PMID- 38329710
OWN - NLM
STAT- MEDLINE
DCOM- 20240411
LR  - 20240425
IS  - 1568-5608 (Electronic)
IS  - 0925-4692 (Print)
IS  - 0925-4692 (Linking)
VI  - 32
IP  - 2
DP  - 2024 Apr
TI  - Evaluation of the biological efficiency of Terminalia chebula fruit extract 
      against neurochemical changes induced in brain of diabetic rats: an epigenetic 
      study.
PG  - 1439-1460
LID - 10.1007/s10787-024-01428-9 [doi]
AB  - Diabetes mellitus (DM) is a chronic and progressive metabolic disorder that can 
      stimulate neuroinflammation and increase oxidative stress in the brain. 
      Therefore, the present study was aimed to assess the efficacy of ethanolic 
      Terminalia chebula extract against the neurochemical and histopathological 
      changes induced in the brains of diabetic rats. The study clarified the reduction 
      in oxidative stress induced in the brains of diabetic rats by the significant 
      (P </= 0.05) increase in levels of the antioxidants with decreasing the 
      peroxidation products via ethanolic T. chebula extract at both doses (400 and 
      600 mg/kg). Moreover, T. chebula extract improved the brain integrity by lowering 
      levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), beta-amyloid (Abeta) 
      content, monocyte chemoattractant protein-1 (MCP-1) and acetylcholine esterase 
      (ACHE) significantly (P </= 0.05) in a dose dependent manner compared to brain of 
      diabetic rats. Severe nuclear pyknosis and degeneration were noticed in neurons 
      of the cerebral cortex, hippocampus and striatum in brains of diabetic rats. The 
      severity of these alterations decreased with T. chebula extract at a dose of 
      600 mg/kg compared to the other treated groups. The different electrophoretic 
      protein and isoenzyme assays revealed that the lowest similarity index (SI%) 
      values exist in the brains of diabetic rats compared to the control group. The 
      quantity of the most native proteins and isoenzyme types increased significantly 
      (P </= 0.05) in the brains of diabetic rats, and these electrophoretic variations 
      were completely diminished by T. chebula extract. The study concluded that T. 
      chebula extract ameliorated the biochemical, histopathological and 
      electrophoretic abnormalities induced in the brains of diabetic rats when 
      administered at a dose of 600 mg/kg.
CI  - (c) 2024. The Author(s).
FAU - El-Shamarka, Marwa E A
AU  - El-Shamarka MEA
AD  - Department of Narcotics, Ergogenic Aids and Poisons, Medical Research Institute, 
      National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), P.O. 12622, 
      Dokki, Giza, Egypt.
FAU - Aboulthana, Wael Mahmoud
AU  - Aboulthana WM
AUID- ORCID: 0000-0002-4848-0731
AD  - Biochemistry Department, Biotechnology Research Institute, National Research 
      Centre, 33 El Bohouth St. (Former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt. 
      wmkamel83@hotmail.com.
FAU - Omar, Nagwa Ibrahim
AU  - Omar NI
AD  - Biochemistry Department, Biotechnology Research Institute, National Research 
      Centre, 33 El Bohouth St. (Former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt.
FAU - Mahfouz, Marwa M
AU  - Mahfouz MM
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Menoufia 
      University, Shibin Al-Kawm, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20240208
PL  - Switzerland
TA  - Inflammopharmacology
JT  - Inflammopharmacology
JID - 9112626
RN  - 090OOA0454 (chebulae fruit)
RN  - 0 (Isoenzymes)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Diabetes Mellitus, Experimental/drug therapy
MH  - Isoenzymes
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - *Terminalia/chemistry
MH  - Brain
MH  - Epigenesis, Genetic
MH  - Fruit
PMC - PMC11006788
OTO - NOTNLM
OT  - Terminalia chebula
OT  - Diabetes mellitus
OT  - Electrophoretic isoenzymes
OT  - Neurodegeneration
OT  - Oxidative stress
COIS- The authors, who were responsible for carrying out the experiment, certify that 
      there were no declared conflict of interest.
EDAT- 2024/02/08 12:42
MHDA- 2024/04/11 06:42
PMCR- 2024/02/08
CRDT- 2024/02/08 11:18
PHST- 2023/08/24 00:00 [received]
PHST- 2024/01/02 00:00 [accepted]
PHST- 2024/04/11 06:42 [medline]
PHST- 2024/02/08 12:42 [pubmed]
PHST- 2024/02/08 11:18 [entrez]
PHST- 2024/02/08 00:00 [pmc-release]
AID - 10.1007/s10787-024-01428-9 [pii]
AID - 1428 [pii]
AID - 10.1007/s10787-024-01428-9 [doi]
PST - ppublish
SO  - Inflammopharmacology. 2024 Apr;32(2):1439-1460. doi: 10.1007/s10787-024-01428-9. 
      Epub 2024 Feb 8.