PMID- 38340956
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240226
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 247
DP  - 2024 Apr 1
TI  - Impact of caloric restriction on oxidative stress and key glycolytic enzymes in 
      the cerebral cortex, liver and kidney of old and middle-aged mice.
PG  - 109859
LID - S0028-3908(24)00025-X [pii]
LID - 10.1016/j.neuropharm.2024.109859 [doi]
AB  - Caloric restriction (CR) is proposed as a strategy to prevent age-related 
      alterations like impaired glucose metabolism and intensification of oxidative 
      stress. In this study, we examined effects of aging and CR on the activities of 
      glycolytic enzymes and parameters of oxidative stress in the cerebral cortex, 
      liver, and kidney of middle-aged (9 months old) and old (18 months old) C57BL6/N 
      mice. Control middle-aged and old mice were fed ad libitum (AL groups), whereas 
      age-matched CR groups were subjected to CR (70% of individual ad libitum food 
      intake) for 6 and 12 months, respectively. There were no significant differences 
      in the activities of key glycolytic and antioxidant enzymes and oxidative stress 
      indices between the cortices of middle-aged and old AL mice. The livers and 
      kidneys of old AL mice showed higher activity of glucose-6-phosphate 
      dehydrogenase, an enzyme that produces NADPH in the pentose phosphate pathway, 
      compared to those of middle-aged mice. CR regimen modulated some biochemical 
      parameters in middle-aged but not in old mice. In particular, CR decreased 
      oxidative stress intensity in the liver and kidney but had no effects on those 
      parameters in the cerebral cortex. In the liver, CR led to lower activities of 
      glycolytic enzymes, whereas its effect was the opposite in the kidney. The 
      results suggest that during physiological aging there is no significant 
      intensification of oxidative stress and glycolysis decline in mouse tissues 
      during the transition from middle to old age. The CR regimen has tissue-specific 
      effects and improves the metabolic state of middle-aged mice. This article is 
      part of the Special Issue on "Ukrainian Neuroscience".
CI  - Copyright (c) 2024. Published by Elsevier Ltd.
FAU - Vatashchuk, Myroslava V
AU  - Vatashchuk MV
AD  - Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian 
      National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine.
FAU - Hurza, Viktoriia V
AU  - Hurza VV
AD  - Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian 
      National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine.
FAU - Stefanyshyn, Nadiia
AU  - Stefanyshyn N
AD  - Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian 
      National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine.
FAU - Bayliak, Maria M
AU  - Bayliak MM
AD  - Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian 
      National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine.
FAU - Gospodaryov, Dmytro V
AU  - Gospodaryov DV
AD  - Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian 
      National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine.
FAU - Garaschuk, Olga
AU  - Garaschuk O
AD  - Department of Neurophysiology, University of Tubingen, Tubingen, 72074, Germany. 
      Electronic address: olga.garaschuk@uni-tuebingen.de.
FAU - Lushchak, Volodymyr I
AU  - Lushchak VI
AD  - Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian 
      National University, 57 Shevchenko Str., Ivano-Frankivsk, 76018, Ukraine; 
      Research and Development University, 13a Shota Rustaveli Str., Ivano-Frankivsk, 
      76018, Ukraine. Electronic address: volodymyr.lushchak@pnu.edu.ua.
LA  - eng
PT  - Journal Article
DEP - 20240209
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Caloric Restriction/methods
MH  - *Oxidative Stress/physiology
MH  - Aging/metabolism
MH  - Liver/metabolism
MH  - Kidney
MH  - Glycolysis
MH  - Cerebral Cortex
OTO - NOTNLM
OT  - Aging
OT  - Antioxidant system
OT  - Caloric restriction
OT  - Cerebral cortex
OT  - Glycolysis
OT  - Mice
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/02/11 07:42
MHDA- 2024/02/26 06:44
CRDT- 2024/02/10 19:15
PHST- 2023/10/15 00:00 [received]
PHST- 2023/12/28 00:00 [revised]
PHST- 2024/01/25 00:00 [accepted]
PHST- 2024/02/26 06:44 [medline]
PHST- 2024/02/11 07:42 [pubmed]
PHST- 2024/02/10 19:15 [entrez]
AID - S0028-3908(24)00025-X [pii]
AID - 10.1016/j.neuropharm.2024.109859 [doi]
PST - ppublish
SO  - Neuropharmacology. 2024 Apr 1;247:109859. doi: 10.1016/j.neuropharm.2024.109859. 
      Epub 2024 Feb 9.