PMID- 38346902
OWN - NLM
STAT- MEDLINE
DCOM- 20240311
LR  - 20240311
IS  - 2373-2822 (Electronic)
IS  - 2373-2822 (Linking)
VI  - 11
IP  - 3
DP  - 2024 Mar
TI  - Lingual Taste Nerve Transection Alters Food Selection, Relative Macronutrient 
      Intake, and Meal Patterns in Rats Consuming a Cafeteria Diet without Changing 
      Total Energy Intake.
LID - ENEURO.0393-23.2024 [pii]
LID - 10.1523/ENEURO.0393-23.2024 [doi]
AB  - The control of ingestive behavior is complex and involves input from many 
      different sources, including the gustatory system. Signals transmitted via the 
      taste nerves trigger responses that promote or discourage ingestion. The lingual 
      taste nerves innervate 70% of taste buds, yet their role in the control of food 
      selection and intake remarkably remains relatively underinvestigated. Here we 
      used our custom five-item Food Choice Monitor to compare postsurgical behavioral 
      responses to chow and a five-choice cafeteria diet (CAF) between male rats that 
      had sham surgery (SHAM) or histologically verified transection of the chorda 
      tympani and glossopharyngeal nerves (2NX). Compared with SHAM rats, 2NX rats ate 
      significantly more of the high-fat CAF foods. The altered food choices led to 
      dramatically increased fat intake and substantially reduced carbohydrate intake 
      by 2NX vs SHAM rats. Furthermore, whether offered chow or CAF, 2NX rats ate 
      fewer, larger meals each day. Eating rates implied that, compared with SHAM, 2NX 
      rats were equally motivated to consume CAF but less motivated to eat chow. Even 
      with these differences, energy intake and weight gain trajectories remained 
      similar between SHAM and 2NX rats. Although some rats experienced CAF before 
      surgery, contrary to our expectations, the effects of prior CAF experience on 
      postsurgical eating were minimal. In conclusion, although total energy intake was 
      unaffected, our results clearly indicate that information from one or both 
      lingual taste nerves has a critical role in food selection, regulation of 
      macronutrient intake, and meal termination but not long-term energy balance.
CI  - Copyright (c) 2024 Cawthon et al.
FAU - Cawthon, Carolina R
AU  - Cawthon CR
AD  - Department of Psychology, Program in Neuroscience, Florida State University, 
      Tallahassee, Florida 32306.
FAU - Blonde, Ginger D
AU  - Blonde GD
AD  - Department of Psychology, Program in Neuroscience, Florida State University, 
      Tallahassee, Florida 32306.
FAU - Spector, Alan C
AU  - Spector AC
AUID- ORCID: 0000-0001-6817-6334
AD  - Department of Psychology, Program in Neuroscience, Florida State University, 
      Tallahassee, Florida 32306 spector@psy.fsu.edu.
LA  - eng
GR  - R21 DC021498/DC/NIDCD NIH HHS/United States
GR  - T32 DC000044/DC/NIDCD NIH HHS/United States
PT  - Journal Article
DEP - 20240307
PL  - United States
TA  - eNeuro
JT  - eNeuro
JID - 101647362
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - *Food Preferences/physiology
MH  - *Taste/physiology
MH  - Diet
MH  - Energy Intake
MH  - Eating
MH  - Feeding Behavior/physiology
PMC - PMC10921256
OTO - NOTNLM
OT  - cafeteria diet
OT  - chorda tympani nerve
OT  - food choice
OT  - glossopharyngeal nerve
OT  - meal patterns
OT  - taste
COIS- None of the authors has any conflicts of interest to report. A.C.S. is on the 
      Scientific Advisory Board of Gila Therapeutics.
EDAT- 2024/02/13 00:42
MHDA- 2024/03/11 06:44
PMCR- 2024/03/01
CRDT- 2024/02/12 21:37
PHST- 2023/10/07 00:00 [received]
PHST- 2024/01/19 00:00 [revised]
PHST- 2024/02/02 00:00 [accepted]
PHST- 2024/03/11 06:44 [medline]
PHST- 2024/02/13 00:42 [pubmed]
PHST- 2024/02/12 21:37 [entrez]
PHST- 2024/03/01 00:00 [pmc-release]
AID - ENEURO.0393-23.2024 [pii]
AID - eneuro-11-ENEURO.0393-23.2024 [pii]
AID - 10.1523/ENEURO.0393-23.2024 [doi]
PST - epublish
SO  - eNeuro. 2024 Mar 7;11(3):ENEURO.0393-23.2024. doi: 10.1523/ENEURO.0393-23.2024. 
      Print 2024 Mar.