PMID- 38339807
OWN - NLM
STAT- Publisher
LR  - 20240210
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
DP  - 2024 Feb 9
TI  - Association of non-essential metals with Chinese schizophrenia: A case-control 
      study.
LID - 10.1111/eip.13505 [doi]
AB  - BACKGROUND: The potential link between environmental pollutants, including 
      metals, and schizophrenia development remains debated. This study aimed to 
      explore the association between plasma levels of three non-essential 
      metals-barium (Ba), tungsten (W), and uranium (U)-and schizophrenia risk among 
      Chinese individuals. METHOD: We recruited a total of 221 patients and 219 healthy 
      controls. Plasma levels of three non-essential metals were measured using 
      inductively coupled plasma mass spectrometry. We employed unconditional logistic 
      regression and Bayesian kernel machine regression (BKMR) to explore the 
      relationship between exposure to multiple metals and the risk of schizophrenia. 
      RESULTS: Logistic regression analysis revealed that the highest quartile (Q4) of 
      W had an odds ratio (OR) of 1.87 (95% CI: 1.08-3.21) compared to the lowest 
      quartile (Q1), with a significant P-trend of 0.017. For U, the ORs (95% CI) for 
      Q2, Q3, and Q4 were 2.06 (1.19-3.56), 1.99 (1.15-3.44), and 1.74 (1.00-3.00), 
      respectively. BKMR analyses revealed a progressive increase in the risk of 
      schizophrenia with increasing cumulative levels of the three metals at 
      concentrations below 35%, with U playing a major role in this association. U 
      showed a non-linear positive correlation with schizophrenia, particularly at the 
      75th percentile level. Moreover, potential interactions were observed between W 
      and Ba, as well as between W and U. CONCLUSION: Higher plasma W and U 
      concentrations were positively associated with the risk of schizophrenia, which 
      was potentially related to the severity of symptoms in schizophrenic patients.
CI  - (c) 2024 John Wiley & Sons Australia, Ltd.
FAU - Li, Jiale
AU  - Li J
AD  - Department of Epidemiology and Health Statistics, School of Public Health of 
      Guangxi Medical University, Nanning, China.
FAU - Chen, Jiewen
AU  - Chen J
AD  - Department of Epidemiology and Health Statistics, School of Public Health of 
      Guangxi Medical University, Nanning, China.
FAU - Shen, Bing
AU  - Shen B
AD  - Department of Epidemiology and Health Statistics, School of Public Health of 
      Guangxi Medical University, Nanning, China.
FAU - Lu, Rumei
AU  - Lu R
AD  - Department of Epidemiology and Health Statistics, School of Public Health of 
      Guangxi Medical University, Nanning, China.
FAU - He, Wanting
AU  - He W
AD  - Department of Epidemiology and Health Statistics, School of Public Health of 
      Guangxi Medical University, Nanning, China.
FAU - Huang, Xiaolan
AU  - Huang X
AD  - Department of Epidemiology and Health Statistics, School of Public Health of 
      Guangxi Medical University, Nanning, China.
FAU - Li, Dongmei
AU  - Li D
AD  - Department of Epidemiology and Health Statistics, School of Public Health of 
      Guangxi Medical University, Nanning, China.
FAU - Su, Li
AU  - Su L
AUID- ORCID: 0000-0002-1435-9669
AD  - Department of Epidemiology and Health Statistics, School of Public Health of 
      Guangxi Medical University, Nanning, China.
FAU - Long, Jianxiong
AU  - Long J
AD  - Department of Epidemiology and Health Statistics, School of Public Health of 
      Guangxi Medical University, Nanning, China.
AD  - Guangxi Colleges and Universities Key Laboratory of Prevention and Control of 
      Highly Prevalent Diseases, Guangxi Medical University, Nanning, China.
LA  - eng
GR  - 82060615/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20240209
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - barium
OT  - schizophrenia
OT  - tungsten
OT  - uranium
EDAT- 2024/02/10 10:52
MHDA- 2024/02/10 10:52
CRDT- 2024/02/10 02:22
PHST- 2023/10/19 00:00 [revised]
PHST- 2023/07/22 00:00 [received]
PHST- 2024/01/24 00:00 [accepted]
PHST- 2024/02/10 10:52 [medline]
PHST- 2024/02/10 10:52 [pubmed]
PHST- 2024/02/10 02:22 [entrez]
AID - 10.1111/eip.13505 [doi]
PST - aheadofprint
SO  - Early Interv Psychiatry. 2024 Feb 9. doi: 10.1111/eip.13505.