PMID- 38347378
OWN - NLM
STAT- Publisher
LR  - 20240212
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
DP  - 2024 Feb 12
TI  - MCM6 Inhibits Decidualization via Cross-Talking with ERK Pathway in Human 
      Endometrial Stromal Cells.
LID - 10.1007/s43032-024-01463-5 [doi]
AB  - Decidualization plays an important role in the implantation of the embryo, but 
      the molecular action implicated in this process is not completely known. Herein, 
      we found that, compared with the proliferative endometrial tissues, the 
      expression of minichromosome maintenance complex component 6 (MCM6) was markedly 
      decreased in the secretory endometrial tissues. To verify the function of MCM6 in 
      decidualization, in vitro decidualization model was constructed by treating human 
      endometrial stromal cells (HESCs) with estrogen (E2) and progesterone (P4). 
      Consistently, MCM6 level was downregulated in E2P4-treated HESCs. Administration 
      of E2P4 accumulated HESCs in G1 cell cycle phase, leading to cell growth 
      suppression. Ectopic expression of MCM6 promoted the transition of G1/S and 
      restored the proliferation of HESCs that were inhibited by E2P4. MCM6 
      overexpression led to aberrant activation of extracellular signal-regulated 
      kinase (ERK) and treatment with ERK agonist Ro 67-7476 restored MCM6 expression 
      and cell proliferation inhibited by E2P4. Our data suggested that MCM6/ERK 
      feedback loop plays a negative role in E2P4-induced decidualization and implies 
      that MCM6 may be a promising target for meliorating uterine receptivity.
CI  - (c) 2024. The Author(s), under exclusive licence to Society for Reproductive 
      Investigation.
FAU - Jiang, Yaling
AU  - Jiang Y
AUID- ORCID: 0000-0003-2237-6650
AD  - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of 
      Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for 
      Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher 
      Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China. 3418153001@qq.com.
FAU - Xue, Yuan
AU  - Xue Y
AD  - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of 
      Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for 
      Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher 
      Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Yuan, Xinhua
AU  - Yuan X
AD  - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of 
      Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for 
      Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher 
      Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Ye, Shengqin
AU  - Ye S
AD  - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of 
      Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for 
      Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher 
      Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Liu, Mingxing
AU  - Liu M
AD  - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of 
      Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for 
      Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher 
      Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Shi, Yu
AU  - Shi Y
AD  - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of 
      Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for 
      Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher 
      Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
FAU - Zhou, Hua
AU  - Zhou H
AD  - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of 
      Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for 
      Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher 
      Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated 
      Hospital of Guangzhou Medical University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20240212
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
SB  - IM
OTO - NOTNLM
OT  - Decidualization
OT  - ERK
OT  - Endometrial stromal cells
OT  - MCM6
OT  - Mechanism
EDAT- 2024/02/13 00:42
MHDA- 2024/02/13 00:42
CRDT- 2024/02/12 23:37
PHST- 2023/09/18 00:00 [received]
PHST- 2024/01/12 00:00 [accepted]
PHST- 2024/02/13 00:42 [medline]
PHST- 2024/02/13 00:42 [pubmed]
PHST- 2024/02/12 23:37 [entrez]
AID - 10.1007/s43032-024-01463-5 [pii]
AID - 10.1007/s43032-024-01463-5 [doi]
PST - aheadofprint
SO  - Reprod Sci. 2024 Feb 12. doi: 10.1007/s43032-024-01463-5.