PMID- 38348279
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240214
IS  - 1178-7031 (Print)
IS  - 1178-7031 (Electronic)
IS  - 1178-7031 (Linking)
VI  - 17
DP  - 2024
TI  - Pyroptosis in Osteoarthritis: Molecular Mechanisms and Therapeutic Implications.
PG  - 791-803
LID - 10.2147/JIR.S445573 [doi]
AB  - Osteoarthritis (OA) is a chronic disease that causes pain and functional 
      impairment by affecting joint tissue. Its global impact is noteworthy, causing 
      significant economic losses and property damage. Despite extensive research, the 
      underlying pathogenesis of OA remain an area of ongoing investigation. It has 
      recently been discovered that the OA progression is significantly influenced by 
      pyroptosis. Pyroptosis is a complex process that involves three pathways 
      culminating in the assembly of Gasdermin-D (GSDMD)-N-terminal (GSDMD-NT) into 
      pores through aggregation on the plasma membrane. The aggregation of GSDMD-NT 
      proteins stimulates the release of inflammatory mediators, such as Interleukin-1beta 
      (IL-1beta), Interleukin-18 (IL-18), and Matrix Metallopeptidase 13 (MMP13), 
      ultimately leading to cellular lysis. The pyroptosis process in specific cells, 
      including synovial macrophages, fibroblast-like synoviocytes (FLS), chondrocytes, 
      and subchondral osteoblasts, contributs factor to the development of OA. 
      Currently, the specific cells that undergo pyroptosis first are not yet fully 
      understood, and it remains unknown whether pyroptosis in one cell can trigger the 
      same process in other cells. Therefore, targeting pyroptosis could potentially 
      offer a novel treatment approach for OA patients. We present a comprehensive 
      analysis of the molecular mechanisms and key features of pyroptosis. We also 
      outline the current research progress on various aspects, including synovial 
      tissue, articular cartilage, extracellular matrix (ECM), and subchondral bone, 
      with a focus on pyroptosis. The aim is to provide theoretical references for the 
      effective management of OA.
CI  - (c) 2024 Chen et al.
FAU - Chen, Yeping
AU  - Chen Y
AUID- ORCID: 0009-0002-8499-3734
AD  - Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, People's Republic of China.
FAU - Zeng, Daofu
AU  - Zeng D
AD  - Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, People's Republic of China.
FAU - Wei, Guizheng
AU  - Wei G
AUID- ORCID: 0009-0006-0479-5076
AD  - Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, People's Republic of China.
FAU - Liao, Zhidong
AU  - Liao Z
AD  - Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, People's Republic of China.
AD  - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource 
      Development and Application Co-Constructed by the Province and Ministry, Guangxi 
      Medical University, Nanning, Guangxi, People's Republic of China.
FAU - Liang, Rongyuan
AU  - Liang R
AD  - Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, People's Republic of China.
FAU - Huang, Xiajie
AU  - Huang X
AD  - Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, People's Republic of China.
AD  - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource 
      Development and Application Co-Constructed by the Province and Ministry, Guangxi 
      Medical University, Nanning, Guangxi, People's Republic of China.
FAU - Lu, William W
AU  - Lu WW
AUID- ORCID: 0000-0002-5780-2886
AD  - Department of Orthopedics and Traumatology, the University of Hong Kong, Hong 
      Kong, People's Republic of China.
FAU - Chen, Yan
AU  - Chen Y
AD  - Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi 
      Medical University, Nanning, Guangxi, People's Republic of China.
AD  - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource 
      Development and Application Co-Constructed by the Province and Ministry, Guangxi 
      Medical University, Nanning, Guangxi, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240208
PL  - New Zealand
TA  - J Inflamm Res
JT  - Journal of inflammation research
JID - 101512684
PMC - PMC10860821
OTO - NOTNLM
OT  - GSDMD
OT  - caspases-1/4/5/11
OT  - chondrocytes
OT  - osteoarthritis
OT  - pyroptosis
OT  - synovium
COIS- The authors declare that the authors involved in the research had absolutely no 
      commercial or financial relationships that could in any way be seen as a 
      potential conflict of interest.
EDAT- 2024/02/13 06:45
MHDA- 2024/02/13 06:46
PMCR- 2024/02/08
CRDT- 2024/02/13 03:49
PHST- 2023/11/06 00:00 [received]
PHST- 2024/01/20 00:00 [accepted]
PHST- 2024/02/13 06:46 [medline]
PHST- 2024/02/13 06:45 [pubmed]
PHST- 2024/02/13 03:49 [entrez]
PHST- 2024/02/08 00:00 [pmc-release]
AID - 445573 [pii]
AID - 10.2147/JIR.S445573 [doi]
PST - epublish
SO  - J Inflamm Res. 2024 Feb 8;17:791-803. doi: 10.2147/JIR.S445573. eCollection 2024.