PMID- 38351959
OWN - NLM
STAT- MEDLINE
DCOM- 20240215
LR  - 20240215
IS  - 2296-2565 (Electronic)
IS  - 2296-2565 (Linking)
VI  - 12
DP  - 2024
TI  - Exposure to volatile organic compounds is a risk factor for diabetes retinopathy: 
      a cross-sectional study.
PG  - 1347671
LID - 10.3389/fpubh.2024.1347671 [doi]
LID - 1347671
AB  - INTRODUCTION: A few past experimental studies have indicated that exposure to 
      volatile organic compounds (VOCs) might be a potential risk factor for diabetes 
      retinopathy (DR). However, these findings lack substantial support from extensive 
      epidemiological research. This large-scale cross-sectional study aimed to examine 
      whether exposure to low levels of VOCs in the general population is associated 
      with diabetes mellitus (DM) and DR. METHODS: The analytical data was from the 
      National Health and Nutrition Examination Survey (NHANES) dataset (2011-2018). To 
      minimize the potential impact of gender and age on the findings, propensity score 
      matching was utilized to align the data selection. Relationships between blood 
      VOCs and DM and DR were assessed in a sample of 2,932 adults using the logistic 
      regression models. Additionally, Bayesian kernel machine regression (BKMR) models 
      and Weighted Quantile Sum (WQS) were conducted for mixture exposure analysis. 
      RESULTS: The result shows VOCs were positive associated with DM and DR in US 
      adults, as assessed by WQS model, and the calculated odd ratios (ORs) [95% 
      confidence interval (C.I)] were 53.91(34.11 ~ 85.22) and 7.38(3.65 ~ 14.92), 
      respectively. Among the components of VOCs, 1,2-Dibromoethane, Carbon 
      Tetrachloride and 2,5-Dimethylfuran were positive related with the DR, and ORs 
      (95%C.I) were 2.91(2.29 ~ 3.70), 2.86(2.25 ~ 3.65) and 2.19(1.79 ~ 2.94), 
      respectively. BKMR model shows that there was a dose-response relationship 
      between combined VOCs and DR, although the relationship was non-linearly. 
      CONCLUSION: This study suggested that exposure to VOCs may increase the risk of 
      DR, which had important public health implications.
CI  - Copyright (c) 2024 Wang, Chen, Peng, Wang, Ding, Li and Xu.
FAU - Wang, Zhi
AU  - Wang Z
AD  - Department of Endocrinology, The Second People's Hospital of Lianyungang, 
      Lianyungang, China.
FAU - Chen, Dongjun
AU  - Chen D
AD  - Department of Cardiac Function Examine, The Second People's Hospital of 
      Lianyungang, Lianyungang, China.
FAU - Peng, Lingling
AU  - Peng L
AD  - Department of Endocrinology, The Second People's Hospital of Lianyungang, 
      Lianyungang, China.
FAU - Wang, Xian
AU  - Wang X
AD  - Department of Ultrasonography, The Second People's Hospital of Lianyungang, 
      Lianyungang, China.
FAU - Ding, Qun
AU  - Ding Q
AD  - Department of Endocrinology, The Second People's Hospital of Lianyungang, 
      Lianyungang, China.
FAU - Li, Liang
AU  - Li L
AD  - Department of Ultrasonography, The Second People's Hospital of Lianyungang, 
      Lianyungang, China.
FAU - Xu, Tongdao
AU  - Xu T
AD  - Department of Endocrinology, The Second People's Hospital of Lianyungang, 
      Lianyungang, China.
LA  - eng
PT  - Journal Article
DEP - 20240130
PL  - Switzerland
TA  - Front Public Health
JT  - Frontiers in public health
JID - 101616579
RN  - 0 (Volatile Organic Compounds)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - *Volatile Organic Compounds/adverse effects
MH  - Environmental Exposure/adverse effects
MH  - Bayes Theorem
MH  - *Diabetic Retinopathy/epidemiology/etiology
MH  - Risk Factors
MH  - *Diabetes Mellitus
PMC - PMC10861660
OTO - NOTNLM
OT  - NHANES
OT  - diabetes mellitus
OT  - diabetic retinopathy
OT  - epidemiology
OT  - volatile organic compounds
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2024/02/14 06:44
MHDA- 2024/02/15 06:43
PMCR- 2024/01/30
CRDT- 2024/02/14 03:45
PHST- 2023/12/01 00:00 [received]
PHST- 2024/01/17 00:00 [accepted]
PHST- 2024/02/15 06:43 [medline]
PHST- 2024/02/14 06:44 [pubmed]
PHST- 2024/02/14 03:45 [entrez]
PHST- 2024/01/30 00:00 [pmc-release]
AID - 10.3389/fpubh.2024.1347671 [doi]
PST - epublish
SO  - Front Public Health. 2024 Jan 30;12:1347671. doi: 10.3389/fpubh.2024.1347671. 
      eCollection 2024.