PMID- 3836690
OWN - NLM
STAT- MEDLINE
DCOM- 19860917
LR  - 20131121
IS  - 0883-1386 (Print)
IS  - 0883-1386 (Linking)
VI  - 6
IP  - 6
DP  - 1985-1986
TI  - Ethanol-stress interaction on dopamine metabolism in the medial prefrontal 
      cortex.
PG  - 449-54
AB  - The effect of foot-shock and ethanol (2 g/kg per os) and the combination of the 
      two on dopamine (DA) metabolism in the medial prefrontal cortex (MPFC) was 
      studied in rats. Electric foot-shock stress (20 min stimulation) decreased DA 
      concentration by 30% and increased dihydroxyphenylacetic acid (DOPAC) 
      concentration by 65%. Ethanol (2 g/kg orally) decreased DA concentration by 20%, 
      but, unlike foot-shock, failed to modify DOPAC levels. Neither treatments 
      modified homovanillic acid (HVA) levels. The combination of ethanol (30 min 
      before shock) and foot-shock produced about a 50% depletion of DA content and 30% 
      increase in HVA, but no change in DOPAC levels. It is suggested that both ethanol 
      and foot-shock activate DA release in the MPFC, but ethanol decreases DA 
      retrieval by nerve terminals and, therefore, prevents intraneuronal deamination 
      of the amine.
FAU - Fadda, F
AU  - Fadda F
FAU - Mosca, E
AU  - Mosca E
FAU - Meloni, R
AU  - Meloni R
FAU - Gessa, G L
AU  - Gessa GL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Alcohol Drug Res
JT  - Alcohol and drug research
JID - 8601074
RN  - 0 (Receptors, Dopamine)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 3K9958V90M (Ethanol)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Dopamine/*metabolism
MH  - Electroshock
MH  - Ethanol/*pharmacology
MH  - Frontal Lobe/*drug effects/metabolism
MH  - Homovanillic Acid/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Dopamine/*drug effects/metabolism
MH  - Stress, Psychological/*complications
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
PST - ppublish
SO  - Alcohol Drug Res. 1985-1986;6(6):449-54.