PMID- 38338785
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 25
IP  - 3
DP  - 2024 Jan 25
TI  - Exosomal Osteoclast-Derived miRNA in Rheumatoid Arthritis: From Their 
      Pathogenesis in Bone Erosion to New Therapeutic Approaches.
LID - 10.3390/ijms25031506 [doi]
LID - 1506
AB  - Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation, 
      pain, and ultimately, bone erosion of the joints. The causes of this disease are 
      multifactorial, including genetic factors, such as the presence of the human 
      leukocyte antigen (HLA)-DRB1*04 variant, alterations in the microbiota, or immune 
      factors including increased cytotoxic T lymphocytes (CTLs), neutrophils, or 
      elevated M1 macrophages which, taken together, produce high levels of 
      pro-inflammatory cytokines. In this review, we focused on the function exerted by 
      osteoclasts on osteoblasts and other osteoclasts by means of the release of 
      exosomal microRNAs (miRNAs). Based on a thorough revision, we classified these 
      molecules into three categories according to their function: osteoclast 
      inhibitors (miR-23a, miR-29b, and miR-214), osteoblast inhibitors (miR-22-3p, 
      miR-26a, miR-27a, miR-29a, miR-125b, and miR-146a), and osteoblast enhancers 
      (miR-20a, miR-34a, miR-96, miR-106a, miR-142, miR-199a, miR-324, and miR-486b). 
      Finally, we analyzed potential therapeutic targets of these exosomal miRNAs, such 
      as the use of antagomiRs, blockmiRs, agomiRs and competitive endogenous RNAs 
      (ceRNAs), which are already being tested in murine and ex vivo models of RA. 
      These strategies might have an important role in reestablishing the regulation of 
      osteoclast and osteoblast differentiation making progress in the development of 
      personalized medicine.
FAU - Pascual-Garcia, Sandra
AU  - Pascual-Garcia S
AUID- ORCID: 0000-0002-0536-1185
AD  - Department of Biotechnology, University of Alicante, 03690 San Vicente del 
      Raspeig, Spain.
FAU - Martinez-Peinado, Pascual
AU  - Martinez-Peinado P
AUID- ORCID: 0000-0003-4370-5468
AD  - Department of Biotechnology, University of Alicante, 03690 San Vicente del 
      Raspeig, Spain.
FAU - Pujalte-Satorre, Carolina
AU  - Pujalte-Satorre C
AD  - Department of Biotechnology, University of Alicante, 03690 San Vicente del 
      Raspeig, Spain.
FAU - Navarro-Sempere, Alicia
AU  - Navarro-Sempere A
AD  - Department of Biotechnology, University of Alicante, 03690 San Vicente del 
      Raspeig, Spain.
FAU - Esteve-Girbes, Jorge
AU  - Esteve-Girbes J
AD  - Department of Legal Studies of the State, University of Alicante, 03690 San 
      Vicente del Raspeig, Spain.
FAU - Lopez-Jaen, Ana B
AU  - Lopez-Jaen AB
AD  - Department of Biotechnology, University of Alicante, 03690 San Vicente del 
      Raspeig, Spain.
FAU - Javaloyes-Anton, Juan
AU  - Javaloyes-Anton J
AD  - Department of Physics, Systems Engineering and Signal Theory, University of 
      Alicante, 03690 San Vicente del Raspeig, Spain.
FAU - Cobo-Velacoracho, Raul
AU  - Cobo-Velacoracho R
AD  - Department of Biotechnology, University of Alicante, 03690 San Vicente del 
      Raspeig, Spain.
FAU - Navarro-Blasco, Francisco J
AU  - Navarro-Blasco FJ
AD  - Department of Biotechnology, University of Alicante, 03690 San Vicente del 
      Raspeig, Spain.
AD  - Rheumatology Unit, University General Hospital of Elche, 03203 Elche, Spain.
FAU - Sempere-Ortells, Jose M
AU  - Sempere-Ortells JM
AD  - Department of Biotechnology, University of Alicante, 03690 San Vicente del 
      Raspeig, Spain.
LA  - eng
GR  - CIGE/2021/162/Generalitat Valenciana/
GR  - GRE21-17/University of Alicante/
PT  - Journal Article
PT  - Review
DEP - 20240125
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (MicroRNAs)
RN  - 0 (Antagomirs)
RN  - 0 (MIRN214 microRNA, human)
RN  - 0 (MIRN324 microRNA, human)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - Osteoclasts/pathology
MH  - *MicroRNAs/genetics
MH  - *Arthritis, Rheumatoid/genetics/pathology
MH  - Osteoblasts/pathology
MH  - Macrophages/pathology
MH  - Antagomirs
PMC - PMC10855630
OTO - NOTNLM
OT  - exosomes
OT  - miRNAs
OT  - osteoblast
OT  - osteoclast
OT  - rheumatoid arthritis
COIS- The authors declare no conflict of interest.
EDAT- 2024/02/10 10:49
MHDA- 2024/02/10 10:50
PMCR- 2024/01/25
CRDT- 2024/02/10 01:11
PHST- 2023/12/20 00:00 [received]
PHST- 2024/01/19 00:00 [revised]
PHST- 2024/01/23 00:00 [accepted]
PHST- 2024/02/10 10:50 [medline]
PHST- 2024/02/10 10:49 [pubmed]
PHST- 2024/02/10 01:11 [entrez]
PHST- 2024/01/25 00:00 [pmc-release]
AID - ijms25031506 [pii]
AID - ijms-25-01506 [pii]
AID - 10.3390/ijms25031506 [doi]
PST - epublish
SO  - Int J Mol Sci. 2024 Jan 25;25(3):1506. doi: 10.3390/ijms25031506.