PMID- 38347201
OWN - NLM
STAT- MEDLINE
DCOM- 20240410
LR  - 20240410
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Linking)
VI  - 27
IP  - 4
DP  - 2024 Apr
TI  - Independent inhibitory control mechanisms for aggressive motivation and action.
PG  - 702-715
LID - 10.1038/s41593-023-01563-6 [doi]
AB  - Social behaviors often consist of a motivational phase followed by action. Here 
      we show that neurons in the ventromedial hypothalamus ventrolateral area (VMHvl) 
      of mice encode the temporal sequence of aggressive motivation to action. The 
      VMHvl receives local inhibitory input (VMHvl shell) and long-range input from the 
      medial preoptic area (MPO) with functional coupling to neurons with specific 
      temporal profiles. Encoding models reveal that during aggression, VMHvl 
      shell(vgat+) activity peaks at the start of an attack, whereas activity from the 
      MPO-VMHvl(vgat+) input peaks at specific interaction endpoints. Activation of the 
      MPO-VMHvl(vgat+) input promotes and prolongs a low motivation state, whereas 
      activation of VMHvl shell(vgat+) results in action-related deficits, acutely 
      terminating attack. Moreover, stimulation of MPO-VMHvl(vgat+) input is positively 
      valenced and anxiolytic. Together, these data demonstrate how distinct inhibitory 
      inputs to the hypothalamus can independently gate the motivational and action 
      phases of aggression through a single locus of control.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.
FAU - Minakuchi, Tomohito
AU  - Minakuchi T
AUID- ORCID: 0009-0008-9013-3275
AD  - Princeton Neuroscience Institute, Princeton, NJ, USA.
FAU - Guthman, Eartha Mae
AU  - Guthman EM
AD  - Princeton Neuroscience Institute, Princeton, NJ, USA.
FAU - Acharya, Preeta
AU  - Acharya P
AD  - Princeton Neuroscience Institute, Princeton, NJ, USA.
FAU - Hinson, Justin
AU  - Hinson J
AD  - Princeton Neuroscience Institute, Princeton, NJ, USA.
FAU - Fleming, Weston
AU  - Fleming W
AD  - Princeton Neuroscience Institute, Princeton, NJ, USA.
FAU - Witten, Ilana B
AU  - Witten IB
AUID- ORCID: 0000-0003-0548-2160
AD  - Princeton Neuroscience Institute, Princeton, NJ, USA.
FAU - Oline, Stefan N
AU  - Oline SN
AD  - Princeton Neuroscience Institute, Princeton, NJ, USA.
FAU - Falkner, Annegret L
AU  - Falkner AL
AUID- ORCID: 0000-0001-9756-7887
AD  - Princeton Neuroscience Institute, Princeton, NJ, USA. afalkner@princeton.edu.
LA  - eng
GR  - R00MH109674/U.S. Department of Health & Human Services | NIH | National Institute 
      of Mental Health (NIMH)/
GR  - DP2MH126375/U.S. Department of Health & Human Services | NIH | National Institute 
      of Mental Health (NIMH)/
GR  - R01MH126035/U.S. Department of Health & Human Services | NIH | National Institute 
      of Mental Health (NIMH)/
GR  - F32MH126562/U.S. Department of Health & Human Services | NIH | National Institute 
      of Mental Health (NIMH)/
GR  - NA/Heiwa Nakajima Foundation (HNF)/
PT  - Journal Article
DEP - 20240212
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Aggression/physiology
MH  - *Motivation
MH  - Social Behavior
MH  - Hypothalamus/physiology
MH  - Neurons/physiology
EDAT- 2024/02/13 00:42
MHDA- 2024/04/10 06:42
CRDT- 2024/02/12 23:29
PHST- 2022/11/07 00:00 [received]
PHST- 2023/12/19 00:00 [accepted]
PHST- 2024/04/10 06:42 [medline]
PHST- 2024/02/13 00:42 [pubmed]
PHST- 2024/02/12 23:29 [entrez]
AID - 10.1038/s41593-023-01563-6 [pii]
AID - 10.1038/s41593-023-01563-6 [doi]
PST - ppublish
SO  - Nat Neurosci. 2024 Apr;27(4):702-715. doi: 10.1038/s41593-023-01563-6. Epub 2024 
      Feb 12.