PMID- 38357743
OWN - NLM
STAT- Publisher
LR  - 20240215
IS  - 1942-7522 (Electronic)
IS  - 0145-5613 (Linking)
DP  - 2024 Feb 15
TI  - IL-17 expression and prognosis of laryngeal squamous cell carcinoma.
PG  - 1455613241232500
LID - 10.1177/01455613241232500 [doi]
AB  - Objective: To investigate the roles of proinflammatory cytokine IL-17 in the 
      prognosis of laryngeal squamous cell carcinoma (LSCC). Methods: In all, 67 LSCC 
      patients were enrolled to evaluate the expression of IL-17, IL-23, CD8, CD31, and 
      vascular endothelial growth factor by immunohistochemical staining. Cumulative 
      survival time was determined by the Kaplan-Meier approach, and prognostic 
      variables for overall survival (OS) were identified by Cox proportional-hazards 
      models. Results: The expression of IL-17 and IL-23 was remarkably higher in LSCC 
      tissue than in adjacent normal (AN) tissue (P < .001). The Kaplan-Meier analysis 
      indicated that patients with cervical lymph node metastasis (CLNM), advanced 
      tumor node metastasis (TNM) stage, poor-differentiated grade, high microvessel 
      density (MVD) in LSCC tissues, and high IL-17 expression in AN tissues had poorer 
      OS (all P < .05). Cox regression analysis revealed that CLNM (HR = 7.246; 95% CI: 
      2.598-20.208; P < .001), high MVD in tumor tissues (HR = 4.233; 95% CI: 
      1.482-12.092; P = .007), and low CD8 expression in AN tissues (HR = 3.996; 95% 
      CI: 1.442-11.074; P = .008) were significantly associated with poorer OS in LSCC, 
      while IL-17 expression in AN tissue was not. Conclusion: High IL-17 expression in 
      AN tissues could indicate poor prognosis and may be a prognostic marker for LSCC. 
      Low CD8 expression in AN tissues may represent poor frontline antitumor immunity 
      and be associated with poor prognosis.
FAU - Li, Yun
AU  - Li Y
AD  - Department of Otolaryngology, The Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
FAU - Chen, Ming
AU  - Chen M
AUID- ORCID: 0000-0002-1066-3532
AD  - Department of Otolaryngology, The Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
DEP - 20240215
PL  - United States
TA  - Ear Nose Throat J
JT  - Ear, nose, & throat journal
JID - 7701817
SB  - IM
OTO - NOTNLM
OT  - Interleukin-17
OT  - Interleukin-23
OT  - larynx
OT  - overall survival
OT  - squamous cell carcinoma
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2024/02/15 06:43
MHDA- 2024/02/15 06:43
CRDT- 2024/02/15 04:35
PHST- 2024/02/15 06:43 [medline]
PHST- 2024/02/15 06:43 [pubmed]
PHST- 2024/02/15 04:35 [entrez]
AID - 10.1177/01455613241232500 [doi]
PST - aheadofprint
SO  - Ear Nose Throat J. 2024 Feb 15:1455613241232500. doi: 10.1177/01455613241232500.