PMID- 38334159
OWN - NLM
STAT- Publisher
LR  - 20240209
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
DP  - 2024 Feb 9
TI  - Validated Symptom Outcomes Following Septal Perforation Repair: Application of 
      the NOSE-Perf Scale.
LID - 10.1002/lary.31329 [doi]
AB  - OBJECTIVE: The Nasal Obstruction Symptom Evaluation (NOSE)-Perf scale was 
      developed and validated to measure symptoms associated with nasal septal 
      perforations. This study reports the application of the NOSE-Perf scale to 
      evaluate symptom change following septal perforation repair. METHODS: Patients 
      with NOSE-Perf evaluations >/=6 months following attempted perforation closure from 
      July 2018 to December 2021 utilizing bilateral nasal mucosal flaps with an 
      interposition graft were eligible for study inclusion. Change in NOSE-Perf scores 
      were noted. Patient demographics, perforation size, and concurrent functional 
      procedures were analyzed for impact on symptom outcomes. RESULTS: One-hundred and 
      seventeen patients met the study criteria. Seventy-nine (67.5%) of the patients 
      were female and the mean (range) age at surgery was 47.3 (14-78) years. Repair 
      failure was noted in 7 (6.0%) patients. Mean (SD) preoperative NOSE-Perf score 
      was 25.3 (95% CI, 23.5-27.1) and postoperative score was 7.9 (95% CI, 6.5-9.3). 
      Minimal clinically important difference (MCID) was estimated and greater than 91% 
      of patients had improvement above this threshold. Patient age, perforation size, 
      or concurrent functional procedures did not impact outcomes. Postoperative scores 
      at short (2-4 months), intermediate (5-8 months), and long-term (>/=9 months) time 
      periods showed significant improvement (all p < 0.001) compared to preoperative 
      NOSE-Perf scores. CONCLUSION: Significant reduction in nasal symptoms as measured 
      by the NOSE-Perf scale is noted following bilateral mucosal flap repair. Although 
      the nose does not completely normalize following repair, clinically important 
      improvement was noted in at least 91% of patients. The NOSE-Perf scale is 
      positioned to play a role in the standardization of septal perforation evaluation 
      and outcomes assessment. LEVEL OF EVIDENCE: IV Laryngoscope, 2024.
CI  - (c) 2024 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Taylor, Cullen M
AU  - Taylor CM
AUID- ORCID: 0000-0002-4088-5195
AD  - Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic, Phoenix, 
      Arizona, U.S.A.
FAU - Bansberg, Stephen F
AU  - Bansberg SF
AD  - Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic, Phoenix, 
      Arizona, U.S.A.
FAU - Marino, Michael J
AU  - Marino MJ
AUID- ORCID: 0000-0002-8672-0310
AD  - Department of Otolaryngology - Head and Neck Surgery, Mayo Clinic, Phoenix, 
      Arizona, U.S.A.
LA  - eng
PT  - Journal Article
DEP - 20240209
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
OTO - NOTNLM
OT  - nasal septal perforation
OT  - outcomes
OT  - quality of life
EDAT- 2024/02/09 12:43
MHDA- 2024/02/09 12:43
CRDT- 2024/02/09 07:50
PHST- 2024/01/03 00:00 [revised]
PHST- 2023/10/26 00:00 [received]
PHST- 2024/01/22 00:00 [accepted]
PHST- 2024/02/09 12:43 [medline]
PHST- 2024/02/09 12:43 [pubmed]
PHST- 2024/02/09 07:50 [entrez]
AID - 10.1002/lary.31329 [doi]
PST - aheadofprint
SO  - Laryngoscope. 2024 Feb 9. doi: 10.1002/lary.31329.