PMID- 38340587
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 121
DP  - 2024 Jun
TI  - Intrinsic capacity and multimorbidity predicting incident disability-Insights 
      from the I-Lan Longitudinal Aging Study.
PG  - 105357
LID - S0167-4943(24)00033-5 [pii]
LID - 10.1016/j.archger.2024.105357 [doi]
AB  - OBJECTIVES: This longitudinal cohort study aimed to examine the effect of 
      intrinsic capacity (IC) and multimorbidity on the development of new 
      disabilities. METHODS: The study utilized data from 1,009 participants without 
      disabilities from the I-Lan Longitudinal Aging Study. Multivariable logistic 
      regressions were employed to assess the predictive capability of IC (ranging from 
      0 to 100) and multimorbidity for incident disability over a 7-year follow-up 
      period. RESULTS: Both low IC (OR 4.9, 95 % CI 2.1-11.1, p < 0.001) and 
      multimorbidity (OR 4.5, 95 % CI 2.2-9.2, p < 0.001) significantly predicted 
      incident disability over the 7-year period. A one-point increase in IC reduced 
      the risk of incident disability by 10 % (OR 0.9, 95 % CI 0.8-0.9, p < 0.001). 
      Among IC subdomains, both better locomotion (OR 0.96, 95 % CI 0.94-0.99, p = 
      0.014) and psychology (OR 0.97, 95 %CI 0.94-1.00, p = 0.049) significantly 
      reduced the risk of incident disability. Rapid declines in IC significantly 
      predicted incident disability (OR 4.1, 95 % CI 1.8-9.3, p = 0.001), whereas the 
      onset of new multimorbidity or changes in the number of chronic conditions did 
      not demonstrate a significant association with incident disability. The 
      interaction terms between IC and multimorbidity, both categorically (low IC * 
      multimorbidity, p = 0.959) and numerically (IC (per point) * multimorbidity, p = 
      0.660) were all statistically insignificant. CONCLUSIONS: IC exhibited better 
      predictive capacity for 7-year incident disability compared to multimorbidity, so 
      health care services targeting older adults should adopt an integrated care 
      approach that combines both function- and disease-centric strategies.
CI  - Copyright (c) 2024 Elsevier B.V. All rights reserved.
FAU - Lee, Wei-Ju
AU  - Lee WJ
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan; Department of Geriatric Medicine, National Yang Ming 
      Chiao Tung University, School of Medicine, Taipei, Taiwan; Department of Family 
      Medicine, Taipei Veterans General Hospital Yuanshan Branch, Yi-Lan, Taiwan. 
      Electronic address: wjlee@nycu.edu.tw.
FAU - Peng, Li-Ning
AU  - Peng LN
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan; Department of Geriatric Medicine, National Yang Ming 
      Chiao Tung University, School of Medicine, Taipei, Taiwan; Center for Geriatrics 
      and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Lin, Ming-Hsien
AU  - Lin MH
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan; Department of Geriatric Medicine, National Yang Ming 
      Chiao Tung University, School of Medicine, Taipei, Taiwan; Center for Geriatrics 
      and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Loh, Ching-Hui
AU  - Loh CH
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan; Department of Geriatric Medicine, National Yang Ming 
      Chiao Tung University, School of Medicine, Taipei, Taiwan; Center of Health and 
      Aging, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation, Hualien, 
      Taiwan.
FAU - Hsiao, Fei-Yuan
AU  - Hsiao FY
AD  - Graduate Institute of Clinical Pharmacy, National Taiwan University, Taipei, 
      Taiwan.
FAU - Chen, Liang-Kung
AU  - Chen LK
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan; Department of Geriatric Medicine, National Yang Ming 
      Chiao Tung University, School of Medicine, Taipei, Taiwan; Center for Geriatrics 
      and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei 
      Municipal Gan-Dau Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20240203
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
SB  - IM
MH  - Humans
MH  - Aged
MH  - Longitudinal Studies
MH  - *Multimorbidity
MH  - Aging
MH  - Cohort Studies
MH  - *Disabled Persons/psychology
OTO - NOTNLM
OT  - Disability
OT  - Healthy aging
OT  - Intrinsic capacity
OT  - Multimorbidity
COIS- Declaration of competing interest The authors declare no competing interests.
EDAT- 2024/02/11 07:42
MHDA- 2024/04/08 06:43
CRDT- 2024/02/10 18:10
PHST- 2023/11/25 00:00 [received]
PHST- 2024/01/28 00:00 [revised]
PHST- 2024/01/29 00:00 [accepted]
PHST- 2024/04/08 06:43 [medline]
PHST- 2024/02/11 07:42 [pubmed]
PHST- 2024/02/10 18:10 [entrez]
AID - S0167-4943(24)00033-5 [pii]
AID - 10.1016/j.archger.2024.105357 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2024 Jun;121:105357. doi: 10.1016/j.archger.2024.105357. 
      Epub 2024 Feb 3.