PMID- 38353547
OWN - NLM
STAT- Publisher
LR  - 20240214
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
DP  - 2024 Feb 14
TI  - Fractional Flow Reserve and Angiography Guided Complete Revascularization in 
      Primary Percutaneous Coronary Intervention: A Systematic Review and Network 
      Meta-Analysis.
PG  - 33197241232441
LID - 10.1177/00033197241232441 [doi]
AB  - Using a network meta-analysis, this study compared fractional flow reserve (FFR) 
      guided with angiography-guided revascularization of non-culprit lesions in ST 
      elevation myocardial infarction (STEMI). We also assessed if early complete 
      revascularization is superior to delayed revascularization. We conducted a 
      network meta-analysis using Net Meta XL of trials of STEMI patients with 
      multivessel disease and compared revascularization strategies. The primary 
      outcomes of interest were rate of revascularization, myocardial infarction, and 
      all-cause mortality. Ten studies were included in our analysis comprising 7981 
      patients with 4484 patients undergoing complete revascularization and 3497 
      patients with culprit-only revascularization. There was no significant reduction 
      in all-cause death, myocardial infarction, or revascularization using FFR 
      guidance. There was significant reduction in repeat revascularization with 
      complete revascularization irrespective of timing of percutaneous coronary 
      intervention (PCI) compared with the culprit-only group. There was an overall 
      trend favoring earlier revascularization. For patients with multivessel disease 
      presenting with ST-elevation MI, complete revascularization significantly reduces 
      repeat revascularization compared with culprit-only treatment. FFR guidance is 
      non-superior to angiography-guided revascularization. Furthermore, there was 
      significant reduction in repeat revascularization irrespective of timing of PCI 
      to non-culprit vessels.
FAU - Hyasat, Kais
AU  - Hyasat K
AUID- ORCID: 0000-0001-6947-7083
AD  - Department of Cardiology, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia. 
      RINGGOLD: 1512
AD  - Department of Cardiology, Liverpool Hospital, Liverpool, NSW, Australia.
AD  - University of New South Wales, Sydney, NSW, Australia.
FAU - Hasche, Edmund
AU  - Hasche E
AD  - Department of Cardiology, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia. 
      RINGGOLD: 1512
FAU - Almafragy, Hamid
AU  - Almafragy H
AD  - Department of Cardiology, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia. 
      RINGGOLD: 1512
FAU - Chiha, Joseph
AU  - Chiha J
AD  - Department of Cardiology, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia. 
      RINGGOLD: 1512
FAU - Asrress, Kaleab
AU  - Asrress K
AD  - Department of Cardiology, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia. 
      RINGGOLD: 1512
AD  - Department of Cardiology, Liverpool Hospital, Liverpool, NSW, Australia.
AD  - University of New South Wales, Sydney, NSW, Australia.
FAU - Liou, Kevin
AU  - Liou K
AD  - Department of Cardiology, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia. 
      RINGGOLD: 1512
AD  - University of New South Wales, Sydney, NSW, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240214
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
SB  - IM
OTO - NOTNLM
OT  - complete revascularization
OT  - fractional flow reserve
OT  - percutaneous coronary intervention
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2024/02/14 12:48
MHDA- 2024/02/14 12:48
CRDT- 2024/02/14 09:04
PHST- 2024/02/14 12:48 [medline]
PHST- 2024/02/14 12:48 [pubmed]
PHST- 2024/02/14 09:04 [entrez]
AID - 10.1177/00033197241232441 [doi]
PST - aheadofprint
SO  - Angiology. 2024 Feb 14:33197241232441. doi: 10.1177/00033197241232441.