PMID- 38368646
OWN - NLM
STAT- MEDLINE
DCOM- 20240325
LR  - 20240325
IS  - 1876-035X (Electronic)
IS  - 1876-0341 (Linking)
VI  - 17
IP  - 4
DP  - 2024 Apr
TI  - Genetic variants associated with dengue hemorrhagic fever. A systematic review 
      and meta-analysis.
PG  - 579-587
LID - S1876-0341(24)00027-3 [pii]
LID - 10.1016/j.jiph.2024.02.001 [doi]
AB  - Dengue hemorrhagic fever (DHF) is a severe condition resulting from the dengue 
      virus, with four serotypes known as DEN-1, DEN-2, DEN-3, and DEN-4. Genetic 
      variations play a crucial role in influencing susceptibility to DHF. Therefore, 
      this investigation conducted a meta-analysis to uncover genetic changes that 
      might have remained undetected in individual studies due to small sample sizes or 
      methodological differences. Among 2212 initially identified studies, 23 were 
      deemed suitable for analysis based on PRISMA guidelines. Toll-like receptors 
      (TLR) and CD209 showed significant association with DHF (odds ratios: TLR=0.56, 
      CD209 =0.55), indicating protective effects. However, tumor necrosis factor (TNF) 
      and human leukocyte antigen (HLA) did not exhibit a statistically significant 
      relationship with DHF. This study emphasizes the relevance of TLR and CD209 in 
      DHF susceptibility and resistance across diverse geographical locations.
CI  - Copyright (c) 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Kanan, Mohammed
AU  - Kanan M
AD  - Department of Clinical Pharmacy, King Fahad Medical City, Riyadh 12211, Saudi 
      Arabia.
FAU - Naffaa, Mohammed
AU  - Naffaa M
AD  - Department of Forensic Toxicology, Poison Center, Arar, Northern Borders Region 
      73241, Saudi Arabia.
FAU - Alanazi, Ahmed
AU  - Alanazi A
AD  - Poison Control and Forensic Chemistry Center, Arar, Northern Borders Region 
      73551, Saudi Arabia.
FAU - Nasser, Faiz
AU  - Nasser F
AD  - Department of Forensic Toxicology, Poison Center, Arar, Northern Borders Region 
      75861, Saudi Arabia.
FAU - Alsaiari, Ahad Amer
AU  - Alsaiari AA
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
FAU - Almehmadi, Mazen
AU  - Almehmadi M
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
FAU - Assiry, Ali
AU  - Assiry A
AD  - Department of Medical Supply, Mohayil Hospital, Health Affairs of Aseer, Abha 
      63711, Saudi Arabia.
FAU - Muzafar, Hisham
AU  - Muzafar H
AD  - Department of Pharmacy, Jazan University Hospital, Jazan University, Jazan 82723, 
      Saudi Arabia.
FAU - Katam, Hejab
AU  - Katam H
AD  - Department of Radiology, Extended Care Hospital, Arar, Northern Borders Region 
      73551, Saudi Arabia.
FAU - Arar, Abdullah
AU  - Arar A
AD  - Public Health Department, Northern Border Regional Lab & Blood Bank, Arar, 
      Northern Borders Region 73241, Saudi Arabia.
FAU - Asdaq, Syed Mohammed Basheeruddin
AU  - Asdaq SMB
AD  - Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, 
      Dariyah, 13713 Riyadh, Saudi Arabia.
FAU - Abida
AU  - Abida
AD  - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border 
      University, Rafha 91911, Saudi Arabia.
FAU - Imran, Mohd
AU  - Imran M
AD  - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border 
      University, Rafha 91911, Saudi Arabia. Electronic address: imran.pchem@gmail.com.
FAU - Dzinamarira, Tafadzwa
AU  - Dzinamarira T
AD  - School of Health Systems and Public Health, University of Pretoria, Pretoria 
      0002, South Africa; ICAP, Columbia University, P.O. Box 28, Harare, Zimbabwe. 
      Electronic address: u19395419@up.ac.za.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20240203
PL  - England
TA  - J Infect Public Health
JT  - Journal of infection and public health
JID - 101487384
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - *Severe Dengue/genetics
MH  - *Dengue Virus/genetics
MH  - Tumor Necrosis Factor-alpha/genetics
MH  - Serogroup
MH  - Case-Control Studies
MH  - *Dengue/genetics
OTO - NOTNLM
OT  - Dengue virus
OT  - Human leukocyte antigen
OT  - Meta-analysis
OT  - Odd ratio
OT  - TNF toll-like receptors
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2024/02/18 18:42
MHDA- 2024/03/25 06:44
CRDT- 2024/02/18 18:00
PHST- 2023/05/05 00:00 [received]
PHST- 2024/01/25 00:00 [revised]
PHST- 2024/02/01 00:00 [accepted]
PHST- 2024/03/25 06:44 [medline]
PHST- 2024/02/18 18:42 [pubmed]
PHST- 2024/02/18 18:00 [entrez]
AID - S1876-0341(24)00027-3 [pii]
AID - 10.1016/j.jiph.2024.02.001 [doi]
PST - ppublish
SO  - J Infect Public Health. 2024 Apr;17(4):579-587. doi: 10.1016/j.jiph.2024.02.001. 
      Epub 2024 Feb 3.