PMID- 38355878
OWN - NLM
STAT- MEDLINE
DCOM- 20240216
LR  - 20240216
IS  - 1097-0231 (Electronic)
IS  - 0951-4198 (Linking)
VI  - 38
IP  - 5
DP  - 2024 Mar 15
TI  - A fast method for the determination of personal care product chemicals in human 
      urine using dispersive liquid-liquid extraction and ultra high-performance liquid 
      chromatography-tandem mass spectrometry.
PG  - e9684
LID - 10.1002/rcm.9684 [doi]
AB  - RATIONALE: Personal care product chemicals (PCPCs) are the chemicals used in 
      personal care products. Many of them are endocrine disruptors and have potential 
      adverse effects on humans. The concentrations of PCPCs in urine are the main 
      biomarker for assessing human exposure. METHODS: A method was developed for the 
      simultaneous determination of 14 PCPCs in human urine using dispersive 
      liquid-liquid extraction combined with ultra high-performance liquid 
      chromatography-tandem mass spectrometry (UHPLC-MS/MS). RESULTS: Compared with 
      liquid-liquid extraction, this method had the advantages of time efficiency, 
      sensitivity, and limited organic solvent consumption. It produced good linearity 
      (0.9965-0.9996), limits of detection (2.82-36.36 pg mL(-1) ), limits of 
      quantitation (9.39-121.08 pg mL(-1) ), matrix effect (-0.90%-2.55%), intra-day 
      precision (relative standard deviations [RSDs] <15%), and inter-day precision 
      (RSDs <19.9%). The method had satisfactory relative recovery at three 
      concentration levels. CONCLUSIONS: A rapid method was developed for the 
      simultaneous quantification of 14 PCPCs in human urine. The practicability of the 
      method was verified with 21 urine from university students. It is expected that 
      this method will provide a powerful reference for the assessment of exposure to 
      PCPCs in large populations.
CI  - (c) 2024 John Wiley & Sons Ltd.
FAU - Zheng, Yawen
AU  - Zheng Y
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
FAU - Liu, Yarui
AU  - Liu Y
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
FAU - Zhang, Zining
AU  - Zhang Z
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
FAU - Hua, Liting
AU  - Hua L
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
FAU - Fang, Jing
AU  - Fang J
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
FAU - Wang, Lei
AU  - Wang L
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
FAU - Zhao, Hongzhi
AU  - Zhao H
AD  - Ministry of Education Key Laboratory of Pollution Processes and Environmental 
      Criteria, College of Environmental Science and Engineering, Nankai University, 
      Tianjin, China.
LA  - eng
GR  - 2022YFC3703203/National Key Research and Development Program of China/
GR  - 42177412/National Natural Science Foundation of China/
GR  - T2017002/Ministry of Education of the People's Republic of China/
PT  - Journal Article
PL  - England
TA  - Rapid Commun Mass Spectrom
JT  - Rapid communications in mass spectrometry : RCM
JID - 8802365
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Chromatography, High Pressure Liquid/methods
MH  - *Tandem Mass Spectrometry/methods
MH  - Liquid-Liquid Extraction
MH  - *Endocrine Disruptors/analysis
MH  - Biomarkers/analysis
MH  - Solid Phase Extraction/methods
EDAT- 2024/02/15 00:42
MHDA- 2024/02/16 06:42
CRDT- 2024/02/14 23:58
PHST- 2023/11/26 00:00 [revised]
PHST- 2023/10/23 00:00 [received]
PHST- 2023/11/27 00:00 [accepted]
PHST- 2024/02/16 06:42 [medline]
PHST- 2024/02/15 00:42 [pubmed]
PHST- 2024/02/14 23:58 [entrez]
AID - 10.1002/rcm.9684 [doi]
PST - ppublish
SO  - Rapid Commun Mass Spectrom. 2024 Mar 15;38(5):e9684. doi: 10.1002/rcm.9684.