PMID- 38356700
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240306
IS  - 1837-9664 (Print)
IS  - 1837-9664 (Electronic)
IS  - 1837-9664 (Linking)
VI  - 15
IP  - 5
DP  - 2024
TI  - Salmonella-induced inhibition of beta3-adrenoceptor expression in tumors and reduces 
      tumor metastasis.
PG  - 1203-1212
LID - 10.7150/jca.92024 [doi]
AB  - The beta3-adrenoceptor is a protein responsible for regulating the body's response 
      to the neurotransmitter adrenaline and the hormone norepinephrine. It is critical 
      in various physiological processes, including metabolism, thermogenesis, and 
      cardiovascular function. Recently, researchers have discovered that the 
      beta3-adrenoceptor is also implicated in tumor progression and metastasis. 
      Infections caused by Salmonella can lead to gastroenteritis; however, 
      intriguingly, Salmonella is associated with tumor inhibition. In this study, 
      Salmonella treatment resulted in the downregulation of beta3-adrenoceptor expression 
      and a decrease in the phosphorylation of the Protein Kinase-B (AKT)/Mammalian 
      Target of Rapamycin (mTOR) pathway, as observed through immunoblotting in a 
      dose-dependent manner. Notably, Salmonella treatment significantly reduced tumor 
      cell migration, as demonstrated by wound healing and Transwell assays. Moreover, 
      tumor-bearing mice that received Salmonella-pre-treated tumor cells exhibited 
      improved survival rates compared to those injected with tumor cells without prior 
      Salmonella treatment. The observed anti-metastatic effect in this study suggests 
      that Salmonella treatment could hold promise as a potential therapeutic approach 
      to combat tumor metastasis. Further research is warranted to explore its full 
      therapeutic potential.
CI  - (c) The author(s).
FAU - Wu, Li-Hsien
AU  - Wu LH
AD  - Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 
      80424, Taiwan.
FAU - Huang, Yu-Ting
AU  - Huang YT
AD  - Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 
      80424, Taiwan.
FAU - Lin, Chung-Yu
AU  - Lin CY
AD  - Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 
      80424, Taiwan.
FAU - Lee, Che-Hsin
AU  - Lee CH
AD  - Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 
      80424, Taiwan.
AD  - School of Medicine, College of Medicine, National Sun Yat-sen University, 
      Kaohsiung 80424, Taiwan.
AD  - Department of Medical Research, China Medical University Hospital, China Medical 
      University, Taichung, Taiwan.
AD  - International PhD Program for Science, National Sun Yat-sen University, Kaohsiung 
      80424, Taiwan.
AD  - Aerosol Science Research Center, National Sun Yat-sen University, Kaohsiung 
      80424, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20240101
PL  - Australia
TA  - J Cancer
JT  - Journal of Cancer
JID - 101535920
PMC - PMC10861817
OTO - NOTNLM
OT  - Salmonella
OT  - metastasis
OT  - migration
OT  - tumor-targeting
OT  - beta3-adrenoceptor
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2024/02/15 06:43
MHDA- 2024/02/15 06:44
PMCR- 2024/01/01
CRDT- 2024/02/15 04:04
PHST- 2023/11/08 00:00 [received]
PHST- 2023/12/25 00:00 [accepted]
PHST- 2024/02/15 06:44 [medline]
PHST- 2024/02/15 06:43 [pubmed]
PHST- 2024/02/15 04:04 [entrez]
PHST- 2024/01/01 00:00 [pmc-release]
AID - jcav15p1203 [pii]
AID - 10.7150/jca.92024 [doi]
PST - epublish
SO  - J Cancer. 2024 Jan 1;15(5):1203-1212. doi: 10.7150/jca.92024. eCollection 2024.