AU  - Barreto SM
AUID- ORCID: 0000-0001-7383-7811
AD  - Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 
      Brasil.
LA  - eng
PT  - Journal Article
DEP - 20240202
PL  - Brazil
TA  - Cad Saude Publica
JT  - Cadernos de saude publica
JID - 8901573
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - *Sarcopenia/complications
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Brazil/epidemiology
MH  - Cross-Sectional Studies
MH  - Longitudinal Studies
MH  - Albuminuria/complications
MH  - Hand Strength/physiology
PMC - PMC10841377
EDAT- 2024/02/07 18:41
MHDA- 2024/02/09 06:43
PMCR- 2024/02/02
CRDT- 2024/02/07 17:13
PHST- 2023/05/08 00:00 [received]
PHST- 2023/10/16 00:00 [accepted]
PHST- 2024/02/09 06:43 [medline]
PHST- 2024/02/07 18:41 [pubmed]
PHST- 2024/02/07 17:13 [entrez]
PHST- 2024/02/02 00:00 [pmc-release]
AID - S0102-311X2024000105009 [pii]
AID - 10.1590/0102-311XEN081223 [doi]
PST - epublish
SO  - Cad Saude Publica. 2024 Feb 2;40(1):e00081223. doi: 10.1590/0102-311XEN081223. 
      eCollection 2024.