PMID- 38360594
OWN - NLM
STAT- MEDLINE
DCOM- 20240219
LR  - 20240219
IS  - 1472-6831 (Electronic)
IS  - 1472-6831 (Linking)
VI  - 24
IP  - 1
DP  - 2024 Feb 15
TI  - Association of per- and polyfluoroalkyl substances (PFAS) with periodontitis: the 
      mediating role of sex hormones.
PG  - 243
LID - 10.1186/s12903-024-03863-0 [doi]
LID - 243
AB  - OBJECTIVES: To investigate the association between serum per- and polyfluoroalkyl 
      substances (PFAS) and periodontitis, and further explore the possible mediating 
      role of sex hormones in this association. METHODS: We extracted data from 
      National Health and Nutrition Examination Survey (NHANES) 2009-2014. Univariable 
      and multivariable logistic regression models were performed to investigate the 
      association between serum levels of seven PFASs and periodontitis. Bayesian 
      kernel machine regression (BKMR) was conducted to assess the joint effect of 
      PFASs in mixtures. Mediation analyses were used to explore the potential 
      mediating role of sex hormones. RESULTS: Participants with periodontitis had 
      higher concentrations of serum perfluorooctane sulfonate (PFOS) and 
      perfluorononanoic acid (PFNA) than those without periodontitis (both P < 0.05). 
      In fully adjusted models, high serum concentrations of PFOS and PFNA were 
      positively associated with periodontitis (tertile 3 vs. tertile 1: prevalence 
      ratio (PR) = 1.19 for PFOS, 95% CI: 1.01-1.39; PR = 1.17 for PFNA, 95% CI: 
      1.02-1.34). The results from the BKMR models consistently showed a positive 
      association between PFAS mixtures and periodontitis. Of note, testosterone and 
      the ratio of testosterone to estradiol significantly mediated the relationship 
      between high level of PFOS and periodontitis, accounting for 16.5% and 31.7% of 
      the total effect, respectively. Sensitivity analyses yielded similar results when 
      using periodontal clinical indices (mean loss of attachment, mean periodontal 
      probing depth, and the number of teeth) as dependent variables. CONCLUSIONS: 
      These findings provide evidence to support a positive association between certain 
      PFASs and periodontitis, which might be partially mediated by sex hormones.
CI  - (c) 2024. The Author(s).
FAU - Wu, Yuxuan
AU  - Wu Y
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, China.
FAU - Qiu, Yu
AU  - Qiu Y
AD  - Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of 
      Fujian Medical University, Fuzhou, 350122, China.
FAU - Wu, Yuying
AU  - Wu Y
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, China.
FAU - Li, Husheng
AU  - Li H
AD  - Department of Preventive Medicine, School of Public Health, Fujian Medical 
      University, Fuzhou, 350122, China.
FAU - Yang, Han
AU  - Yang H
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, China.
FAU - Deng, Qingrong
AU  - Deng Q
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, China.
FAU - He, Baochang
AU  - He B
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, China.
FAU - Yan, Fuhua
AU  - Yan F
AD  - Department of Periodontology, Nanjing Stomatological Hospital, Medical School of 
      Nanjing University, Nanjing, 210008, China.
FAU - Li, Yanfen
AU  - Li Y
AD  - Department of Periodontology, Nanjing Stomatological Hospital, Medical School of 
      Nanjing University, Nanjing, 210008, China. liyanfen2003@126.com.
FAU - Chen, Fa
AU  - Chen F
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou, 350122, China. chenfa@fjmu.edu.cn.
LA  - eng
GR  - H2019033/Jiangsu Health Commission Scientific Research Project/
GR  - 82301071/National Natural Science Foundation of China/
GR  - XRCZX2018001/High-level Talents research Start-up Project of Fujian Medical 
      University/
PT  - Journal Article
DEP - 20240215
PL  - England
TA  - BMC Oral Health
JT  - BMC oral health
JID - 101088684
RN  - 0 (Environmental Pollutants)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - 375-95-1 (perfluoro-n-nonanoic acid)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 3XMK78S47O (Testosterone)
RN  - 0 (Fluorocarbons)
RN  - 0 (Fatty Acids)
RN  - 0 (Alkanesulfonic Acids)
SB  - IM
MH  - Humans
MH  - *Environmental Pollutants
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - Gonadal Steroid Hormones
MH  - Testosterone
MH  - *Fluorocarbons
MH  - *Periodontitis
MH  - *Fatty Acids
MH  - *Alkanesulfonic Acids
PMC - PMC10870532
OTO - NOTNLM
OT  - NHANES
OT  - PFAS
OT  - PFNA
OT  - PFOS
OT  - Periodontitis
OT  - Population-based study
COIS- The authors declare no competing interests.
EDAT- 2024/02/16 00:42
MHDA- 2024/02/19 06:44
PMCR- 2024/02/15
CRDT- 2024/02/15 23:34
PHST- 2023/09/15 00:00 [received]
PHST- 2024/01/04 00:00 [accepted]
PHST- 2024/02/19 06:44 [medline]
PHST- 2024/02/16 00:42 [pubmed]
PHST- 2024/02/15 23:34 [entrez]
PHST- 2024/02/15 00:00 [pmc-release]
AID - 10.1186/s12903-024-03863-0 [pii]
AID - 3863 [pii]
AID - 10.1186/s12903-024-03863-0 [doi]
PST - epublish
SO  - BMC Oral Health. 2024 Feb 15;24(1):243. doi: 10.1186/s12903-024-03863-0.