PMID- 3836094
OWN - NLM
STAT- MEDLINE
DCOM- 19860820
LR  - 20190908
IS  - 8755-1039 (Print)
IS  - 1097-0339 (Linking)
VI  - 1
IP  - 4
DP  - 1985 Oct-Dec
TI  - Application of monoclonal antibody 44-3A6 in the cytodiagnosis and classification 
      of pulmonary carcinomas.
PG  - 300-7
AB  - Thirty-five pulmonary carcinomas were studied retrospectively with monoclonal 
      antibody (MCA) 44-3A6 raised against a human adenocarcinoma cell line. The 
      antibody was applied to cytologic smears of bronchial brushings originally 
      stained with the Papanicolau method, and to conventional tissue sections. Ten of 
      12 adenocarcinomas (ADC) immunostained strongly in sections and smears, as did 
      five of seven large-cell "undifferentiated" carcinomas (LCUC). Eight 
      neuroendocrine carcinomas (NEC) and eight squamous-cell carcinomas (SCC) were 
      negative, except for rare weakly positive foci. We conclude that MCA 44-3A6 can 
      be effectively applied on cytologic smears, and that it could be valuable in the 
      precise classification of pulmonary carcinomas. The immunoreactivity of the ADC 
      and SCC was predictable. Positive immunostaining in some LCUC confirms that these 
      constitute a heterogeneus tumor class that includes cases that are phenotypically 
      ADC despite the absence of obvious glands. Occasional immunostaining in NEC 
      suggests focal exocrine differentiation as previously noted by electron 
      microscopy.
FAU - Banner, B F
AU  - Banner BF
FAU - Gould, V E
AU  - Gould VE
FAU - Radosevich, J A
AU  - Radosevich JA
FAU - Ma, Y
AU  - Ma Y
FAU - Lee, I
AU  - Lee I
FAU - Rosen, S T
AU  - Rosen ST
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - 0 (Antibodies, Monoclonal)
SB  - IM
MH  - Adenocarcinoma/diagnosis
MH  - Adult
MH  - Aged
MH  - *Antibodies, Monoclonal
MH  - Carcinoma/classification/*diagnosis
MH  - Carcinoma, Squamous Cell/diagnosis
MH  - Endocrine System Diseases/diagnosis
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/classification/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Nervous System Neoplasms/diagnosis
EDAT- 1985/10/01 00:00
MHDA- 1985/10/01 00:01
CRDT- 1985/10/01 00:00
PHST- 1985/10/01 00:00 [pubmed]
PHST- 1985/10/01 00:01 [medline]
PHST- 1985/10/01 00:00 [entrez]
AID - 10.1002/dc.2840010408 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 1985 Oct-Dec;1(4):300-7. doi: 10.1002/dc.2840010408.