PMID- 38328480
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240228
IS  - 2472-1972 (Electronic)
IS  - 2472-1972 (Linking)
VI  - 8
IP  - 3
DP  - 2024 Jan 16
TI  - Abnormal Glucose Tolerance in Women Diagnosed With Gestational Diabetes 
      (WHO 2013) 10 Years After Index Pregnancy.
PG  - bvae013
LID - 10.1210/jendso/bvae013 [doi]
LID - bvae013
AB  - CONTEXT: It is not clear if the risk of abnormal glucose tolerance (AGT) is 
      attenuated in the long-term in women diagnosed with gestational diabetes (GDM) 
      using the World Health Organization (WHO) 2013 criteria and who have received 
      appropriate treatment during pregnancy. OBJECTIVE: We aimed to assess the 
      long-term prevalence of AGT and other cardiovascular disease (CVD) risk factors 
      in this cohort. METHODS: A retrospective cohort follow-up study was conducted of 
      37 and 107 women diagnosed with and without GDM respectively using the WHO 2013 
      criteria between June 2010 and December 2010. Women were invited to attend our 
      center, where they underwent a 75-g oral glucose tolerance test, blood and urine 
      collection, body measurements, and electrocardiography. Main outcome measure 
      included the development of AGT using the American Diabetes Association criteria. 
      RESULTS: Sixteen (43.2%) women with GDM compared to 5 (4.7%) women with normal 
      glucose tolerance (NGT) at index pregnancy had AGT (P < .001). In the GDM group, 
      10 (27.0%), 7 (18.9%), and 4 (10.8%) women had impaired fasting glucose (IFG), 
      impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM), 
      respectively. In the NGT group, 2 (1.9%), 3 (2.8%), and 1 (0.9%) woman had IFG, 
      IGT, and T2DM, respectively. Women with AGT also had an unfavorable metabolic 
      profile including obesity, hypertension, insulin resistance, and dyslipidemia. 
      CONCLUSION: Women treated for GDM (WHO 2013 criteria) remain at increased risk 
      for developing AGT and adverse CVD risk factors as early as a decade after 
      diagnosis. Continued efforts are needed to accurately follow this population to 
      address modifiable risk factors.
CI  - (c) The Author(s) 2024. Published by Oxford University Press on behalf of the 
      Endocrine Society.
FAU - Kgosidialwa, Oratile
AU  - Kgosidialwa O
AUID- ORCID: 0000-0002-4249-6302
AD  - College of Medicine, Nursing and Health Sciences, National University of Ireland 
      Galway, Galway, H91TK33, Ireland.
FAU - Newman, Christine
AU  - Newman C
AD  - College of Medicine, Nursing and Health Sciences, National University of Ireland 
      Galway, Galway, H91TK33, Ireland.
FAU - Carmody, Louise
AU  - Carmody L
AD  - College of Medicine, Nursing and Health Sciences, National University of Ireland 
      Galway, Galway, H91TK33, Ireland.
FAU - McGrath, Brian
AU  - McGrath B
AD  - College of Medicine, Nursing and Health Sciences, National University of Ireland 
      Galway, Galway, H91TK33, Ireland.
FAU - O'Shea, Paula M
AU  - O'Shea PM
AD  - College of Medicine, Nursing and Health Sciences, National University of Ireland 
      Galway, Galway, H91TK33, Ireland.
FAU - Dunne, Fidelma
AU  - Dunne F
AD  - College of Medicine, Nursing and Health Sciences, National University of Ireland 
      Galway, Galway, H91TK33, Ireland.
LA  - eng
PT  - Journal Article
DEP - 20240130
PL  - United States
TA  - J Endocr Soc
JT  - Journal of the Endocrine Society
JID - 101697997
PMC - PMC10849116
OTO - NOTNLM
OT  - abnormal glucose tolerance
OT  - cardiovascular risk factors
OT  - gestational diabetes
EDAT- 2024/02/08 06:42
MHDA- 2024/02/08 06:43
PMCR- 2024/01/30
CRDT- 2024/02/08 04:20
PHST- 2023/11/13 00:00 [received]
PHST- 2024/02/08 06:43 [medline]
PHST- 2024/02/08 06:42 [pubmed]
PHST- 2024/02/08 04:20 [entrez]
PHST- 2024/01/30 00:00 [pmc-release]
AID - bvae013 [pii]
AID - 10.1210/jendso/bvae013 [doi]
PST - epublish
SO  - J Endocr Soc. 2024 Jan 30;8(3):bvae013. doi: 10.1210/jendso/bvae013. eCollection 
      2024 Jan 16.