PMID- 38363435
OWN - NLM
STAT- MEDLINE
DCOM- 20240320
LR  - 20240322
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 40
IP  - 3
DP  - 2024 Mar
TI  - Morphometrics predicts the differential regurgitant fraction in bilateral 
      pulmonary arteries of patients with repaired tetralogy of fallot.
PG  - 655-664
LID - 10.1007/s10554-023-03035-1 [doi]
AB  - In patients with repaired tetralogy of Fallot (rTOF), the regurgitant fraction 
      (RF) in left pulmonary artery (LPA) and right pulmonary artery (RPA) is usually 
      unequal. The morphometrics may play a crucial role in this RF discrepancy. 
      Cardiovascular MR of 79 rTOF patients and 20 healthy controls were 
      retrospectively enrolled. Forty-four from the 79 patients were matched in age, 
      sex and body surface area to the 20 controls and were investigated for: (1) 
      phase-contrast flow of main pulmonary artery (MPA), LPA, and RPA; (2) vascular 
      angles: the angles between the thoracic anterior-posterior line (TAPL) with MPA 
      (theta(M-AP)), MPA with RPA (theta(M-R)), and MPA with LPA (theta(M-L)); (3) cardiac angle, 
      the angle between TAPL and the interventricular septum; (4) area ratio of 
      bilateral lung and hemithorax regions. Compared with the 20 controls, the 44 rTOF 
      patients exhibited wider theta(M-AP), sharper theta(M-L) angle, and a smaller 
      theta(M-L)/theta(M-R) ratio. In the 79 rTOF patients, LPA showed lower forward, backward, 
      and net flow, and greater RF as compared with RPA. Multivariate analysis showed 
      that the RF of LPA was negatively associated with the theta(M-L)/theta(M-R) ratio and the 
      age at surgery (R(2) = 0.255). Conversely, the RF of RPA was negatively 
      associated with the left lung/left hemithorax area ratio and cross-sectional area 
      (CSA) of LPA, and positively associated with CSA of RPA and MPA (R(2) = 0.366). 
      In rTOF patients, the RF of LPA is more severe than that of RPA, which may be 
      related to the vascular morphometrics. Different morphometric parameters 
      are independently associated with the RF of LPA or RPA, which may offer potential 
      insights for surgical strategies.
CI  - (c) 2024. The Author(s).
FAU - Teng, Hui-Chung
AU  - Teng HC
AD  - Department of Radiology, Kaohsiung Veterans General Hospital, No. 386, Dazhong 
      1st Rd., Zuoying District, Kaohsiung, 813414, Taiwan.
AD  - Department of Nursing, Mei Ho University, Pingtung, Taiwan.
AD  - School of Medicine, College of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
FAU - Chen, Yi-Chun
AU  - Chen YC
AD  - Department of Radiology, Kaohsiung Veterans General Hospital, No. 386, Dazhong 
      1st Rd., Zuoying District, Kaohsiung, 813414, Taiwan.
AD  - Department of Nursing, Mei Ho University, Pingtung, Taiwan.
AD  - School of Medicine, College of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
FAU - Chen, Yung-Lin
AU  - Chen YL
AD  - Department of Radiology, Kaohsiung Veterans General Hospital, No. 386, Dazhong 
      1st Rd., Zuoying District, Kaohsiung, 813414, Taiwan.
AD  - Department of Nursing, Mei Ho University, Pingtung, Taiwan.
AD  - School of Medicine, College of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
FAU - Weng, Ken-Pen
AU  - Weng KP
AD  - School of Medicine, College of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Congenital Structural Heart Disease Center, Department of Pediatrics, Kaohsiung 
      Veterans General Hospital, Kaohsiung, Taiwan.
FAU - Pan, Jun-Yen
AU  - Pan JY
AD  - Division of Cardiovascular Surgery, Department of Surgery, Kaohsiung Veterans 
      General Hospital, Kaohsiung, Taiwan.
FAU - Chang, Ming-Hua
AU  - Chang MH
AD  - Department of Radiology, Kaohsiung Veterans General Hospital, No. 386, Dazhong 
      1st Rd., Zuoying District, Kaohsiung, 813414, Taiwan.
FAU - Cheng, Hsiu-Wen
AU  - Cheng HW
AD  - Department of Radiology, Kaohsiung Veterans General Hospital, No. 386, Dazhong 
      1st Rd., Zuoying District, Kaohsiung, 813414, Taiwan.
FAU - Wu, Ming-Ting
AU  - Wu MT
AD  - Department of Radiology, Kaohsiung Veterans General Hospital, No. 386, Dazhong 
      1st Rd., Zuoying District, Kaohsiung, 813414, Taiwan. wu.mingting@gmail.com.
AD  - School of Medicine, College of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan. wu.mingting@gmail.com.
AD  - Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, 
      Taiwan. wu.mingting@gmail.com.
LA  - eng
GR  - KSVGH112-022/Veterans General Hospitals and University System of Taiwan Joint 
      Research Program/
GR  - VGHUST108-G3-3-2, VGHUST109-V3-3-3/Veterans General Hospitals and University 
      System of Taiwan Joint Research Program/
PT  - Journal Article
DEP - 20240216
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - Humans
MH  - Pulmonary Artery/diagnostic imaging/surgery
MH  - *Tetralogy of Fallot/diagnostic imaging/surgery
MH  - Retrospective Studies
MH  - *Pulmonary Valve Insufficiency/diagnostic imaging/etiology/surgery
MH  - Predictive Value of Tests
MH  - *Ventricular Septum
PMC - PMC10950999
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance
OT  - Differential regurgitant fraction
OT  - Pulmonary artery angle
OT  - Pulmonary regurgitation
OT  - Tetralogy of fallot
COIS- The authors have no relevant financial or non-financial interests to disclose.
EDAT- 2024/02/16 12:43
MHDA- 2024/03/20 06:45
PMCR- 2024/02/16
CRDT- 2024/02/16 11:10
PHST- 2023/10/28 00:00 [received]
PHST- 2023/12/13 00:00 [accepted]
PHST- 2024/03/20 06:45 [medline]
PHST- 2024/02/16 12:43 [pubmed]
PHST- 2024/02/16 11:10 [entrez]
PHST- 2024/02/16 00:00 [pmc-release]
AID - 10.1007/s10554-023-03035-1 [pii]
AID - 3035 [pii]
AID - 10.1007/s10554-023-03035-1 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2024 Mar;40(3):655-664. doi: 
      10.1007/s10554-023-03035-1. Epub 2024 Feb 16.