PMID- 38346638
OWN - NLM
STAT- MEDLINE
DCOM- 20240313
LR  - 20240313
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 345
DP  - 2024 Mar 15
TI  - Urinary neonicotinoid concentrations and obesity: A cross-sectional study among 
      Chinese adolescents.
PG  - 123516
LID - S0269-7491(24)00230-6 [pii]
LID - 10.1016/j.envpol.2024.123516 [doi]
AB  - Epidemiological and toxicological studies on neonicotinoids and obesity have been 
      relevant to adults and young children, but data are limited in adolescents. This 
      study aimed to examine the association between urinary neonicotinoid 
      concentrations and obesity measures among Chinese adolescent. A total of 524 
      urine samples from 300 boys (11.3-16.1 years) and 224 girls (12.1-15.8 years) 
      were collected to detect the concentrations of eleven neonicotinoids. Generalized 
      linear regression, weighted quantile sum regression (WQS) and Bayesian kernel 
      machine regression (BKMR) were used to estimate covariate-adjusted associations 
      between detectable neonicotinoids and ten indicators of obesity. Nitenpyram 
      concentration was associated with increased body mass index z-score (beta = 0.170, 
      95% CI: 0.041, 0.299) and greater odds of being general obesity (OR = 2.46, 95% 
      CI: 1.11, 5.46). N-desmethyl- acetamiprid concentration was associated with an 
      increase in waist-to-height ratio (beta = 0.102, 95% CI: 0.029, 0.176) and 
      waist-to-hip ratio (beta = 0.083, 95% CI: 0.011, 0.155). The concentrations of 
      clothianidin (OR = 2.06, 95% CI: 1.10, 3.88) and flonicamid (OR = 2.39, 95% CI: 
      1.07, 5.32) were associated with greater odds of being abdominal obesity. In 
      contrast, the concentrations of imidacloprid (OR = 0.35, 95% CI: 0.14, 0.88) and 
      thiacloprid (OR = 0.28, 95% CI: 0.08, 0.99) were associated with lower odds of 
      being general obesity. The estimates of general obesity and abdominal obesity 
      increased significantly when concentrations of neonicotinoids mixture were at or 
      above the 55th and 65th percentiles, respectively, compared to the 50th 
      percentile concentration. Sex modified the association between nitenpyram and 
      clothianidin and the risk of obesity with a positive association among boys, and 
      a nonsignificant inverse association among girls. The findings suggest that these 
      associations may be mixed and sex-specific.
CI  - Copyright (c) 2024 Elsevier Ltd. All rights reserved.
FAU - Wu, Xu
AU  - Wu X
AD  - School of Public Health, Chongqing Medical University, Chongqing 400016, PR 
      China.
FAU - Liu, Qin
AU  - Liu Q
AD  - School of Public Health, Chongqing Medical University, Chongqing 400016, PR 
      China.
FAU - Li, Yin
AU  - Li Y
AD  - School of Public Health, Chongqing Medical University, Chongqing 400016, PR 
      China.
FAU - Yue, Min
AU  - Yue M
AD  - School of Public Health, Chongqing Medical University, Chongqing 400016, PR 
      China; Chongqing Shapingba Center for Disease Control and Prevention, Chongqing 
      400038, PR China.
FAU - Su, Qian
AU  - Su Q
AD  - School of Public Health, Chongqing Medical University, Chongqing 400016, PR 
      China.
FAU - Luo, Jinzhu
AU  - Luo J
AD  - School of Public Health, Chongqing Medical University, Chongqing 400016, PR 
      China.
FAU - Li, Yang
AU  - Li Y
AD  - School of Public Health, Chongqing Medical University, Chongqing 400016, PR 
      China.
FAU - Zeng, Shaohua
AU  - Zeng S
AD  - China Coal Technology & Engineering Group Chongqing Research Institute, Chongqing 
      400039, PR China.
FAU - Gao, Jieying
AU  - Gao J
AD  - School of Public Health, Chongqing Medical University, Chongqing 400016, PR 
      China. Electronic address: jygao@cqmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20240210
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 2V9906ABKQ (clothianidin)
RN  - 0 (Neonicotinoids)
RN  - 0 (Insecticides)
RN  - 0 (Guanidines)
RN  - 0 (Thiazoles)
SB  - IM
MH  - Male
MH  - Adult
MH  - Child
MH  - Female
MH  - Humans
MH  - Adolescent
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - *Obesity, Abdominal
MH  - Bayes Theorem
MH  - Neonicotinoids
MH  - Obesity/epidemiology
MH  - China/epidemiology
MH  - *Insecticides
MH  - *Guanidines
MH  - *Thiazoles
OTO - NOTNLM
OT  - Adolescents
OT  - Bayesian kernel machine regression
OT  - Neonicotinoids
OT  - Obesity
OT  - Weighted quantile sum regression
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/02/13 00:42
MHDA- 2024/03/13 06:46
CRDT- 2024/02/12 19:16
PHST- 2023/11/29 00:00 [received]
PHST- 2024/02/04 00:00 [revised]
PHST- 2024/02/05 00:00 [accepted]
PHST- 2024/03/13 06:46 [medline]
PHST- 2024/02/13 00:42 [pubmed]
PHST- 2024/02/12 19:16 [entrez]
AID - S0269-7491(24)00230-6 [pii]
AID - 10.1016/j.envpol.2024.123516 [doi]
PST - ppublish
SO  - Environ Pollut. 2024 Mar 15;345:123516. doi: 10.1016/j.envpol.2024.123516. Epub 
      2024 Feb 10.