PMID- 38332001
OWN - NLM
STAT- MEDLINE
DCOM- 20240215
LR  - 20240215
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 14
IP  - 1
DP  - 2024 Feb 8
TI  - Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney 
      disease: a cross-sectional study.
PG  - 3211
LID - 10.1038/s41598-024-53567-2 [doi]
LID - 3211
AB  - Type 2 diabetic kidney disease (T2DKD) is a common microvascular complication of 
      type 2 diabetes mellitus (T2DM), and its incidence is significantly increasing. 
      Microinflammation plays an important role in the development of T2DKD. Based on 
      this, this study investigated the value of inflammatory markers including 
      neutrophil-lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hs-CRP), 
      monocyte chemoattractant protein-1 (MCP-1) in the prediction of T2DKD. This was a 
      cross-sectional survey study. A total of 90 patients with T2DM, who were 
      hospitalized in the nephrology and endocrinology departments of the First 
      Teaching Hospital of Tianjin University of Traditional Chinese Medicine from June 
      2021 to January 2022, were included and divided into three groups (A1, A2, A3) 
      according to the urinary albumin-to-creatinine ratio (UACR). Observe and compare 
      the basic information, clinical and laboratory data, and the inflammatory markers 
      NLR, hs-CRP, MCP-1. Results revealed that high levels of NLR (OR = 6.562, 95% CI 
      2.060-20.902, P = 0.001) and MCP-1 (OR = 1.060, 95% CI 1.026-1.095, P < 0.001) 
      were risk factors in the development of T2DKD. Receiver operating characteristic 
      curve analysis showed that the area under curve of NLR and MCP-1 in diagnosing 
      T2DKD were 0.760 (95% CI 0.6577-0.863, P < 0.001) and 0.862 (95% CI 0.7787-0.937, 
      P < 0.001). Therefore, the inflammatory markers NLR and MCP-1 are risk factors 
      affecting the development of T2DKD, which of clinical value may be used as novel 
      markers of T2DKD.
CI  - (c) 2024. The Author(s).
FAU - Fang, Yaxuan
AU  - Fang Y
AD  - Department of Nephrology, First Teaching Hospital of Tianjin University of 
      Traditional Chinese Medicine, Liqizhuang Street, Xiqing District, Tianjin, 
      300380, China.
AD  - Department of Nephrology, National Clinical Research Center for Chinese Medicine 
      Acupuncture and Moxibustion, Tianjin, China.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of Endocrinology, First Teaching Hospital of Tianjin University of 
      Traditional Chinese Medicine, Tianjin, China.
AD  - Department of Endocrinology, National Clinical Research Center for Chinese 
      Medicine Acupuncture and Moxibustion, Tianjin, China.
FAU - Pang, Bo
AU  - Pang B
AD  - Tianjin University of Traditional Chinese Medicine, Tianjin, China.
FAU - Zhou, Zijun
AU  - Zhou Z
AD  - Department of Nephrology, First Teaching Hospital of Tianjin University of 
      Traditional Chinese Medicine, Liqizhuang Street, Xiqing District, Tianjin, 
      300380, China.
AD  - Department of Nephrology, National Clinical Research Center for Chinese Medicine 
      Acupuncture and Moxibustion, Tianjin, China.
FAU - Xing, Yunze
AU  - Xing Y
AD  - Department of Nephrology, First Teaching Hospital of Tianjin University of 
      Traditional Chinese Medicine, Liqizhuang Street, Xiqing District, Tianjin, 
      300380, China.
AD  - Department of Nephrology, National Clinical Research Center for Chinese Medicine 
      Acupuncture and Moxibustion, Tianjin, China.
FAU - Pang, Pai
AU  - Pang P
AD  - Department of Endocrinology, First Teaching Hospital of Tianjin University of 
      Traditional Chinese Medicine, Tianjin, China.
AD  - Department of Endocrinology, National Clinical Research Center for Chinese 
      Medicine Acupuncture and Moxibustion, Tianjin, China.
FAU - Zheng, Dingyuan
AU  - Zheng D
AD  - Department of Nephrology, First Teaching Hospital of Tianjin University of 
      Traditional Chinese Medicine, Liqizhuang Street, Xiqing District, Tianjin, 
      300380, China.
AD  - Department of Nephrology, National Clinical Research Center for Chinese Medicine 
      Acupuncture and Moxibustion, Tianjin, China.
FAU - Zhang, Gang
AU  - Zhang G
AD  - The Community Health Service Center of Hangzhou Road Street in Tianjin Binhai New 
      Area, Tianjin, China.
FAU - Yang, Bo
AU  - Yang B
AD  - Department of Nephrology, First Teaching Hospital of Tianjin University of 
      Traditional Chinese Medicine, Liqizhuang Street, Xiqing District, Tianjin, 
      300380, China. yb8203@126.com.
AD  - Department of Nephrology, National Clinical Research Center for Chinese Medicine 
      Acupuncture and Moxibustion, Tianjin, China. yb8203@126.com.
LA  - eng
GR  - 20JCZXJC00060/Beijing-Tianjin-Hebei Basic Research Cooperative Project/
GR  - 2019BWKJ039/Grassroots Health Science and Technology Project of Tianjin Binhai 
      New Area Health Commission/
PT  - Journal Article
DEP - 20240208
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Chemokine CCL2)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CRP protein, human)
SB  - IM
MH  - Humans
MH  - C-Reactive Protein/analysis
MH  - Chemokine CCL2/urine
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Nephropathies/urine
MH  - Lymphocytes/chemistry
MH  - Neutrophils/chemistry
MH  - Retrospective Studies
MH  - ROC Curve
PMC - PMC10853504
COIS- The authors declare no competing interests.
EDAT- 2024/02/09 00:42
MHDA- 2024/02/10 10:47
PMCR- 2024/02/08
CRDT- 2024/02/08 23:49
PHST- 2023/09/14 00:00 [received]
PHST- 2024/02/02 00:00 [accepted]
PHST- 2024/02/10 10:47 [medline]
PHST- 2024/02/09 00:42 [pubmed]
PHST- 2024/02/08 23:49 [entrez]
PHST- 2024/02/08 00:00 [pmc-release]
AID - 10.1038/s41598-024-53567-2 [pii]
AID - 53567 [pii]
AID - 10.1038/s41598-024-53567-2 [doi]
PST - epublish
SO  - Sci Rep. 2024 Feb 8;14(1):3211. doi: 10.1038/s41598-024-53567-2.