PMID- 38335725
OWN - NLM
STAT- MEDLINE
DCOM- 20240403
LR  - 20240403
IS  - 1943-5681 (Electronic)
IS  - 0002-9645 (Linking)
VI  - 85
IP  - 4
DP  - 2024 Apr 1
TI  - The Edwards Acumen IQ system using peripheral arterial catheter-based waveforms 
      to estimate cardiac output is not accurate as compared to thermodilution in dogs.
LID - ajvr.23.11.0249 [pii]
LID - 10.2460/ajvr.23.11.0249 [doi]
AB  - OBJECTIVE: To assess the agreement between cardiac output (CO) estimated via 
      evaluation of the arterial pressure waveform by a novel monitoring system 
      (Edwards Acumen IQ sensor and HemoSphere Advanced Monitor Platform [HS-IQ]; 
      Edwards LifeSciences) and measured by thermodilution (TD) in anesthetized, 
      normovolemic, and hypovolemic dogs. To assess the agreement between the HS-IQ CO 
      measurements in the radial artery and dorsal metatarsal artery. ANIMALS: 8 
      purpose-bred Beagles. METHODS: Dogs were placed under general anesthesia. CO was 
      measured via TD and via the HS-IQ at radial and dorsal metatarsal arterial 
      catheters. CO measurements were obtained at 4 time points including normovolemic 
      and multiple hypovolemic states. Paired measurements of CO were evaluated via the 
      method of Bland and Altman with acceptable limits of agreement (LOA) defined as < 
      30%. RESULTS: A total of 24 (dorsal metatarsal) and 21 (radial) paired 
      measurements were collected in 8 dogs. The overall bias (CI) for comparison of TD 
      to radial arterial HS-IQ CO measurements was -0.09 L/min. LOA and proportional 
      LOA were -2.66 to 2.49 L/min and -140.72% to 104.94%. The overall bias (CI) for 
      comparison of TD to dorsal metatarsal arterial HS-IQ CO measurements was -0.26 
      L/min. LOA and proportional LOA were -2.76 to 2.24 L/min and -135.96% to 93.25%. 
      The overall proportional error for radial arterial was -17.9% and for dorsal 
      metatarsal was -21.4%. CLINICAL RELEVANCE: CO measurements with the HS-IQ were 
      easy to obtain but did not produce results within a clinically acceptable range 
      for either measurement site, with a very wide LOA. The CO estimations from the 
      HS-IQ are not appropriate for clinical use at this time.
FAU - Zersen, Kristin M
AU  - Zersen KM
AUID- ORCID: 0000-0003-0327-8537
FAU - Griffenhagen, Gregg M
AU  - Griffenhagen GM
AUID- ORCID: 0000-0003-3522-5587
FAU - Monnet, Eric L
AU  - Monnet EL
AUID- ORCID: 0000-0002-0058-2210
LA  - eng
PT  - Journal Article
DEP - 20240213
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
SB  - IM
MH  - Dogs
MH  - Animals
MH  - *Thermodilution/veterinary/methods
MH  - Hypovolemia/veterinary
MH  - Monitoring, Intraoperative/methods/veterinary
MH  - Cardiac Output
MH  - Arteries
MH  - Catheters, Indwelling
MH  - Reproducibility of Results
MH  - *Dog Diseases/diagnosis
OTO - NOTNLM
OT  - arterial catheter
OT  - cardiac output
OT  - hypovolemia
OT  - normovolemia
OT  - thermodilution
EDAT- 2024/02/10 13:18
MHDA- 2024/04/03 06:44
CRDT- 2024/02/09 18:06
PHST- 2023/11/07 00:00 [received]
PHST- 2024/01/24 00:00 [accepted]
PHST- 2024/04/03 06:44 [medline]
PHST- 2024/02/10 13:18 [pubmed]
PHST- 2024/02/09 18:06 [entrez]
AID - ajvr.23.11.0249 [pii]
AID - 10.2460/ajvr.23.11.0249 [doi]
PST - epublish
SO  - Am J Vet Res. 2024 Feb 13;85(4):ajvr.23.11.0249. doi: 10.2460/ajvr.23.11.0249. 
      Print 2024 Apr 1.