PMID- 38352643
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240215
IS  - 2213-5979 (Print)
IS  - 2213-5979 (Electronic)
IS  - 2213-5979 (Linking)
VI  - 36
DP  - 2024 Apr
TI  - Real-time dual-modal photoacoustic and fluorescence small animal imaging.
PG  - 100593
LID - 10.1016/j.pacs.2024.100593 [doi]
LID - 100593
AB  - By combining optical absorption contrast and acoustic resolution, photoacoustic 
      imaging (PAI) has broken the barrier in depth for high-resolution optical 
      imaging. Meanwhile, Fluorescence imaging (FLI), owing to advantages of high 
      sensitivity and high specificity with abundant fluorescence agents and proteins, 
      has always been playing a key role in live animal studies. Based on different 
      optical contrast mechanisms, PAI and FLI can provide important complementary 
      information to each other. In this work, we uniquely designed a 
      Photoacoustic-Fluorescence (PA-FL) imaging system that provides real-time dual 
      modality imaging, in which a half-ring ultrasonic array is employed for high 
      quality PA tomography and a specially designed optical window allows simultaneous 
      whole-body fluorescence imaging. The performance of this dual modality system was 
      demonstrated in live animal studies, including real-time monitoring of perfusion 
      and metabolic processes of fluorescent dyes. Our study indicates that the PA-FL 
      imaging system has unique potential for live small animal research.
CI  - (c) 2024 The Authors.
FAU - Sun, Yu
AU  - Sun Y
AD  - Department of Biomedical Engineering, School of Future Technology, Peking 
      University, Beijing 100871, China.
FAU - Wang, Yibing
AU  - Wang Y
AD  - Department of Biomedical Engineering, School of Future Technology, Peking 
      University, Beijing 100871, China.
FAU - Li, Wenzhao
AU  - Li W
AD  - Department of Biomedical Engineering, School of Future Technology, Peking 
      University, Beijing 100871, China.
FAU - Li, Changhui
AU  - Li C
AD  - Department of Biomedical Engineering, School of Future Technology, Peking 
      University, Beijing 100871, China.
AD  - National Biomedical Imaging Center, Peking University, Beijing 100871, China.
LA  - eng
PT  - Journal Article
DEP - 20240202
PL  - Germany
TA  - Photoacoustics
JT  - Photoacoustics
JID - 101622604
PMC - PMC10862394
OTO - NOTNLM
OT  - Fluorescence imaging
OT  - Multimodal imaging
OT  - Photoacoustic imaging
OT  - Real time
OT  - Small animal imaging
COIS- We declare that we have no financial and personal relationships with other people 
      or organizations that can inappropriately influence our work. there is no 
      professional or other personal interest of any nature or kind in any product, 
      service and/or company that could be construed as influencing the position 
      presented in, or the review of, the manuscript entitled "Real-time dual-modal 
      photoacoustic and fluorescence small animal imaging system".
EDAT- 2024/02/14 06:43
MHDA- 2024/02/14 06:44
PMCR- 2024/02/02
CRDT- 2024/02/14 03:55
PHST- 2023/10/31 00:00 [received]
PHST- 2024/01/30 00:00 [revised]
PHST- 2024/01/30 00:00 [accepted]
PHST- 2024/02/14 06:44 [medline]
PHST- 2024/02/14 06:43 [pubmed]
PHST- 2024/02/14 03:55 [entrez]
PHST- 2024/02/02 00:00 [pmc-release]
AID - S2213-5979(24)00010-7 [pii]
AID - 100593 [pii]
AID - 10.1016/j.pacs.2024.100593 [doi]
PST - epublish
SO  - Photoacoustics. 2024 Feb 2;36:100593. doi: 10.1016/j.pacs.2024.100593. 
      eCollection 2024 Apr.