PMID- 38348768
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240321
IS  - 1099-0844 (Electronic)
IS  - 0263-6484 (Linking)
VI  - 42
IP  - 2
DP  - 2024 Mar
TI  - Decoding the synergistic potential of MAZ-51 and zingerone as therapy for 
      melanoma treatment in alignment with sustainable development goals.
PG  - e3950
LID - 10.1002/cbf.3950 [doi]
AB  - Melanoma, an invasive class of skin cancer, originates from mutations in 
      melanocytes, the pigment-producing cells. Globally, approximately 132,000 new 
      cases are reported each year, and in South Africa, the incidence stands at 2.7 
      per 100,000 people, signifying a worrisome surge in melanoma rates. Therefore, 
      there is a need to explore treatment modalities that will target melanoma's 
      signalling pathways. Melanoma metastasis is aided by ligand activity of 
      transforming growth factor-beta 1 (TGF-beta1), vascular endothelial growth factor-C 
      (VEGF-C) and C-X-C chemokine ligand 12 (CXCL12) which bind to their receptors and 
      promote tumour cell survival, lymphangiogenesis and chemotaxis. 
      (3-(4-dimethylaminonaphthelen-1-ylmethylene)-1,3-dihydroindol-2-one) MAZ-51 is an 
      indolinone-based molecule that inhibits VEGF-C induced phosphorylation of 
      vascular endothelial growth factor receptor 3 (VEGFR-3). Despite the successful 
      use of conventional cancer therapies, patients endure adverse side effects and 
      cancer drug resistance. Moreover, conventional therapies are toxic to the 
      environment and caregivers. The use of medicinal plants and their phytochemical 
      constituents in cancer treatment strategies has become more widespread because of 
      the rise in drug resistance and the development of unfavourable side effects. 
      Zingerone, a phytochemical derived from ginger exhibits various pharmacological 
      properties positioning it as a promising candidate for cancer treatment. This 
      review provides an overview of melanoma biology and the intracellular signalling 
      pathways promoting cell survival, proliferation and adhesion. There is a need to 
      align health and environmental objectives within sustainable development goals 3 
      (good health and well-being), 13 (climate action) and 15 (life on land) to 
      promote early detection of skin cancer, enhance sun-safe practices, mitigation of 
      environmental factors and advancing the preservation of biodiversity, including 
      medicinal plants. Thus, this review discusses the impact of cytostatic cancer 
      drugs on patients and the environment and examines the potential use of 
      phytochemicals as adjuvant therapy.
CI  - (c) 2024 The Authors. Cell Biochemistry and Function published by John Wiley & Sons 
      Ltd.
FAU - Letsoalo, Kganya
AU  - Letsoalo K
AUID- ORCID: 0000-0003-1679-5293
AD  - Department of Physiology, University of Pretoria, Pretoria, South Africa.
FAU - Nortje, Evangeline
AU  - Nortje E
AUID- ORCID: 0000-0002-0042-4466
AD  - Department of Physiology, University of Pretoria, Pretoria, South Africa.
FAU - Patrick, Sean
AU  - Patrick S
AUID- ORCID: 0000-0002-0364-0068
AD  - Environmental Chemical Pollution and Health Research Unit, University of 
      Pretoria, Pretoria, South Africa.
FAU - Nyakudya, Trevor
AU  - Nyakudya T
AUID- ORCID: 0000-0003-1872-9257
AD  - Department of Physiology, University of Pretoria, Pretoria, South Africa.
FAU - Hlophe, Yvette
AU  - Hlophe Y
AUID- ORCID: 0000-0002-3112-2436
AD  - Department of Physiology, University of Pretoria, Pretoria, South Africa.
LA  - eng
GR  - N1F580A1F685/National Research Foundation/
GR  - University of Pretoria Postgraduate Funding Scheme/
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cell Biochem Funct
JT  - Cell biochemistry and function
JID - 8305874
RN  - 0 (Vascular Endothelial Growth Factor C)
RN  - 4MMW850892 (zingerone)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Ligands)
RN  - 0 (Phytochemicals)
RN  - 6JKA7MAH9C (Guaiacol)
SB  - IM
MH  - Humans
MH  - *Melanoma/metabolism
MH  - Vascular Endothelial Growth Factor C/metabolism
MH  - Vascular Endothelial Growth Factor A
MH  - Ligands
MH  - Sustainable Development
MH  - *Skin Neoplasms/drug therapy/pathology
MH  - Phytochemicals
MH  - Guaiacol/*analogs & derivatives
OTO - NOTNLM
OT  - MAZ-51
OT  - chemotherapeutics
OT  - melanoma
OT  - phytochemicals
OT  - sustainable development goals
OT  - zingerone
EDAT- 2024/02/13 06:46
MHDA- 2024/02/14 12:42
CRDT- 2024/02/13 05:38
PHST- 2023/12/28 00:00 [revised]
PHST- 2023/09/25 00:00 [received]
PHST- 2024/01/29 00:00 [accepted]
PHST- 2024/02/14 12:42 [medline]
PHST- 2024/02/13 06:46 [pubmed]
PHST- 2024/02/13 05:38 [entrez]
AID - 10.1002/cbf.3950 [doi]
PST - ppublish
SO  - Cell Biochem Funct. 2024 Mar;42(2):e3950. doi: 10.1002/cbf.3950.