PMID- 38344270
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240213
IS  - 2052-1537 (Print)
IS  - 2052-1537 (Electronic)
VI  - 5
IP  - 18
DP  - 2021 Sep 21
TI  - USE OF ARTIFICIAL CELLS AS DRUG CARRIERS.
PG  - 6672-6692
LID - 10.1039/d1qm00717c [doi]
AB  - Cells are the fundamental functional units of biological systems and mimicking 
      their size, function and complexity is a primary goal in the development of new 
      therapeutic strategies. Recent advances in chemistry, synthetic biology and 
      material science have enabled the development of cell membrane-based drug 
      delivery systems (DDSs), often referred to as "artificial cells" or protocells. 
      Artificial cells can be made by removing functions from natural systems in a 
      top-down manner, or assembly from synthetic, organic or inorganic materials, 
      through a bottom-up approach where simple units are integrated to form more 
      complex structures. This review covers the latest advances in the development of 
      artificial cells as DDSs, highlighting how their designs have been inspired by 
      natural cells or cell membranes. Advancement of artificial cell technologies has 
      led to a set of drug carriers with effective and controlled release of a variety 
      of therapeutics for a range of diseases, and with increasing complexity they will 
      have a greater impact on therapeutic designs.
FAU - Diltemiz, Sibel Emir
AU  - Diltemiz SE
AD  - Department of Bioengineering, Henry Samueli School of Engineering, University of 
      California, Los Angeles, California, USA.
AD  - Department of Chemistry, Eskisehir Technical University, Eskisehir, Turkey.
FAU - Tavafoghi PhD, Maryam
AU  - Tavafoghi PhD M
AD  - Department of Bioengineering, Henry Samueli School of Engineering, University of 
      California, Los Angeles, California, USA.
FAU - Roberto de Barros, Natan
AU  - Roberto de Barros N
AD  - Department of Bioengineering, Henry Samueli School of Engineering, University of 
      California, Los Angeles, California, USA.
AD  - Department of Bioprocess and Biotechnology Engineering, Sao Paulo State 
      University (Unesp), School of Pharmaceutical Sciences, Araraquara, Sao Paulo, 
      Brazil.
FAU - Kanada, Masamitsu
AU  - Kanada M
AD  - Institute for Quantitative Health Science and Engineering (IQ), Department of 
      Pharmacology and Toxicology, College of Human Medicine, Michigan State 
      University, East Lansing, Michigan, USA.
FAU - Heinamaki, Jyrki
AU  - Heinamaki J
AD  - Institute of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse Str. 1, 
      EE-50411 Tartu, Estonia.
FAU - Contag, Christopher
AU  - Contag C
AD  - Institute for Quantitative Health Science and Engineering (IQ) and Departments of 
      Biomedical Engineering (BME), and Microbiology and Molecular Genetics, Michigan 
      State University, East Lansing, MI 48824, USA.
FAU - Seidlits, Stephanie
AU  - Seidlits S
AD  - Department of Bioengineering, Henry Samueli School of Engineering, University of 
      California, Los Angeles, California, USA.
FAU - Ashammakhi, Nureddin
AU  - Ashammakhi N
AD  - Department of Bioengineering, Henry Samueli School of Engineering, University of 
      California, Los Angeles, California, USA.
AD  - Institute for Quantitative Health Science and Engineering (IQ) and Department of 
      Biomedical Engineering (BME), Michigan State University, East Lansing, MI 48824, 
      USA.
LA  - eng
GR  - UG3 TR003148/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20210716
PL  - England
TA  - Mater Chem Front
JT  - Materials chemistry frontiers
JID - 101683054
PMC - PMC10857888
MID - NIHMS1731306
OTO - NOTNLM
OT  - Artificial cells
OT  - drug delivery
OT  - liposomes
OT  - therapeutic drug delivery
EDAT- 2021/09/21 00:00
MHDA- 2021/09/21 00:01
PMCR- 2024/02/09
CRDT- 2024/02/12 04:20
PHST- 2021/09/21 00:01 [medline]
PHST- 2021/09/21 00:00 [pubmed]
PHST- 2024/02/12 04:20 [entrez]
PHST- 2024/02/09 00:00 [pmc-release]
AID - 10.1039/d1qm00717c [doi]
PST - ppublish
SO  - Mater Chem Front. 2021 Sep 21;5(18):6672-6692. doi: 10.1039/d1qm00717c. Epub 2021 
      Jul 16.