PMID- 38367144
OWN - NLM
STAT- Publisher
LR  - 20240217
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
DP  - 2024 Feb 17
TI  - Association between phase angle and diabetic peripheral neuropathy in Type 2 
      diabetes patients.
LID - 10.1007/s12020-024-03689-4 [doi]
AB  - BACKGROUND: Diabetic peripheral neuropathy (DPN), the very prevalent 
      microvascular complication of type 2 diabetes mellitus (T2DM), severely threatens 
      the quality of life of diabetic patients. Thus, prevention of DPN is extremely 
      important for public health, and the identification of potential biomarkers may 
      help with early prevention. Our work determined the association between phase 
      angles (PhAs) and the risk of DPN in T2DM patients. MATERIALS AND METHODS: This 
      cross-sectional study recruited 697 T2DM patients from the Third Affiliated 
      Hospital of Soochow University. All patients were divided into the non-diabetic 
      peripheral neuropathy group and diabetic peripheral neuropathy group, and the DPN 
      group was further divided into low, medium, and high diabetic foot ulcer risk 
      groups according to vibration perception threshold results. Using univariate and 
      multivariate logistic regression analyses continuously, the relationship between 
      PhAs (arms, legs, trunk, and whole body) and the risk of DPN were evaluated. 
      Further analysis was conducted on different subgroups of the study population. 
      RESULTS: After adjusting for the potential covariates, multivariate logistic 
      regression analyses indicated that PhAs of the arms, legs, and whole body 
      correlated inversely with the risk of DPN. However, the PhA of the trunk had no 
      significant correlation with DPN. According to the stratified subgroup analysis, 
      the negative association between PhA of the whole body and the risk of DPN 
      remained significant in the sex and BMI group except for participants with 
      BMI >/= 28 kg/m(2). CONCLUSIONS: For the first time, PhAs were acknowledged to be 
      independently associated with DPN. Further exploration is needed to explain the 
      findings.
CI  - (c) 2024. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Zhang, Junli
AU  - Zhang J
AD  - Department of Endocrinology and Metabolism, The Third Affiliated Hospital of 
      Soochow University, Changzhou, 213003, China.
FAU - Xu, Zhenghui
AU  - Xu Z
AD  - Department of Endocrinology and Metabolism, The Third Affiliated Hospital of 
      Soochow University, Changzhou, 213003, China.
FAU - Fu, Yu
AU  - Fu Y
AD  - Department of Clinical Nutrition, The Third Affiliated Hospital of Soochow 
      University, Changzhou, 213003, China.
FAU - Chen, Lu
AU  - Chen L
AD  - Department of Endocrinology and Metabolism, The Third Affiliated Hospital of 
      Soochow University, Changzhou, 213003, China. chenluforever@163.com.
AD  - Department of Clinical Nutrition, The Third Affiliated Hospital of Soochow 
      University, Changzhou, 213003, China. chenluforever@163.com.
LA  - eng
PT  - Journal Article
DEP - 20240217
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
SB  - IM
OTO - NOTNLM
OT  - Diabetic peripheral neuropathy
OT  - Phase angle
OT  - Type 2 diabetes mellitus
EDAT- 2024/02/17 21:42
MHDA- 2024/02/17 21:42
CRDT- 2024/02/17 11:08
PHST- 2023/08/23 00:00 [received]
PHST- 2024/01/06 00:00 [accepted]
PHST- 2024/02/17 21:42 [medline]
PHST- 2024/02/17 21:42 [pubmed]
PHST- 2024/02/17 11:08 [entrez]
AID - 10.1007/s12020-024-03689-4 [pii]
AID - 10.1007/s12020-024-03689-4 [doi]
PST - aheadofprint
SO  - Endocrine. 2024 Feb 17. doi: 10.1007/s12020-024-03689-4.