PMID- 38337336
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240212
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 13
IP  - 3
DP  - 2024 Jan 23
TI  - Effectiveness and Safety of the Intermittently Scanned Continuous Glucose 
      Monitoring System FreeStyle Libre 2 in Patients with Type 2 Diabetes Treated with 
      Basal Insulin or Oral Antidiabetic Drugs: An Observational, Retrospective 
      Real-World Study.
LID - 10.3390/jcm13030642 [doi]
LID - 642
AB  - Intermittently Scanned Continuous Glucose Monitoring (isCGM) devices are 
      increasingly being used in patients with type 2 diabetes mellitus (T2DM) on 
      insulin therapy for their benefits regarding disease management. Evidence of 
      isCGM use in patients with T2DM on basal or non-insulin therapy is lacking. This 
      study aimed at assessing the efficacy and safety of isCGM in this population. 
      This was an observational, retrospective, real-world study enrolling patients 
      with T2DM who were starting the use of isCGM. Data from medical records (i.e., 
      demographics, clinical characteristics, laboratory assessments, and isCGM 
      metrics) were collected over three time periods (baseline, 3 and 6 months). The 
      endpoints were glycated haemoglobin (HbA1c) changes and changes in isCGM metrics 
      as defined by the International Consensus from baseline to 3 months and 6 months. 
      Overall, 132 patients were included (69.5% male; mean age 68.2 +/- 11.0 years; mean 
      disease duration 19.0 +/- 9.4 years; 79.7% on basal insulin +/-non-insulin therapy; 
      mean baseline HbA1c 8.1% +/- 1.3%). The estimated mean change in HbA1c was 
      statistically significant at three (-0.4 +/- 1.0%; p = 0.003) and six months (-0.6 
      +/- 1.3%; p < 0.0001). In conclusion, isCGM proved to be effective and safe in 
      improving glycaemic control in patients with T2DM on basal insulin or non-insulin 
      therapy.
FAU - Conti, Matteo
AU  - Conti M
AD  - Diabetes Unit, Niguarda Ca Granda Hospital, 20162 Milan, Italy.
AD  - Department of Medicine and Surgery, University of Milan-Bicocca, 20126 Milan, 
      Italy.
FAU - Massari, Giulia
AU  - Massari G
AD  - Diabetes Unit, Spedali Civili di Brescia, 25123 Brescia, Italy.
FAU - Meneghini, Elena
AU  - Meneghini E
AD  - Diabetes Unit, Niguarda Ca Granda Hospital, 20162 Milan, Italy.
FAU - Pasquino, Bernadetta
AU  - Pasquino B
AD  - Diabetes Unit, Spedali Civili di Brescia, 25123 Brescia, Italy.
FAU - Agosti, Barbara
AU  - Agosti B
AD  - Diabetes Unit, Spedali Civili di Brescia, 25123 Brescia, Italy.
FAU - Chinotti, Federica
AU  - Chinotti F
AD  - University of Milan, 20122 Milan, Italy.
FAU - Pintaudi, Basilio
AU  - Pintaudi B
AD  - Diabetes Unit, Niguarda Ca Granda Hospital, 20162 Milan, Italy.
FAU - Girelli, Angela
AU  - Girelli A
AUID- ORCID: 0009-0008-9411-1858
AD  - Diabetes Unit, Spedali Civili di Brescia, 25123 Brescia, Italy.
FAU - Bertuzzi, Federico
AU  - Bertuzzi F
AD  - Diabetes Unit, Niguarda Ca Granda Hospital, 20162 Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20240123
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10856078
OTO - NOTNLM
OT  - basal insulin
OT  - flash glucose monitoring
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2024/02/10 10:53
MHDA- 2024/02/10 10:54
PMCR- 2024/01/23
CRDT- 2024/02/10 01:02
PHST- 2024/01/02 00:00 [received]
PHST- 2024/01/16 00:00 [revised]
PHST- 2024/01/19 00:00 [accepted]
PHST- 2024/02/10 10:54 [medline]
PHST- 2024/02/10 10:53 [pubmed]
PHST- 2024/02/10 01:02 [entrez]
PHST- 2024/01/23 00:00 [pmc-release]
AID - jcm13030642 [pii]
AID - jcm-13-00642 [pii]
AID - 10.3390/jcm13030642 [doi]
PST - epublish
SO  - J Clin Med. 2024 Jan 23;13(3):642. doi: 10.3390/jcm13030642.