PMID- 38362860
OWN - NLM
STAT- Publisher
LR  - 20240223
IS  - 1464-5165 (Electronic)
IS  - 0963-8288 (Linking)
DP  - 2024 Feb 16
TI  - Clinical application of transcutaneous auricular vagus nerve stimulation: a 
      scoping review.
PG  - 1-31
LID - 10.1080/09638288.2024.2313123 [doi]
AB  - PURPOSE: Transcutaneous auricular vagus nerve stimulation (taVNS) is an emerging 
      non-invasive neuromodulation therapy. This study aimed to explore the therapeutic 
      use of taVNS, optimal stimulation parameters, effective sham protocols, and 
      safety. METHODS: A scoping review was conducted. Five databases and grey 
      literature were searched. The data extracted included stimulation parameters, 
      adverse events (AEs), and therapeutic effects on clinical outcomes. RESULTS: 109 
      studies were included. taVNS was used across 21 different clinical populations, 
      most commonly in psychiatric, cardiac, and neurological disorders. Overall, 2,214 
      adults received active taVNS and 1,017 received sham taVNS. Reporting of 
      stimulation parameters was limited and inconsistent. taVNS appeared to have a 
      favourable therapeutic effect across a wide range of clinical populations with 
      varied parameters. Three sham protocols were reported but their effectiveness was 
      documented in only two of the 54 sham-controlled studies. Most reported adverse 
      events were localised to stimulation site. CONCLUSION: There is growing evidence 
      for taVNS therapeutic effect. taVNS appears safe and tolerable. Sham protocols 
      need evaluation. Standardised and comprehensive reporting of both stimulation 
      parameters and adverse events is required. Two different questionnaires have been 
      proposed to evaluate adverse events and the effectiveness of sham methods in 
      blinding participants.
FAU - Gerges, Ashraf N H
AU  - Gerges ANH
AUID- ORCID: 0000-0001-9211-6585
AD  - Innovation, Implementation and Clinical Translation (IIMPACT) in Health, Allied 
      Health and Human Performance, University of South Australia, Adelaide, Australia.
FAU - Williams, Ellen E R
AU  - Williams EER
AUID- ORCID: 0000-0002-9922-5255
AD  - School of Biomedicine, Faculty of Health and Medical Sciences, University of 
      Adelaide, Adelaide, Australia.
AD  - Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health 
      and Medical Research Institute (SAHMRI), Adelaide, Australia.
FAU - Hillier, Susan
AU  - Hillier S
AUID- ORCID: 0000-0002-6071-6137
AD  - Innovation, Implementation and Clinical Translation (IIMPACT) in Health, Allied 
      Health and Human Performance, University of South Australia, Adelaide, Australia.
FAU - Uy, Jeric
AU  - Uy J
AUID- ORCID: 0000-0002-1122-5593
AD  - Innovation, Implementation and Clinical Translation (IIMPACT) in Health, Allied 
      Health and Human Performance, University of South Australia, Adelaide, Australia.
FAU - Hamilton, Taya
AU  - Hamilton T
AD  - Perron Institute for Neurological and Translational Science, Perth, Australia.
AD  - Fourier Intelligence International Pte Ltd., Global Headquarters, Singapore, 
      Singapore.
FAU - Chamberlain, Saran
AU  - Chamberlain S
AD  - Innovation, Implementation and Clinical Translation (IIMPACT) in Health, Allied 
      Health and Human Performance, University of South Australia, Adelaide, Australia.
FAU - Hordacre, Brenton
AU  - Hordacre B
AUID- ORCID: 0000-0002-7129-6684
AD  - Innovation, Implementation and Clinical Translation (IIMPACT) in Health, Allied 
      Health and Human Performance, University of South Australia, Adelaide, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20240216
PL  - England
TA  - Disabil Rehabil
JT  - Disability and rehabilitation
JID - 9207179
SB  - IM
OAB - Transcutaneous auricular vagus nerve stimulation (taVNS) showed therapeutic 
      effect across a wide range of clinical populations including depression, 
      epilepsy, and strokeThere is a preliminary indication that daily/weekly dose and 
      overall duration of treatment are important to show therapeutic effectivenessWhen 
      using taVNS as an intervention, the questionnaires proposed in this review should 
      be used to evaluate blinding effectiveness and adverse events.
OABL- eng
OTO - NOTNLM
OT  - VNS
OT  - neuromodulation
OT  - rehabilitation
OT  - transauricular stimulation
EDAT- 2024/02/16 12:45
MHDA- 2024/02/16 12:45
CRDT- 2024/02/16 07:57
PHST- 2024/02/16 12:45 [pubmed]
PHST- 2024/02/16 12:45 [medline]
PHST- 2024/02/16 07:57 [entrez]
AID - 10.1080/09638288.2024.2313123 [doi]
PST - aheadofprint
SO  - Disabil Rehabil. 2024 Feb 16:1-31. doi: 10.1080/09638288.2024.2313123.