PMID- 38333950
OWN - NLM
STAT- MEDLINE
DCOM- 20240222
LR  - 20240222
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 72
IP  - 7
DP  - 2024 Feb 21
TI  - Effects of Oat beta-Glucan and Inulin on Alleviation of Nonalcoholic Steatohepatitis 
      Aggravated by Circadian Disruption in C57BL/6J Mice.
PG  - 3520-3535
LID - 10.1021/acs.jafc.3c08028 [doi]
AB  - This was the first study that examined the effects of oat beta-glucan and inulin on 
      diet-induced nonalcoholic steatohepatitis (NASH) in circadian-disrupted (CD)-male 
      C57BL/6J mice. CD intensified NASH, significantly increasing alanine 
      aminotransferase and upregulating hepatic tumor necrosis factor alpha (TNFalpha) and 
      transforming growth factor beta 1 (TGFbeta1). However, these observations were 
      significantly alleviated by oat beta-glucan and inulin treatments. Compared to CD 
      NASH mice, oat beta-glucan significantly decreased the liver index, aspartate 
      aminotransferase (AST), and insulin. In prebiotic-treated and CD NASH mice, 
      significant negative correlations were found between enrichment of Muribaculaceae 
      bacterium Isolate-036 (Harlan), Muribaculaceae bacterium Isolate-001 (NCI), and 
      Bacteroides ovatus after oat beta-glucan supplementation with TNFalpha and TGFbeta1 levels; 
      and enrichment of Muribaculaceae bacterium Isolate-110 (HZI) after inulin 
      supplementation with AST level. In conclusion, oat beta-glucan and inulin exhibited 
      similar antiliver injury, anti-inflammatory, and antifibrotic activities but had 
      no effect on cecal short-chain fatty acids and gut microbiota diversity in CD 
      NASH mice.
FAU - Kei, Nelson
AU  - Kei N
AUID- ORCID: 0009-0005-8247-6196
AD  - Food and Nutritional Sciences Program, School of Life Sciences, The Chinese 
      University of Hong Kong, New Territories, Hong Kong SAR, China.
FAU - Cheung, Kam Kuen
AU  - Cheung KK
AD  - Food and Nutritional Sciences Program, School of Life Sciences, The Chinese 
      University of Hong Kong, New Territories, Hong Kong SAR, China.
AD  - Food Research Centre, The Chinese University of Hong Kong, New Territories, Hong 
      Kong SAR , China.
FAU - Ma, Ka Lee
AU  - Ma KL
AUID- ORCID: 0000-0002-4533-5547
AD  - Food and Nutritional Sciences Program, School of Life Sciences, The Chinese 
      University of Hong Kong, New Territories, Hong Kong SAR, China.
FAU - Yau, Tsz Kwan
AU  - Yau TK
AD  - Cell and Molecular Biology Program, School of Life Sciences, The Chinese 
      University of Hong Kong, New Territories, Hong Kong SAR, China.
FAU - Lauw, Susana
AU  - Lauw S
AUID- ORCID: 0009-0008-7751-6159
AD  - Food and Nutritional Sciences Program, School of Life Sciences, The Chinese 
      University of Hong Kong, New Territories, Hong Kong SAR, China.
AD  - Food Research Centre, The Chinese University of Hong Kong, New Territories, Hong 
      Kong SAR , China.
FAU - Wong, Vincent Wai Sun
AU  - Wong VWS
AD  - Department of Medicine and Therapeutics, The Chinese University of Hong Kong, New 
      Territories, Hong Kong SAR, China.
FAU - You, Lijun
AU  - You L
AUID- ORCID: 0000-0001-7873-3894
AD  - School of Food Science and Engineering, South China University of Technology, 
      Guangzhou 510640, China.
FAU - Cheung, Peter Chi Keung
AU  - Cheung PCK
AUID- ORCID: 0000-0001-5155-7173
AD  - Food and Nutritional Sciences Program, School of Life Sciences, The Chinese 
      University of Hong Kong, New Territories, Hong Kong SAR, China.
AD  - Food Research Centre, The Chinese University of Hong Kong, New Territories, Hong 
      Kong SAR , China.
LA  - eng
PT  - Journal Article
DEP - 20240209
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 9005-80-5 (Inulin)
RN  - 55965-23-6 (beta-glucan, (1-3)(1-4)-)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (beta-Glucans)
SB  - IM
MH  - Male
MH  - Mice
MH  - Animals
MH  - *Non-alcoholic Fatty Liver Disease/drug therapy/etiology/metabolism
MH  - Inulin/metabolism
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
MH  - Mice, Inbred C57BL
MH  - Liver/metabolism
MH  - *beta-Glucans
OTO - NOTNLM
OT  - circadian disruption
OT  - inulin
OT  - nonalcoholic steatohepatitis (NASH)
OT  - beta-glucan
EDAT- 2024/02/09 06:42
MHDA- 2024/02/22 06:42
CRDT- 2024/02/09 04:23
PHST- 2024/02/22 06:42 [medline]
PHST- 2024/02/09 06:42 [pubmed]
PHST- 2024/02/09 04:23 [entrez]
AID - 10.1021/acs.jafc.3c08028 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2024 Feb 21;72(7):3520-3535. doi: 10.1021/acs.jafc.3c08028. 
      Epub 2024 Feb 9.