PMID- 38326717
OWN - NLM
STAT- MEDLINE
DCOM- 20240209
LR  - 20240209
IS  - 2214-0190 (Electronic)
IS  - 0895-3988 (Linking)
VI  - 37
IP  - 1
DP  - 2024 Jan 20
TI  - Correlation between Combined Urinary Metal Exposure and Grip Strength under Three 
      Statistical Models: A Cross-sectional Study in Rural Guangxi.
PG  - 3-18
LID - 10.3967/bes2024.002 [doi]
AB  - OBJECTIVE: This study aimed to investigate the potential relationship between 
      urinary metals copper (Cu), arsenic (As), strontium (Sr), barium (Ba), iron (Fe), 
      lead (Pb) and manganese (Mn) and grip strength. METHODS: We used linear 
      regression models, quantile g-computation and Bayesian kernel machine regression 
      (BKMR) to assess the relationship between metals and grip strength. RESULTS: In 
      the multimetal linear regression, Cu (beta = -2.119), As (beta = -1.318), Sr (beta = 
      -2.480), Ba (beta = 0.781), Fe (beta = 1.130) and Mn (beta = -0.404) were significantly 
      correlated with grip strength ( P < 0.05). The results of the quantile 
      g-computation showed that the risk of occurrence of grip strength reduction was 
      -1.007 (95% confidence interval: -1.362, -0.652; P < 0.001) when each quartile of 
      the mixture of the seven metals was increased. Bayesian kernel function 
      regression model analysis showed that mixtures of the seven metals had a negative 
      overall effect on grip strength, with Cu, As and Sr being negatively associated 
      with grip strength levels. In the total population, potential interactions were 
      observed between As and Mn and between Cu and Mn ( P (interactions) of 0.003 and 
      0.018, respectively). CONCLUSION: In summary, this study suggests that combined 
      exposure to metal mixtures is negatively associated with grip strength. Cu, Sr 
      and As were negatively correlated with grip strength levels, and there were 
      potential interactions between As and Mn and between Cu and Mn.
CI  - Copyright (c) 2024 The Editorial Board of Biomedical and Environmental Sciences. 
      Published by China CDC. All rights reserved.
FAU - Liang, Yu Jian
AU  - Liang YJ
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Rong, Jia Hui
AU  - Rong JH
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Wang, Xue Xiu
AU  - Wang XX
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Cai, Jian Sheng
AU  - Cai JS
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China;Key Laboratory of 
      Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, 
      Guilin 541199, Guangxi, China.
FAU - Qin, Li Dong
AU  - Qin LD
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Liu, Qiu Mei
AU  - Liu QM
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Tang, Xu
AU  - Tang X
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Mo, Xiao Ting
AU  - Mo XT
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Wei, Yan Fei
AU  - Wei YF
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Lin, Yin Xia
AU  - Lin YX
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Huang, Shen Xiang
AU  - Huang SX
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Luo, Ting Yu
AU  - Luo TY
AD  - Department of Environmental Health and Occupational Medicine, School of Public 
      Health, Guilin Medical University, Guilin 541199, Guangxi, China.
FAU - Gou, Ruo Yu
AU  - Gou RY
AD  - Department of Environmental Health and Occupational Medicine, School of Public 
      Health, Guilin Medical University, Guilin 541199, Guangxi, China.
FAU - Cao, Jie Jing
AU  - Cao JJ
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Huang, Chu Wu
AU  - Huang CW
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Lu, Yu Fu
AU  - Lu YF
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Qin, Jian
AU  - Qin J
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China;Guangxi Colleges and 
      Universities Key Laboratory of Prevention and Control of Highly Prevalent 
      Diseases, Guangxi Medical University, Nanning 530021, Guangxi, China;Guangxi Key 
      Laboratory of Environment and Health Research, Guangxi Medical University, 
      Nanning 530021, Guangxi, China;Key Laboratory of Longevity and Aging-related 
      Diseases of Chinese Ministry of Education, Guangxi Medical University, Nanning 
      530021, Guangxi, China.
FAU - Zhang, Zhi Yong
AU  - Zhang ZY
AD  - Department of Environmental and Occupational Health, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China;Department of 
      Environmental Health and Occupational Medicine, School of Public Health, Guilin 
      Medical University, Guilin 541199, Guangxi, China;Guangxi Health Commission Key 
      Laboratory of Entire Lifecycle Health and Care, Guilin Medical University, Guilin 
      541199, Guangxi, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Biomed Environ Sci
JT  - Biomedical and environmental sciences : BES
JID - 8909524
RN  - 0 (Metals)
RN  - N712M78A8G (Arsenic)
RN  - YZS2RPE8LE (Strontium)
SB  - IM
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - China/epidemiology
MH  - *Metals/toxicity
MH  - *Arsenic
MH  - Strontium
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Handgrip strength
OT  - Quantile g-computation
OT  - Urinary metals
EDAT- 2024/02/08 00:42
MHDA- 2024/02/09 06:43
CRDT- 2024/02/07 23:33
PHST- 2023/07/16 00:00 [received]
PHST- 2023/10/12 00:00 [accepted]
PHST- 2024/02/09 06:43 [medline]
PHST- 2024/02/08 00:42 [pubmed]
PHST- 2024/02/07 23:33 [entrez]
AID - 10.3967/bes2024.002 [doi]
PST - ppublish
SO  - Biomed Environ Sci. 2024 Jan 20;37(1):3-18. doi: 10.3967/bes2024.002.