PMID- 3835470
OWN - NLM
STAT- MEDLINE
DCOM- 19860714
LR  - 20031114
IS  - 0275-1380 (Print)
IS  - 0275-1380 (Linking)
VI  - 7
IP  - 6
DP  - 1985 Nov-Dec
TI  - Conceptual and procedural considerations for developmental assessment of learning 
      and memory (dys)function following neurotoxicant exposure.
PG  - 703-8
AB  - Symptoms of memory impairment are often reported following neurotoxicant 
      exposure. Untoward effects on the developing organism, potentially reflected as 
      later learning disabilities and memory problems, deserve critical evaluation. 
      Animal models providing rigorous experimental control are extremely important in 
      this context. The psychological literature offers a variety of tasks and 
      procedures for use across many developmental ages. Most recent progress has 
      demonstrated evidence of associative capacity in infrahumans as early as birth, 
      and under specific conditions even prenatally. Common to all assessments of 
      learning and memory capabilities, however, is the requisite that these processes 
      be inferred from overt behavior. This requirement confers the responsibility of 
      differentiating alterations of an associative nature from those of a 
      nonassociative nature (e.g., motivation, attention, perception, sensory 
      adaptation, fatigue, activity, and reactivity, etc.). When across age comparisons 
      are also of interest, additional attention must be paid to potential differences 
      in available sensory processes, response repertoire, and ecologically relevant 
      contextual determinants (e.g., ambient temperature, presence of familiar odors or 
      conspecifics), particularly with preweanling and neonatal animals. Specific 
      guidelines are offered for the criteria and implementation of controls typically 
      necessary to provide a convincing demonstration of an associative impairment.
FAU - Mactutus, C F
AU  - Mactutus CF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurobehav Toxicol Teratol
JT  - Neurobehavioral toxicology and teratology
JID - 8104162
SB  - IM
MH  - Animals
MH  - Cognition/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Learning/*drug effects
MH  - Memory/*drug effects
MH  - Nervous System Diseases/*chemically induced/psychology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Research Design
EDAT- 1985/11/01 00:00
MHDA- 1985/11/01 00:01
CRDT- 1985/11/01 00:00
PHST- 1985/11/01 00:00 [pubmed]
PHST- 1985/11/01 00:01 [medline]
PHST- 1985/11/01 00:00 [entrez]
PST - ppublish
SO  - Neurobehav Toxicol Teratol. 1985 Nov-Dec;7(6):703-8.