PMID- 38327845
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240211
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 18
DP  - 2024
TI  - The projection from dorsal medial prefrontal cortex to basolateral amygdala 
      promotes behaviors of negative emotion in rats.
PG  - 1331864
LID - 10.3389/fnins.2024.1331864 [doi]
LID - 1331864
AB  - Brain circuits between medial prefrontal cortex (mPFC) and amygdala have been 
      implicated in cortical control of emotion, especially anxiety. Studies in recent 
      years focus on differential roles of subregions of mPFC and amygdala, and 
      reciprocal pathways between mPFC and amygdala in regulation of emotional 
      behaviors. It has been shown that, while the projection from ventral mPFC to 
      basomedial amygdala has an anxiolytic effect, the reciprocal projections between 
      dorsal mPFC (dmPFC) and basolateral amygdala (BLA) are generally involved in an 
      anxiogenic effect in various conditions with increased anxiety. However, the 
      function of the projection from dmPFC to BLA in regulation of general emotional 
      behaviors under normal conditions remains unclear. In this study, we used 
      optogenetic analysis to identify how this dmPFC-BLA pathway regulates various 
      emotional behaviors in normal rats. We found that optogenetic stimulation of the 
      dmPFC-BLA pathway promoted a behavioral state of negative emotion, increasing 
      anxiety-like and depressive-like behaviors and producing aversive behavior of 
      place avoidance. Conversely, optogenetic inhibition of this pathway produced 
      opposite effects, reducing anxiety-like and depressive-like behaviors, and 
      inducing behaviors of place preference of reward. These findings suggest that 
      activity of the dmPFC-BLA pathway is sufficient to drive a negative emotion state 
      and the mPFC-amygdala circuit is tonically active in cortical regulation of 
      emotional behaviors.
CI  - Copyright (c) 2024 Cai, Ge and Pan.
FAU - Cai, Youqing
AU  - Cai Y
AD  - Department of Anesthesiology and Pain Medicine, The University of Texas MD 
      Anderson Cancer Center, Houston, TX, United States.
FAU - Ge, Jianlong
AU  - Ge J
AD  - Department of Anesthesiology and Pain Medicine, The University of Texas MD 
      Anderson Cancer Center, Houston, TX, United States.
FAU - Pan, Zhizhong Z
AU  - Pan ZZ
AD  - Department of Anesthesiology and Pain Medicine, The University of Texas MD 
      Anderson Cancer Center, Houston, TX, United States.
LA  - eng
GR  - RF1 NS113256/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20240124
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC10847313
OTO - NOTNLM
OT  - basal lateral amygdala
OT  - emotion
OT  - medial prefrontal cortex
OT  - optogenetics
OT  - pain
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/02/08 06:42
MHDA- 2024/02/08 06:43
PMCR- 2024/01/01
CRDT- 2024/02/08 04:11
PHST- 2023/11/01 00:00 [received]
PHST- 2024/01/10 00:00 [accepted]
PHST- 2024/02/08 06:43 [medline]
PHST- 2024/02/08 06:42 [pubmed]
PHST- 2024/02/08 04:11 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2024.1331864 [doi]
PST - epublish
SO  - Front Neurosci. 2024 Jan 24;18:1331864. doi: 10.3389/fnins.2024.1331864. 
      eCollection 2024.