PMID- 38350951
OWN - NLM
STAT- MEDLINE
DCOM- 20240215
LR  - 20240313
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 23
IP  - 1
DP  - 2024 Feb 13
TI  - DNA methylation risk score for type 2 diabetes is associated with gestational 
      diabetes.
PG  - 68
LID - 10.1186/s12933-024-02151-z [doi]
LID - 68
AB  - BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus 
      (T2DM) share many pathophysiological factors including genetics, but whether 
      epigenetic marks are shared is unknown. We aimed to test whether a DNA 
      methylation risk score (MRS) for T2DM was associated with GDM across ancestry and 
      GDM criteria. METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) 
      and EPIDG (n = 32), DNA methylation in peripheral blood leukocytes was measured 
      at a gestational age of 28 +/- 2. We constructed an MRS in EPIPREG and EPIDG based 
      on CpG hits from a published epigenome-wide association study (EWAS) of T2DM. 
      RESULTS: With mixed models logistic regression of EPIPREG and EPIDG, MRS for T2DM 
      was associated with GDM: odd ratio (OR)[95% CI]: 1.3 [1.1-1.8], P = 0.002 for the 
      unadjusted model, and 1.4 [1.1-1.7], P = 0.00014 for a model adjusted by age, 
      pre-pregnant BMI, family history of diabetes and smoking status. Also, we found 6 
      CpGs through a meta-analysis (cg14020176, cg22650271, cg14870271, cg27243685, 
      cg06378491, cg25130381) associated with GDM, and some of their methylation 
      quantitative loci (mQTLs) were related to T2DM and GDM. CONCLUSION: For the first 
      time, we show that DNA methylation marks for T2DM are also associated with GDM, 
      suggesting shared epigenetic mechanisms between GDM and T2DM.
CI  - (c) 2024. The Author(s).
FAU - Linares-Pineda, Teresa M
AU  - Linares-Pineda TM
AD  - Department of Endocrinology and Nutrition, Instituto de Investigacion Biomedica 
      Malaga (IBIMA)- Plataforma Bionand, University Hospital Virgen de la Victoria, 
      Malaga, Spain.
AD  - Department of Biochemistry and Molecular Biology 2, University of Granada, 
      Granada, Spain.
AD  - Centre for Biomedical Research Network on Obesity Physiopathology and Nutrition 
      (CIBEROBN), Madrid, Spain.
FAU - Fragoso-Bargas, Nicolas
AU  - Fragoso-Bargas N
AD  - Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo 
      University Hospital, Oslo, 0424, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, 
      University of Bergen, Bergen, Norway.
FAU - Picon, Maria Jose
AU  - Picon MJ
AD  - Department of Endocrinology and Nutrition, Instituto de Investigacion Biomedica 
      Malaga (IBIMA)- Plataforma Bionand, University Hospital Virgen de la Victoria, 
      Malaga, Spain.
FAU - Molina-Vega, Maria
AU  - Molina-Vega M
AD  - Department of Endocrinology and Nutrition, Instituto de Investigacion Biomedica 
      Malaga (IBIMA)- Plataforma Bionand, University Hospital Virgen de la Victoria, 
      Malaga, Spain.
FAU - Jenum, Anne Karen
AU  - Jenum AK
AD  - General Practice Research Unit (AFE), Department of General Practice, Institute 
      of Health and Society, University of Oslo, Oslo, Norway.
FAU - Sletner, Line
AU  - Sletner L
AD  - Department of Pediatric and Adolescents Medicine, Akershus University Hospital, 
      Lorenskog, Norway.
FAU - Lee-Odegard, Sindre
AU  - Lee-Odegard S
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Opsahl, Julia O
AU  - Opsahl JO
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Haukeland University Hospital, Bergen, Norway.
FAU - Moen, Gunn-Helen
AU  - Moen GH
AD  - Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo 
      University Hospital, Oslo, 0424, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
AD  - Institute of Molecular Bioscience, The University of Queensland, Brisbane, 
      Australia.
AD  - K. G Jebsen Center for Genetic Epidemiology, Department of Public Health and 
      Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
AD  - Population Health Science, Bristol Medical School, University of Bristol, 
      Bristol, UK.
AD  - Frazer Institute, The University of Queensland, Woolloongabba, QLD, 4102, 
      Australia.
FAU - Qvigstad, Elisabeth
AU  - Qvigstad E
AD  - Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo 
      University Hospital, Oslo, 0424, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Prasad, Rashmi B
AU  - Prasad RB
AD  - Lund University Diabetes Centre, Malmo, Sweden.
AD  - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 
      Helsinki, Finland.
FAU - Birkeland, Kare I
AU  - Birkeland KI
AD  - Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo 
      University Hospital, Oslo, 0424, Norway.
AD  - Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, 
      Norway.
FAU - Morcillo, Sonsoles
AU  - Morcillo S
AD  - Department of Endocrinology and Nutrition, Instituto de Investigacion Biomedica 
      Malaga (IBIMA)- Plataforma Bionand, University Hospital Virgen de la Victoria, 
      Malaga, Spain.
AD  - Centre for Biomedical Research Network on Obesity Physiopathology and Nutrition 
      (CIBEROBN), Madrid, Spain.
FAU - Sommer, Christine
AU  - Sommer C
AD  - Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo 
      University Hospital, Oslo, 0424, Norway. christine.sommer@medisin.uio.no.
LA  - eng
GR  - FI19/00178/Instituto de Salud Carlos III/
GR  - PI18/01175/Instituto de Salud Carlos III/
GR  - 2019092/Helse Sor-Ost RHF/
GR  - PI-0283-2018/Servicio Andaluz de Salud/
GR  - PI-0419-2019/Servicio Andaluz de Salud/
GR  - RC-0008-2021/Servicio Andaluz de Salud/
GR  - 271555/F20/Norges Forskningsrad/
GR  - 325640/Norges Forskningsrad/
GR  - DE220101226/Australian Research Council/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20240213
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *Diabetes, Gestational/diagnosis/epidemiology/genetics
MH  - DNA Methylation
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology/genetics
MH  - Epigenesis, Genetic
MH  - Risk Factors
PMC - PMC10865541
OTO - NOTNLM
OT  - DNA epigenetics
OT  - Epigenetics
OT  - Gestational diabetes
OT  - Methylation risk score
OT  - Type 2 diabetes
COIS- The authors declare there is no conflict of interest.
EDAT- 2024/02/14 00:44
MHDA- 2024/02/15 06:43
PMCR- 2024/02/13
CRDT- 2024/02/13 23:37
PHST- 2023/12/14 00:00 [received]
PHST- 2024/02/02 00:00 [accepted]
PHST- 2024/02/15 06:43 [medline]
PHST- 2024/02/14 00:44 [pubmed]
PHST- 2024/02/13 23:37 [entrez]
PHST- 2024/02/13 00:00 [pmc-release]
AID - 10.1186/s12933-024-02151-z [pii]
AID - 2151 [pii]
AID - 10.1186/s12933-024-02151-z [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2024 Feb 13;23(1):68. doi: 10.1186/s12933-024-02151-z.