PMID- 38358185
OWN - NLM
STAT- MEDLINE
DCOM- 20240221
LR  - 20240221
IS  - 0974-5130 (Electronic)
IS  - 0377-4929 (Linking)
VI  - 67
IP  - 1
DP  - 2024 Jan-Mar
TI  - High expression of SHP2 predicts a promising prognosis in colorectal cancer.
PG  - 29-35
LID - 10.4103/ijpm.ijpm_894_22 [doi]
AB  - BACKGROUND: Src homology 2 domain-containing phosphatase 2 (SHP2) is 
      hyper-activated in some solid tumors. Previous findings suggest that the 
      expression of SHP2 in colorectal cancer (CRC) may be associated with prognosis. 
      However, validation with large sample data is lacking. Materials and Methods: 
      Tissue microarrays containing 860 CRCs and 197 mucosal tissues adjacent to the 
      tumors were constructed. Immunohistochemistry was used to evaluate the expression 
      of SHP2. Differences between SHP2 expression and clinicopathological parameters 
      were evaluated. Kaplan-Meier survival curves and log-rank tests were used to 
      analyze the relationships between SHP2 expression and the overall survival of 
      patients. A Cox proportional hazard regression model was used for univariate and 
      multivariate analyses of prognostic factors. RESULTS: SHP2 expression in CRCs 
      tissues was significantly higher than those in adjacent mucosal tissues (P < 
      0.001). SHP2 expression was related to tumor differentiation, depth of invasion, 
      distant metastasis, vascular tumor thrombus, lymph node metastasis, and TNM 
      classification (P < 0.05). The prognosis of the high-expression group of SHP2 was 
      significantly better than that of the low-expression group (P = 0.008). 
      Univariate analysis showed that the expression of SHP2 was a prognostic factor 
      for CRC (P = 0.008). Multivariate analysis demonstrated that SHP2 remained an 
      independent prognostic factor for CRC (P = 0.033). CONCLUSION: The expression of 
      SHP2 was significantly higher in CRC tissues than in adjacent normal tissues. 
      High expression of SHP2 was associated with a promising outcome, suggesting that 
      SHP2 may be a favorable prognostic indicator of CRC.
FAU - Liu, Xibo
AU  - Liu X
AD  - Department of Pathology, Shaoxing People's Hospital, Shaoxing, China.
FAU - Li, Mengyao
AU  - Li M
AD  - Department of Pathology, Shaoxing People's Hospital, Shaoxing, China.
FAU - Chen, Lirong
AU  - Chen L
AD  - Department of Pathology, China National Ministry of Education), The Second 
      Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 
      Zhejiang, China.
FAU - Wen, Fei
AU  - Wen F
AD  - Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China 
      National Ministry of Education), The Second Affiliated Hospital of Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang, China.
FAU - Zheng, Shu
AU  - Zheng S
AD  - Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China 
      National Ministry of Education), The Second Affiliated Hospital of Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang, China.
FAU - Ge, Weiting
AU  - Ge W
AD  - Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China 
      National Ministry of Education), The Second Affiliated Hospital of Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Pathol Microbiol
JT  - Indian journal of pathology & microbiology
JID - 7605904
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.1.3.48 (PTPN11 protein, human)
SB  - IM
MH  - Humans
MH  - *Biomarkers, Tumor/analysis
MH  - *Colorectal Neoplasms/pathology
MH  - Lymphatic Metastasis
MH  - Neoplasm Staging
MH  - Prognosis
OTO - NOTNLM
OT  - Colorectal neoplasms
OT  - SHP2
OT  - immunohistochemistry
OT  - prognosis
OT  - tissue microarrays
EDAT- 2024/02/15 12:42
MHDA- 2024/02/16 06:43
CRDT- 2024/02/15 08:47
PHST- 2024/02/16 06:43 [medline]
PHST- 2024/02/15 12:42 [pubmed]
PHST- 2024/02/15 08:47 [entrez]
AID - IndianJPatholMicrobiol_2024_67_1_29_381975 [pii]
AID - 10.4103/ijpm.ijpm_894_22 [doi]
PST - ppublish
SO  - Indian J Pathol Microbiol. 2024 Jan-Mar;67(1):29-35. doi: 
      10.4103/ijpm.ijpm_894_22.