PMID- 38337452
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240212
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 13
IP  - 3
DP  - 2024 Jan 28
TI  - Maternal Fatigue after Postpartum Anemia Treatment with Intravenous Ferric 
      Carboxymaltose vs. Intravenous Ferric Derisomaltose vs. Oral Ferrous Sulphate: A 
      Randomized Controlled Trial.
LID - 10.3390/jcm13030758 [doi]
LID - 758
AB  - (1) Background: Postpartum anemia is a common maternal complication and is 
      recognized as a cause of impaired quality of life, reduced cognitive abilities, 
      and fatigue. Efficient iron supplementation for the treatment of postpartum 
      anemia is an essential component of high-quality maternal care. The optimal mode 
      of iron supplementation has not been determined yet, whether oral or intravenous. 
      The objective of this study was to compare postpartum anemia treatment with 
      intravenous ferric carboxymaltose, intravenous ferric derisomaltose, and oral 
      ferrous sulfate. (2) Methods: A single-center, open-label, randomized controlled 
      trial. Women with hemoglobin < 100 g/L within 48 h postpartum were randomly 
      allocated to receive intravenous ferric carboxymaltose, intravenous ferric 
      derisomaltose, or oral ferrous sulfate. Intravenous iron was given in one or two 
      doses, while ferrous sulfate was given as two 80 mg tablets once daily. The 
      primary outcome was maternal fatigue measured by the Multidimensional Fatigue 
      Inventory (MFI) six weeks postpartum. Hemoglobin, ferritin, and transferrin 
      saturation levels were analyzed as secondary outcomes. A Kruskal-Wallis test was 
      used for group comparison (p < 0.05 significant). (3) Results: Three hundred 
      women were included. The MFI score at six weeks postpartum did not differ between 
      groups (median 38 (inter-quartile range (IQR) 29-47) in the ferric carboxymaltose 
      group, median 34 (IQR 26-42) in the ferric derisomaltose group, and median 36 
      (IQR 25-47) in the ferrous sulfate group; p = 0.26). Participants receiving oral 
      iron had lower levels of hemoglobin (135 (131-139) vs. 134 (129-139) vs. 131 
      (125-137) g/L; p = 0.008), ferritin (273 (198-377) vs. 187 (155-246) vs. 24 
      (17-37) microg/L; p < 0.001) and transferrin saturation (34 (28-38) vs. 30 (23-37) 
      vs. 24 (17-37) %; p < 0.001) than those receiving ferric carboxymaltose or ferric 
      derisomaltose. (4) Conclusions: Intravenous ferric carboxymaltose, intravenous 
      ferric derisomaltose, and oral ferrous sulfate had similar impacts on maternal 
      fatigue at six weeks postpartum despite improved laboratory parameters in the 
      intravenous groups.
FAU - Bombac Tavcar, Lea
AU  - Bombac Tavcar L
AUID- ORCID: 0009-0007-5173-1750
AD  - Department of Perinatology, Division of Gynecology and Obstetrics, University 
      Medical Centre Ljubljana, Slajmerjeva 3, 1000 Ljubljana, Slovenia.
AD  - Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, 
      Slovenia.
FAU - Hrobat, Hana
AU  - Hrobat H
AD  - Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, 
      Slovenia.
FAU - Gornik, Lea
AU  - Gornik L
AD  - Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, 
      Slovenia.
FAU - Preloznik Zupan, Irena
AU  - Preloznik Zupan I
AD  - Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, 
      Slovenia.
AD  - Department of Hematology, University Medical Centre Ljubljana, Zaloska 7, 1000 
      Ljubljana, Slovenia.
FAU - Vidmar Simic, Marijana
AU  - Vidmar Simic M
AD  - Department of Perinatology, Division of Gynecology and Obstetrics, University 
      Medical Centre Ljubljana, Slajmerjeva 3, 1000 Ljubljana, Slovenia.
FAU - Peclin, Polona
AU  - Peclin P
AD  - Department of Perinatology, Division of Gynecology and Obstetrics, University 
      Medical Centre Ljubljana, Slajmerjeva 3, 1000 Ljubljana, Slovenia.
FAU - Kavsek, Gorazd
AU  - Kavsek G
AUID- ORCID: 0000-0001-5223-7008
AD  - Department of Perinatology, Division of Gynecology and Obstetrics, University 
      Medical Centre Ljubljana, Slajmerjeva 3, 1000 Ljubljana, Slovenia.
FAU - Lucovnik, Miha
AU  - Lucovnik M
AD  - Department of Perinatology, Division of Gynecology and Obstetrics, University 
      Medical Centre Ljubljana, Slajmerjeva 3, 1000 Ljubljana, Slovenia.
AD  - Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, 
      Slovenia.
LA  - eng
PT  - Journal Article
DEP - 20240128
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC10856024
OTO - NOTNLM
OT  - fatigue
OT  - intravenous iron treatment
OT  - oral iron replacement
OT  - patient-centered outcome
OT  - postpartum anemia
COIS- L.B.T. and M.L. received fees from Ewopharma for leading an anemia in pregnancy 
      and postpartum workshop after study completion (Anaemia Talks 8 June 2022, local 
      meeting, Ljubljana, Slovenia). The other authors declare no conflicts of 
      interest.
EDAT- 2024/02/10 10:50
MHDA- 2024/02/10 10:51
PMCR- 2024/01/28
CRDT- 2024/02/10 01:03
PHST- 2023/12/07 00:00 [received]
PHST- 2024/01/22 00:00 [revised]
PHST- 2024/01/24 00:00 [accepted]
PHST- 2024/02/10 10:51 [medline]
PHST- 2024/02/10 10:50 [pubmed]
PHST- 2024/02/10 01:03 [entrez]
PHST- 2024/01/28 00:00 [pmc-release]
AID - jcm13030758 [pii]
AID - jcm-13-00758 [pii]
AID - 10.3390/jcm13030758 [doi]
PST - epublish
SO  - J Clin Med. 2024 Jan 28;13(3):758. doi: 10.3390/jcm13030758.