PMID- 38364758
OWN - NLM
STAT- MEDLINE
DCOM- 20240226
LR  - 20240226
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 272
DP  - 2024 Mar 1
TI  - Association between urinary polycyclic aromatic hydrocarbons and unexplained 
      recurrent spontaneous abortion from a case-control study.
PG  - 116093
LID - S0147-6513(24)00168-4 [pii]
LID - 10.1016/j.ecoenv.2024.116093 [doi]
AB  - Polycyclic aromatic hydrocarbons (PAHs) have been reported to be associated with 
      adverse pregnancy outcomes. However, there is limited knowledge regarding the 
      effects of single or mixed PAHs exposure on unexplained recurrent spontaneous 
      abortion (URSA). This study aimed to investigate the association between 
      monohydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and URSA in a 
      case-control study. The results showed that 1-NAP, 2-NAP, 9-FLU, and 1-PYR were 
      detected in 100% of the subjects among measured all sixteen OH-PAHs. Compared 
      with those in the lowest quartiles, participants in the highest quartiles of 
      3-BAA were associated with a higher risk of URSA (OR (95%CI) = 3.56(1.28-9.85)). 
      With each one-unit increase of ln-transformed 3-BAA, the odds of URSA increased 
      by 41% (OR (95%CI) = 1.41(1.05-1.89)). Other OH-PAHs showed negative or 
      non-significant associations with URSA. Weighted quantile sum (WQS) regression, 
      Bayesian kernel machine regression (BKMR), and quantile-based g-computation 
      (qgcomp) analyses consistently identified 3-BAA as the major contributor to the 
      mixture effect of OH-PAHs on URSA. Our findings suggest that exposure to 3-BAA 
      may be a potential risk factor for URSA. However, further prospective studies are 
      needed to validate our findings in the future.
CI  - Copyright (c) 2024 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Lv, Chunxian
AU  - Lv C
AD  - China CDC Key Laboratory of Environment and Population Health, National Institute 
      of Environmental Health, Chinese Center for Disease Control and Prevention, 
      Beijing 100021, China.
FAU - Li, Dandan
AU  - Li D
AD  - Fengtai District Center for Disease Control and Prevention, Beijing 
      100071, China.
FAU - Zhang, Zheng
AU  - Zhang Z
AD  - China CDC Key Laboratory of Environment and Population Health, National Institute 
      of Environmental Health, Chinese Center for Disease Control and Prevention, 
      Beijing 100021, China; Center for Global Health, School of Public Health, Nanjing 
      Medical University, Nanjing 211166, China.
FAU - Han, Yingying
AU  - Han Y
AD  - Fengtai District Center for Disease Control and Prevention, Beijing 
      100071, China.
FAU - Li, Yawei
AU  - Li Y
AD  - China CDC Key Laboratory of Environment and Population Health, National Institute 
      of Environmental Health, Chinese Center for Disease Control and Prevention, 
      Beijing 100021, China.
FAU - Song, Haocan
AU  - Song H
AD  - China CDC Key Laboratory of Environment and Population Health, National Institute 
      of Environmental Health, Chinese Center for Disease Control and Prevention, 
      Beijing 100021, China.
FAU - Cheng, Qianxi
AU  - Cheng Q
AD  - China CDC Key Laboratory of Environment and Population Health, National Institute 
      of Environmental Health, Chinese Center for Disease Control and Prevention, 
      Beijing 100021, China.
FAU - Yang, Siyu
AU  - Yang S
AD  - Institute of Public Health, Henan Provincial Center for Disease Control and 
      Prevention, Zhengzhou, Henan 450016, China.
FAU - Lu, Yifu
AU  - Lu Y
AD  - China CDC Key Laboratory of Environment and Population Health, National Institute 
      of Environmental Health, Chinese Center for Disease Control and Prevention, 
      Beijing 100021, China; Center for Global Health, School of Public Health, Nanjing 
      Medical University, Nanjing 211166, China. Electronic address: 
      luyifu@nieh.chinacdc.cn.
FAU - Zhao, Feng
AU  - Zhao F
AD  - China CDC Key Laboratory of Environment and Population Health, National Institute 
      of Environmental Health, Chinese Center for Disease Control and Prevention, 
      Beijing 100021, China. Electronic address: zhaofeng@nieh.chinacdc.cn.
LA  - eng
PT  - Journal Article
DEP - 20240215
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *Polycyclic Aromatic Hydrocarbons/toxicity
MH  - *Abortion, Spontaneous/chemically induced/epidemiology
MH  - Case-Control Studies
MH  - Bayes Theorem
MH  - Risk Factors
MH  - Biomarkers
OTO - NOTNLM
OT  - Case-control study
OT  - Mixed exposure analysis
OT  - Polycyclic aromatic hydrocarbons
OT  - Unexplained recurrent spontaneous abortion
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/02/17 10:43
MHDA- 2024/02/26 06:43
CRDT- 2024/02/16 18:17
PHST- 2023/11/22 00:00 [received]
PHST- 2024/02/05 00:00 [revised]
PHST- 2024/02/07 00:00 [accepted]
PHST- 2024/02/26 06:43 [medline]
PHST- 2024/02/17 10:43 [pubmed]
PHST- 2024/02/16 18:17 [entrez]
AID - S0147-6513(24)00168-4 [pii]
AID - 10.1016/j.ecoenv.2024.116093 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2024 Mar 1;272:116093. doi: 10.1016/j.ecoenv.2024.116093. 
      Epub 2024 Feb 15.