PMID- 38361124
OWN - NLM
STAT- MEDLINE
DCOM- 20240219
LR  - 20240219
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Print)
IS  - 0301-4851 (Linking)
VI  - 51
IP  - 1
DP  - 2024 Feb 16
TI  - Pectolinarigenin regulates the tumor-associated proteins in AGS-xenograft BALB/c 
      nude mice.
PG  - 305
LID - 10.1007/s11033-023-09046-4 [doi]
LID - 305
AB  - BACKGROUND: Pectolinarigenin (PEC) is a flavone extracted from Cirsium, and 
      because it has anti-inflammatory properties, anti-cancer research is also being 
      conducted. The objective of this work was to find out if PEC is involved in tumor 
      control and which pathways it regulates in vivo and in vitro. METHODS: AGS cell 
      lines were xenografted into BALB/c nude mice to create tumors, and PEC was 
      administered intraperitoneally to see if it was involved in tumor control. Once 
      animal testing was completed, tumor proteins were isolated and identified using 
      LC-MS analysis, and gene ontology of the found proteins was performed. RESULTS: 
      Body weight and hematological measurements on the xenograft mice model 
      demonstrated that PEC was not harmful to non-cancerous cells. We found 582 
      proteins in tumor tissue linked to biological reactions such as carcinogenesis 
      and cell death signaling. PEC regulated 6 out of 582 proteins in vivo and in 
      vitro in the same way. CONCLUSION: Our findings suggested that PEC therapy may 
      inhibit tumor development in gastric cancer (GC), and proteomic research gives 
      fundamental information about proteins that may have great promise as new 
      therapeutic targets in GC.
CI  - (c) 2024. The Author(s).
FAU - Lee, Ho Jeong
AU  - Lee HJ
AD  - Gyeongnam Bio-Health Research Support Center, Gyeongnam Branch Institute, Korea 
      Institute of Toxicology (KIT), 17 Jeigok-gil, Jinju, 52834, Republic of Korea.
FAU - Kwon, Young Sang
AU  - Kwon YS
AD  - Environmental Safety Assessment Center, Gyeongnam Branch Institute, Korea 
      Institute of Toxicology (KIT), 17 Jeigok-gil, Jinju, 52834, Republic of Korea.
FAU - Lee, Ju Hong
AU  - Lee JH
AD  - Gyeongnam Bio-Health Research Support Center, Gyeongnam Branch Institute, Korea 
      Institute of Toxicology (KIT), 17 Jeigok-gil, Jinju, 52834, Republic of Korea.
FAU - Moon, Yeon Gyu
AU  - Moon YG
AD  - Gyeongnam Bio-Health Research Support Center, Gyeongnam Branch Institute, Korea 
      Institute of Toxicology (KIT), 17 Jeigok-gil, Jinju, 52834, Republic of Korea.
FAU - Choi, Jungil
AU  - Choi J
AD  - Gyeongnam Bio-Health Research Support Center, Gyeongnam Branch Institute, Korea 
      Institute of Toxicology (KIT), 17 Jeigok-gil, Jinju, 52834, Republic of Korea.
FAU - Hyun, Moonjung
AU  - Hyun M
AD  - Gyeongnam Bio-Health Research Support Center, Gyeongnam Branch Institute, Korea 
      Institute of Toxicology (KIT), 17 Jeigok-gil, Jinju, 52834, Republic of Korea.
FAU - Tak, Tae Kil
AU  - Tak TK
AD  - Gyeongnam Bio-Health Research Support Center, Gyeongnam Branch Institute, Korea 
      Institute of Toxicology (KIT), 17 Jeigok-gil, Jinju, 52834, Republic of Korea.
FAU - Kim, Je-Hein
AU  - Kim JH
AD  - Gyeongnam Bio-Health Research Support Center, Gyeongnam Branch Institute, Korea 
      Institute of Toxicology (KIT), 17 Jeigok-gil, Jinju, 52834, Republic of Korea.
FAU - Heo, Jeong Doo
AU  - Heo JD
AUID- ORCID: 0000-0001-9646-195X
AD  - Gyeongnam Bio-Health Research Support Center, Gyeongnam Branch Institute, Korea 
      Institute of Toxicology (KIT), 17 Jeigok-gil, Jinju, 52834, Republic of Korea. 
      jdher@kitox.re.kr.
LA  - eng
GR  - 2020R1F1A1074115/National Research Foundation of Korea/
GR  - NRF-2022R1F1A1069365/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20240216
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (pectolinarigenin)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - 0 (Chromones)
SB  - IM
MH  - Humans
MH  - Animals
MH  - Mice
MH  - Mice, Nude
MH  - *Apoptosis
MH  - Heterografts
MH  - Proteomics
MH  - Cell Line, Tumor
MH  - *Stomach Neoplasms/genetics
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Cell Proliferation
MH  - *Chromones
PMC - PMC10869406
OTO - NOTNLM
OT  - AGS-xenograft
OT  - PI3K/AKT/mTOR
OT  - Pectolinarigenin
OT  - Proteomics
OT  - Tumor suppress
COIS- The authors have no relevant financial or non-financial interests to disclose.
EDAT- 2024/02/16 06:42
MHDA- 2024/02/19 06:43
PMCR- 2024/02/16
CRDT- 2024/02/16 00:05
PHST- 2023/03/07 00:00 [received]
PHST- 2023/10/30 00:00 [accepted]
PHST- 2024/02/19 06:43 [medline]
PHST- 2024/02/16 06:42 [pubmed]
PHST- 2024/02/16 00:05 [entrez]
PHST- 2024/02/16 00:00 [pmc-release]
AID - 10.1007/s11033-023-09046-4 [pii]
AID - 9046 [pii]
AID - 10.1007/s11033-023-09046-4 [doi]
PST - epublish
SO  - Mol Biol Rep. 2024 Feb 16;51(1):305. doi: 10.1007/s11033-023-09046-4.