PMID- 38327882
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
IS  - 2220-3206 (Print)
IS  - 2220-3206 (Electronic)
IS  - 2220-3206 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Jan 19
TI  - Assessing myocardial indices and inflammatory factors to determine anxiety and 
      depression severity in patients with chronic heart failure.
PG  - 53-62
LID - 10.5498/wjp.v14.i1.53 [doi]
AB  - BACKGROUND: Patients with chronic heart failure (CHF) have a progressive disease 
      that is associated with poor quality of life and high mortality. Many patients 
      experience anxiety and depression (A&D) symptoms, which can further accelerate 
      disease progression. We hypothesized that indicators of myocardial function and 
      inflammatory stress may reflect the severity of A&D symptoms in patients with 
      CHF. Changes in these biomarkers could potentially predict whether A&D symptoms 
      will deteriorate further in these individuals. AIM: To measure changes in cardiac 
      and inflammatory markers in patients with CHF to determine A&D severity and 
      predict outcomes. METHODS: We retrospectively analyzed 233 patients with CHF 
      treated at the Jingzhou Hospital, Yangtze University between 2018-2022 and 
      grouped them according to Self-Rating Anxiety Scale (SAS) and Self-Rating 
      Depression Scale (SDS) scores. We compared clinical data in the no-A&D, mild-A&D, 
      moderate-A&D, and severe-A&D groups, the SAS and SDS scores with the New York 
      Heart Association (NYHA) functional classification, and cardiac markers and 
      inflammatory factors between the no/mild-A&D and moderate/severe-A&D groups. 
      Regression analysis was performed on the markers with P < 0.05 to determine their 
      ability to predict A&D severity in patients and the area under the receiver 
      operating characteristic curve (AUROC) was used to evaluate their accuracy. 
      RESULTS: In the inter-group comparison, the following variables had an effect on 
      A&D severity in patients with CHF: NYHA class, left ventricular ejection fraction 
      (LVEF), left ventricular end-diastolic diameter, N-terminal pro-brain natriuretic 
      peptide (NT-proBNP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (P < 
      0.05). Other variables did not differ significantly between the A&D groups (P > 
      0.05). In addition, we found that higher NYHA classes were associated with higher 
      the SAS and SDS scores (P < 0.05). Regression analysis showed that LVEF, 
      NT-proBNP, and IL-6 were independent risk factors for A&D severity (P < 0.05). 
      Among them, NT-proBNP had the best predictive ability as a single indicator 
      (AUROC = 0.781). Furthermore, the combination of these three indicators exhibited 
      a good predictive effect toward discriminating the extent of A&D severity among 
      patients (AUROC = 0.875). CONCLUSION: Cardiac and inflammatory biomarkers, such 
      as LVEF, NT-proBNP, and IL-6, are correlated with A&D severity in patients with 
      CHF and have predictive value.
CI  - (c)The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Cardiology, Jingzhou Hospital, Yangtze University, Jingzhou 434020, 
      Hubei Province, China.
FAU - Wang, Qiang
AU  - Wang Q
AD  - Department of Cardiology, Jingzhou Hospital, Yangtze University, Jingzhou 434020, 
      Hubei Province, China.
FAU - Cui, Hong-Sheng
AU  - Cui HS
AD  - Department of Cardiology, Jingzhou Hospital, Yangtze University, Jingzhou 434020, 
      Hubei Province, China.
FAU - Luo, Yuan-Yuan
AU  - Luo YY
AD  - Department of Intensive Care Unit, The First Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China. 
      kellyyuan1983@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240119
PL  - United States
TA  - World J Psychiatry
JT  - World journal of psychiatry
JID - 101610480
PMC - PMC10845224
OTO - NOTNLM
OT  - Anxiety
OT  - Cardiac markers
OT  - Chronic heart failure
OT  - Depression
OT  - Inflammatory factors
OT  - Prediction
COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of 
      interest for this article.
EDAT- 2024/02/08 06:43
MHDA- 2024/02/08 06:44
PMCR- 2024/01/19
CRDT- 2024/02/08 04:12
PHST- 2023/11/06 00:00 [received]
PHST- 2023/11/25 00:00 [revised]
PHST- 2023/12/21 00:00 [accepted]
PHST- 2024/02/08 06:44 [medline]
PHST- 2024/02/08 06:43 [pubmed]
PHST- 2024/02/08 04:12 [entrez]
PHST- 2024/01/19 00:00 [pmc-release]
AID - 10.5498/wjp.v14.i1.53 [doi]
PST - epublish
SO  - World J Psychiatry. 2024 Jan 19;14(1):53-62. doi: 10.5498/wjp.v14.i1.53. 
      eCollection 2024 Jan 19.