PMID- 38332862
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 18
DP  - 2024
TI  - Altered cortical thickness-based structural covariance networks in type 2 
      diabetes mellitus.
PG  - 1327061
LID - 10.3389/fnins.2024.1327061 [doi]
LID - 1327061
AB  - Cognitive impairment is a common complication of type 2 diabetes mellitus (T2DM), 
      and early cognitive dysfunction may be associated with abnormal changes in the 
      cerebral cortex. This retrospective study aimed to investigate the cortical 
      thickness-based structural topological network changes in T2DM patients without 
      mild cognitive impairment (MCI). Fifty-six T2DM patients and 59 healthy controls 
      underwent neuropsychological assessments and sagittal 3-dimensional T1-weighted 
      structural magnetic resonance imaging. Then, we combined cortical thickness-based 
      assessments with graph theoretical analysis to explore the abnormalities in 
      structural covariance networks in T2DM patients. Correlation analyses were 
      performed to investigate the relationship between the altered topological 
      parameters and cognitive/clinical variables. T2DM patients exhibited 
      significantly lower clustering coefficient (C) and local efficiency (Elocal) 
      values and showed nodal property disorders in the occipital cortical, inferior 
      temporal, and inferior frontal regions, the precuneus, and the precentral and 
      insular gyri. Moreover, the structural topological network changes in multiple 
      nodes were correlated with the findings of neuropsychological tests in T2DM 
      patients. Thus, while T2DM patients without MCI showed a relatively normal global 
      network, the local topological organization of the structural network was 
      disordered. Moreover, the impaired ventral visual pathway may be involved in the 
      neural mechanism of visual cognitive impairment in T2DM patients. This study 
      enriched the characteristics of gray matter structure changes in early cognitive 
      dysfunction in T2DM patients.
CI  - Copyright (c) 2024 Huang, Zhang, Cheng, Yang, Liu, Ai, Tang, Zhang, Lei and Zhang.
FAU - Huang, Yang
AU  - Huang Y
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Cheng, Miao
AU  - Cheng M
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Yang, Zhen
AU  - Yang Z
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Liu, Wanting
AU  - Liu W
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Ai, Kai
AU  - Ai K
AD  - Department of Clinical and Technical Support, Philips Healthcare, Xi'an, China.
FAU - Tang, Min
AU  - Tang M
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Zhang, Xiaoling
AU  - Zhang X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Lei, Xiaoyan
AU  - Lei X
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
FAU - Zhang, Dongsheng
AU  - Zhang D
AD  - Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.
LA  - eng
PT  - Journal Article
DEP - 20240124
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC10851426
OTO - NOTNLM
OT  - cortical thickness
OT  - neuroimaging
OT  - structural network
OT  - topological properties
OT  - type 2 diabetes mellitus
COIS- KA was employed by company Philips Healthcare. The remaining authors declare that 
      the research was conducted in the absence of any commercial or financial 
      relationships that could be construed as a potential conflict of interest.
EDAT- 2024/02/09 06:42
MHDA- 2024/02/09 06:43
PMCR- 2024/01/01
CRDT- 2024/02/09 03:45
PHST- 2023/10/24 00:00 [received]
PHST- 2024/01/11 00:00 [accepted]
PHST- 2024/02/09 06:43 [medline]
PHST- 2024/02/09 06:42 [pubmed]
PHST- 2024/02/09 03:45 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2024.1327061 [doi]
PST - epublish
SO  - Front Neurosci. 2024 Jan 24;18:1327061. doi: 10.3389/fnins.2024.1327061. 
      eCollection 2024.