PMID- 38341300
OWN - NLM
STAT- MEDLINE
DCOM- 20240315
LR  - 20240315
IS  - 2213-2945 (Print)
IS  - 2213-2953 (Linking)
VI  - 13
IP  - 2
DP  - 2024 Mar-Apr
TI  - Utility of The Paris System (TPS) for upper urinary tract cytopathology: 
      correlation with histology follow-up and UroVysion fluorescence in situ 
      hybridization (FISH) analysis.
PG  - 149-155
LID - S2213-2945(23)00262-4 [pii]
LID - 10.1016/j.jasc.2023.12.003 [doi]
AB  - INTRODUCTION: The Paris System (TPS) provides a uniform reporting system of urine 
      cytology based on well-defined cytologic criteria. Due to their rarity, there are 
      limited data on the utility of TPS in upper urinary tract (UUT) lesions and 
      follow-up histology of cases with abnormal cytology. We aimed to evaluate the 
      utility of TPS for UUT lesions by correlating the cytologic diagnoses using TPS 
      criteria with subsequent histology. Additionally, the diagnostic utility of 
      UroVysion (Abbott) fluorescence in situ hybridization (FISH) was assessed. 
      MATERIALS AND METHODS: A total of 148 UUT cytology specimens were retrospectively 
      identified (2018-2022). Cytologic interpretation was performed using TPS, and 
      then correlated with the findings of concurrent or subsequent histologic 
      specimens. The performance of UroVysion FISH was analyzed. Sensitivity and 
      specificity, positive predictive value (PPV) and negative predictive value (NPV) 
      for detecting high-grade urothelial carcinoma (HGUC) were determined. RESULTS: 
      Among 83 patients who had concurrent or subsequent histologic specimens, 
      cyto-histologic discrepancy was seen in 7 cases (8.4%). The sensitivity, 
      specificity, PPV, and NPV using TPS criteria for detecting HGUC were 87%, and 
      92%, 96.4%, and 73%, respectively. UroVysion FISH was performed in 21 patients 
      with atypical cytologic findings. The sensitivity and specificity of UroVysion 
      for detecting HGUC was 75% and 86%, respectively, while PPV and NPV were 86% and 
      75%, respectively. CONCLUSIONS: In our experience, the application of TPS 
      criteria for reporting upper urinary cytology was reliable at detecting UUT 
      lesions, especially HGUC. UroVysion FISH was a valuable ancillary test for 
      detecting HGUC of UUT.
CI  - Copyright (c) 2023 American Society of Cytopathology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Jia, Liwei
AU  - Jia L
AD  - Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 
      Texas. Electronic address: Liwei.JIa@UTSouthwestern.edu.
FAU - Rood, Tricia
AU  - Rood T
AD  - Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 
      Texas.
FAU - Kirkpatrick, James
AU  - Kirkpatrick J
AD  - Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 
      Texas.
FAU - Sarode, Venetia
AU  - Sarode V
AD  - Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 
      Texas.
LA  - eng
PT  - Journal Article
DEP - 20240103
PL  - United States
TA  - J Am Soc Cytopathol
JT  - Journal of the American Society of Cytopathology
JID - 101613234
SB  - IM
MH  - Humans
MH  - *Urologic Neoplasms/diagnosis/pathology
MH  - *Carcinoma, Transitional Cell/diagnosis/pathology
MH  - *Urinary Bladder Neoplasms/diagnosis/pathology
MH  - Follow-Up Studies
MH  - Retrospective Studies
MH  - In Situ Hybridization, Fluorescence
MH  - *Urinary Tract/pathology
OTO - NOTNLM
OT  - Cytology
OT  - Discrepancy
OT  - Histology
OT  - Upper urinary tract
OT  - UroVysion
OT  - Urothelial carcinoma
EDAT- 2024/02/11 07:42
MHDA- 2024/03/15 06:43
CRDT- 2024/02/10 21:52
PHST- 2023/10/13 00:00 [received]
PHST- 2023/12/24 00:00 [revised]
PHST- 2023/12/28 00:00 [accepted]
PHST- 2024/03/15 06:43 [medline]
PHST- 2024/02/11 07:42 [pubmed]
PHST- 2024/02/10 21:52 [entrez]
AID - S2213-2945(23)00262-4 [pii]
AID - 10.1016/j.jasc.2023.12.003 [doi]
PST - ppublish
SO  - J Am Soc Cytopathol. 2024 Mar-Apr;13(2):149-155. doi: 10.1016/j.jasc.2023.12.003. 
      Epub 2024 Jan 3.