PMID- 38356293 OWN - NLM STAT- MEDLINE DCOM- 20240410 LR - 20240418 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) VI - 78 IP - 4 DP - 2024 Apr TI - Humoral immune response and safety of SARS-CoV-2 vaccination in very early onset inflammatory bowel disease. PG - 871-877 LID - 10.1002/jpn3.12142 [doi] AB - Children with very early onset inflammatory bowel disease (VEO-IBD) may respond differently to coronavirus disease 2019 (COVID-19) immunization compared to healthy children or other patients with IBD. We recruited children with VEO-IBD <6 years of age and younger following receipt of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. Demographics, IBD characteristics, medication use, adverse events (AEs) and IBD exacerbations were collected. Blood draws (optional) were obtained for measurement of antireceptor binding domain (RBD) IgG antibodies following vaccination. Of 41 participants, none required emergency department visit or hospitalization due to AE, and only one experienced IBD exacerbation. Detectable antibody was present in 19/19 participants who provided blood sample; 6/7 participants (86%) had durable humoral response 12 months postvaccination. Children with VEO-IBD experience robust humoral immune response to COVID-19 immunization. Severe AEs were rare. These findings provide reassurance that children with VEO-IBD respond well and safely to SARS-CoV-2 vaccination. CI - (c) 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Kastl, Arthur J AU - Kastl AJ AD - Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FAU - Weaver, Kimberly N AU - Weaver KN AD - Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Zhang, Xian AU - Zhang X AD - Department of Pediatrics, Division of Pediatric Gastroenterology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Strople, Jennifer A AU - Strople JA AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. FAU - Adler, Jeremy AU - Adler J AD - Susan B. Meister Child Health Evaluation and Research Center and Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA. FAU - Kelsen, Judith R AU - Kelsen JR AD - Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FAU - Dubinsky, Marla C AU - Dubinsky MC AD - Department of Pediatrics, Susan and Leonard Feinstein IBD Center, Icahn School of Medicine, Mount Sinai, New York, USA. FAU - Bousvaros, Athos AU - Bousvaros A AD - Children's Hospital, Boston, Massachusetts, USA. FAU - Watkins, Runa AU - Watkins R AD - Division of Pediatric Gastroenterology and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA. FAU - Dai, Colin AU - Dai C AD - Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Cross, Raymond K AU - Cross RK AD - Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland, USA. FAU - Higgins, Peter D R AU - Higgins PDR AD - Department of Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA. FAU - Ungaro, Ryan AU - Ungaro R AD - Department of Medicine, Susan and Leonard Feinstein IBD Center, Icahn School of Medicine, Mount Sinai, New York, USA. FAU - Bewtra, Meenakshi AU - Bewtra M AD - Department of Medicine, Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Bellaguarda, Emanuelle A AU - Bellaguarda EA AD - Division of Gastroenterology and Hepatology, Northwestern University, Chicago, Illinois, USA. FAU - Farraye, Francis A AU - Farraye FA AD - Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA. FAU - Chun, Kelly AU - Chun K AD - Esoterix Specialty Laboratory, LabCorp, Calabasas, California, USA. FAU - Zikry, Michael AU - Zikry M AD - Esoterix Specialty Laboratory, LabCorp, Calabasas, California, USA. FAU - Bastidas, Monique AU - Bastidas M AD - Esoterix Specialty Laboratory, LabCorp, Calabasas, California, USA. FAU - Boccieri, Margie E AU - Boccieri ME AD - Department of Pediatrics, Division of Pediatric Gastroenterology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Firestine, Ann AU - Firestine A AD - Department of Pediatrics, Division of Pediatric Gastroenterology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Long, Millie D AU - Long MD AD - Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Kappelman, Michael D AU - Kappelman MD AD - Department of Pediatrics, Division of Pediatric Gastroenterology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. LA - eng GR - R01 DK127044/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20240214 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - 0 (COVID-19 Vaccines) RN - 0 (Immunoglobulin G) RN - 0 (Antibodies, Viral) SB - IM MH - Child MH - Humans MH - Immunity, Humoral MH - COVID-19 Vaccines/adverse effects MH - SARS-CoV-2 MH - *COVID-19/prevention & control MH - Vaccination/adverse effects MH - Immunoglobulin G MH - *Inflammatory Bowel Diseases MH - Antibodies, Viral OTO - NOTNLM OT - COVID-19 OT - Moderna OT - Pfizer OT - antibody OT - vaccine EDAT- 2024/02/15 06:43 MHDA- 2024/04/10 06:42 CRDT- 2024/02/15 02:34 PHST- 2023/11/09 00:00 [revised] PHST- 2023/09/12 00:00 [received] PHST- 2023/11/09 00:00 [accepted] PHST- 2024/04/10 06:42 [medline] PHST- 2024/02/15 06:43 [pubmed] PHST- 2024/02/15 02:34 [entrez] AID - 10.1002/jpn3.12142 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2024 Apr;78(4):871-877. doi: 10.1002/jpn3.12142. Epub 2024 Feb 14.