PMID- 38357957
OWN - NLM
STAT- MEDLINE
DCOM- 20240403
LR  - 20240403
IS  - 1875-5828 (Electronic)
IS  - 1567-2050 (Linking)
VI  - 20
IP  - 10
DP  - 2023
TI  - Toxic Advanced Glycation End-Products-Dependent Alzheimer's Disease- Like 
      Alternation in the Microtubule System.
PG  - 677-681
LID - 10.2174/0115672050288723240213053342 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's Disease (AD). 
      However, the detailed mechanism underlying T2DM-related AD remains unknown. In 
      DM, many types of advanced glycation end-products (AGEs) are formed and 
      accumulated. In our previous study, we demonstrated that Glyceraldehyde 
      (GA)-derived Toxic Advanced Glycation End-products (Toxic AGEs, TAGE) strongly 
      showed cytotoxicity against neurons and induced similar alterations to those 
      observed in AD. Further, GA induced dysfunctional neurite outgrowth via TAGE-beta-- 
      tubulin aggregation, which resulted in the TAGE-dependent abnormal aggregation of 
      beta-tubulin and tau phosphorylation. Herein, we provide a perspective on the 
      possibility that T2DM increases the probability of AD onset and accelerates its 
      progression.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Ooi, Hayahide
AU  - Ooi H
AUID- ORCID: 0000-0001-6853-8964
AD  - Graduate School and Faculty of Pharmaceutical Sciences, Suzuka University of 
      Medical Science, 3500-3 Minamitamagaki, Suzuka 513-8670, Japan.
FAU - Koriyama, Yoshiki
AU  - Koriyama Y
AUID- ORCID: 0000-0001-8777-329X
AD  - Graduate School and Faculty of Pharmaceutical Sciences, Suzuka University of 
      Medical Science, 3500-3 Minamitamagaki, Suzuka 513-8670, Japan.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
RN  - 0 (Glycation End Products, Advanced)
RN  - 367-47-5 (Glyceraldehyde)
SB  - IM
MH  - Humans
MH  - *Alzheimer Disease/etiology
MH  - Glycation End Products, Advanced/toxicity
MH  - Maillard Reaction
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Microtubules
MH  - Glyceraldehyde
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Toxic advanced glycation end-products
OT  - diabetes mellitus
OT  - glyceraldehyde
OT  - tau phosphorylation.
OT  - beta-tubulin
EDAT- 2024/02/15 12:43
MHDA- 2024/04/03 06:44
CRDT- 2024/02/15 08:19
PHST- 2023/10/22 00:00 [received]
PHST- 2024/01/31 00:00 [revised]
PHST- 2024/01/31 00:00 [accepted]
PHST- 2024/04/03 06:44 [medline]
PHST- 2024/02/15 12:43 [pubmed]
PHST- 2024/02/15 08:19 [entrez]
AID - CAR-EPUB-138505 [pii]
AID - 10.2174/0115672050288723240213053342 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2023;20(10):677-681. doi: 
      10.2174/0115672050288723240213053342.