PMID- 38328109
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240208
DP  - 2024 Jan 22
TI  - Individual variability in neural representations of mind-wandering.
LID - 2024.01.20.576471 [pii]
LID - 10.1101/2024.01.20.576471 [doi]
AB  - Mind-wandering is a frequent, daily mental activity, experienced in unique ways 
      in each person. Yet neuroimaging evidence relating mind-wandering to brain 
      activity, for example in the default mode network (DMN), has relied on 
      population-rather than individual-based inferences due to limited 
      within-individual sampling. Here, three densely-sampled individuals each reported 
      hundreds of mind-wandering episodes while undergoing multi-session functional 
      magnetic resonance imaging. We found reliable associations between mind-wandering 
      and DMN activation when estimating brain networks within individuals using 
      precision functional mapping. However, the timing of spontaneous DMN activity 
      relative to subjective reports, and the networks beyond DMN that were activated 
      and deactivated during mind-wandering, were distinct across individuals. 
      Connectome-based predictive modeling further revealed idiosyncratic, whole-brain 
      functional connectivity patterns that consistently predicted mind-wandering 
      within individuals but did not fully generalize across individuals. Predictive 
      models of mind-wandering and attention that were derived from larger-scale 
      neuroimaging datasets largely failed when applied to densely-sampled individuals, 
      further highlighting the need for personalized models. Our work offers novel 
      evidence for both conserved and variable neural representations of self-reported 
      mind-wandering in different individuals. The previously-unrecognized 
      inter-individual variations reported here underscore the broader scientific value 
      and potential clinical utility of idiographic approaches to brain-experience 
      associations.
FAU - Kucyi, Aaron
AU  - Kucyi A
AUID- ORCID: 0000-0001-6707-0028
FAU - Anderson, Nathan
AU  - Anderson N
FAU - Bounyarith, Tiara
AU  - Bounyarith T
FAU - Braun, David
AU  - Braun D
FAU - Shareef-Trudeau, Lotus
AU  - Shareef-Trudeau L
FAU - Treves, Isaac
AU  - Treves I
FAU - Braga, Rodrigo M
AU  - Braga RM
FAU - Hsieh, Po-Jang
AU  - Hsieh PJ
FAU - Hung, Shao-Min
AU  - Hung SM
LA  - eng
PT  - Preprint
DEP - 20240122
PL  - United States
TA  - bioRxiv
JT  - bioRxiv : the preprint server for biology
JID - 101680187
PMC - PMC10849545
EDAT- 2024/02/08 06:43
MHDA- 2024/02/08 06:44
PMCR- 2024/02/07
CRDT- 2024/02/08 04:15
PHST- 2024/02/08 06:44 [medline]
PHST- 2024/02/08 06:43 [pubmed]
PHST- 2024/02/08 04:15 [entrez]
PHST- 2024/02/07 00:00 [pmc-release]
AID - 2024.01.20.576471 [pii]
AID - 10.1101/2024.01.20.576471 [doi]
PST - epublish
SO  - bioRxiv [Preprint]. 2024 Jan 22:2024.01.20.576471. doi: 
      10.1101/2024.01.20.576471.