PMID- 38337412
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240212
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 13
IP  - 3
DP  - 2024 Jan 26
TI  - Risk Factors for Corneal Endothelial Decompensation after Penetrating 
      Keratoplasty: A Population-Based Cohort Study.
LID - 10.3390/jcm13030718 [doi]
LID - 718
AB  - (1) Background: Endothelial decompensation is a common complication after 
      penetrating keratopathy (PK), while the risk factors for endothelial 
      decompensation after PK have not been fully elucidated. Consequently, we aim to 
      investigate the possible risk factors for endothelial decompensation after PK. 
      (2) Methods: This retrospective study was conducted using the National Health 
      Insurance Research Database (NHIRD) of Taiwan. The main outcome was the 
      development of endothelial decompensation after PK surgery. The effects of 
      potential risk factors were compared between the patients with endothelial 
      decompensation and the patients without endothelial decompensation via Cox 
      proportional hazard regression, which produced the adjusted hazard ratio (aHR) 
      and a 95% confidence interval (CI). (3) Results: Overall, 54 patients developed 
      endothelial decompensation after PK surgery, with a ratio of 16.12 percent. The 
      pre-existing type 2 diabetes mellitus (T2DM) (aHR: 1.924, 95% CI: 1.257-2.533, p 
      = 0.0095) and history of cataract surgery (aHR: 1.687, 95% CI: 1.328-2.440, p = 
      0.0026) were correlated with the development of endothelial decompensation. In 
      the subgroup analysis, the correlation between a history of cataract surgery and 
      post-PK endothelial decompensation was more prominent in patients older than 60 
      years compared to their younger counterparts (p = 0.0038). (4) Conclusions: 
      Pre-existing T2DM and a history of cataract surgery are associated with a higher 
      incidence of post-PK endothelial decompensation.
FAU - Chen, Hung-Chi
AU  - Chen HC
AUID- ORCID: 0000-0002-1117-7878
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, 
      Taiwan.
AD  - Department of Medicine, Chang Gung University College of Medicine, Taoyuan 333, 
      Taiwan.
AD  - Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, 
      Taiwan.
FAU - Lee, Chia-Yi
AU  - Lee CY
AUID- ORCID: 0000-0002-5719-0488
AD  - Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
AD  - Nobel Eye Institute, Taipei 115, Taiwan.
AD  - Department of Ophthalmology, Jen-Ai Hospital Dali Branch, Taichung 412, Taiwan.
FAU - Chang, Yu-Ling
AU  - Chang YL
AD  - Department of Medical Education, Cathay General Hospital, Taipei 106, Taiwan.
FAU - Huang, Jing-Yang
AU  - Huang JY
AUID- ORCID: 0000-0002-0794-9388
AD  - Department of Medical Research, Chung Shan Medical University Hospital, Taichung 
      402, Taiwan.
FAU - Yang, Shun-Fa
AU  - Yang SF
AUID- ORCID: 0000-0002-0365-7927
AD  - Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
AD  - Department of Medical Research, Chung Shan Medical University Hospital, Taichung 
      402, Taiwan.
FAU - Chang, Chao-Kai
AU  - Chang CK
AD  - Nobel Eye Institute, Taipei 115, Taiwan.
AD  - Department of Optometry, Da-Yeh University, Chunghua 515, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20240126
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10856645
OTO - NOTNLM
OT  - cataract surgery
OT  - endothelial decompensation
OT  - epidemiology
OT  - penetrating keratoplasty
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflicts of interest.
EDAT- 2024/02/10 10:52
MHDA- 2024/02/10 10:53
PMCR- 2024/01/26
CRDT- 2024/02/10 01:03
PHST- 2023/11/29 00:00 [received]
PHST- 2024/01/18 00:00 [revised]
PHST- 2024/01/24 00:00 [accepted]
PHST- 2024/02/10 10:53 [medline]
PHST- 2024/02/10 10:52 [pubmed]
PHST- 2024/02/10 01:03 [entrez]
PHST- 2024/01/26 00:00 [pmc-release]
AID - jcm13030718 [pii]
AID - jcm-13-00718 [pii]
AID - 10.3390/jcm13030718 [doi]
PST - epublish
SO  - J Clin Med. 2024 Jan 26;13(3):718. doi: 10.3390/jcm13030718.